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Dental Panoramic Radiography in Age Estimation for Dental Care using Dark-Net 19
Jihyeong Ko,Yu-Rin Kim,Han-Jeong Hwang,Won-Du Chang,Man Seok Han,Seoul-Hee Nam,Young-Jin Jung 한국자기학회 2022 Journal of Magnetics Vol.27 No.4
A rapidly increasing human lifespan has led to population aging with growing demands for healthcare, including dental healthcare services. The oral cavity plays a crucial role in mastication and speech. Furthermore, artificial intelligence (AI) has extensively developed, and automated diagnostic technology continues to evolve. Therefore, it is necessary to integrate objective AI, automatic diagnosis, and dental care to reduce errors resulting from subjective diagnosis. This study used 15,000 dental panoramic X-ray images to train an AI algorithm and estimate dental age, using Darknet-19 for the AI model. The accuracy was about 84 % and 96 %, respectively, when the dental estimate acceptable range was ± 5 and ± 10 years. Based on this model, patients could evaluate their oral condition and improve their quality of life using appropriate treatment and prevention methods.
Sinae Kim,Jong Ho Lee,Siyoung Lee,Saerok Shim,Tam T. Nguyen,Jihyeong Hwang,Heijun Kim,Yeo-Ok Choi,Jaewoo Hong,Suyoung Bae,Hyun Jhung Jhun,Hokee Yum,이영민,Edward D. Chan,Liping Yu,Tania Azam,Yong-Dae Kim 대한면역학회 2020 Immune Network Vol.20 No.5
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is a positive-sense single-stranded RNA (+ssRNA) that causes coronavirus disease 2019 (COVID-19). The viral genome encodes twelve genes for viral replication and infection. The third open reading frame is the spike (S) gene that encodes for the spike glycoprotein interacting with specific cell surface receptor – angiotensin converting enzyme 2 (ACE2) – on the host cell membrane. Most recent studies identified a single point mutation in S gene. A single point mutation in S gene leading to an amino acid substitution at codon 614 from an aspartic acid 614 into glycine (D614G) resulted in greater infectivity compared to the wild type SARS-CoV2. We were interested in investigating the mutation region of S gene of SARS-CoV2 from Korean COVID-19 patients. New mutation sites were found in the critical receptor binding domain (RBD) of S gene, which is adjacent to the aforementioned D614G mutation residue. This specific sequence data demonstrated the active progression of SARS-CoV2 by mutations in the RBD of S gene. The sequence information of new mutations is critical to the development of recombinant SARS-CoV2 spike antigens, which may be required to improve and advance the strategy against a wide range of possible SARS-CoV2 mutations.
Park, Youngmin,Xu, Zheng-Yi,Kim, Soo Youn,Lee, Jihyeong,Choi, Bongsoo,Lee, Juhun,Kim, Hyeran,Sim, Hee-Jung,Hwang, Inhwan Americ 2016 The Plant cell Vol.28 No.10
<P>The phytohormone abscisic acid (ABA) plays crucial roles in various physiological processes, including responses to abiotic stresses, in plants. Recently, multiple ABA transporters were identified. The loss-of-function and gain-of-function mutants of these transporters show altered ABA sensitivity and stomata regulation, highlighting the importance of ABA transporters in ABA-mediated processes. However, how the activity of these transporters is regulated remains elusive. Here, we show that spatial regulation of ATP BINDING CASETTE G25 (ABCG25), an ABA exporter, is an important mechanism controlling its activity. ABCG25, as a soluble green fluorescent protein (sGFP) fusion, was subject to posttranslational regulation via clathrin-dependent and adaptor protein complex-2-dependent endocytosis followed by trafficking to the vacuole. The levels of sGFP: ABCG25 at the plasma membrane (PM) were regulated by abiotic stresses and exogenously applied ABA; PM-localized sGFP: ABCG25 decreased under abiotic stress conditions via activation of endocytosis in an ABA-independent manner, but increased upon application of exogenous ABA via activation of recycling from early endosomes in an ABA-dependent manner. Based on these findings, we propose that the spatial regulation of ABCG25 is an important component of the mechanism by which plants fine-tune cellular ABA levels according to cellular and environmental conditions.</P>