Use of dihydropyridine calcium channel blockers in the management of hypertension in Eastern Asians: A scientific statement from the Asian Pacific Heart Association

Wang, Ji-Guang,Kario, Kazuomi,Lau, Titus,Wei, Yong Quek,Park, Chang Gyu,Kim, Cheol Ho,Huang, Jun,Zhang, Weizhong,Li, Yong,Yan, Peter,Hu, Dayi Springer Science and Business Media LLC 2011 Hypertension research Vol.34 No.4

<P>Dihydropyridine calcium channel blockers (CCBs) are widely prescribed for the management of hypertension in Eastern Asians. In this study, the Asian Pacific Heart Association's Writing Committee reviewed randomized controlled trials that were conducted in the Eastern Asian region and compared a CCB with an antihypertensive drug of another class. These trials studied ambulatory blood pressure, measures of target organ damage and cardiovascular events as outcomes. Eleven trials studied ambulatory blood pressure in hypertensive patients and demonstrated that the 24-h blood pressure reduction with CCBs was greater than with other classes of antihypertensive drugs, with a weighted mean difference of 5?mm?Hg systolic and 3?mm?Hg diastolic. Twelve trials that studied various measurements of target organ damage in hypertensive patients produced inconsistent results when comparing CCBs and other classes of antihypertensive drugs. Four trials that studied the hard outcomes had limited power, but confirmed the findings of previous placebo-controlled trials in the region and actively controlled trials in Europe and North America; they suggested that CCBs provided superior protection against stroke and that some agents, such as amlodipine, also provided similar protection against myocardial infarction. In conclusion, CCBs should be recommended as a preferred drug for the management of hypertension in the Eastern Asian region to improve blood pressure control and to confront the aggravating epidemic of stroke and coronary heart disease.</P>

MiR-34b/c rs4938723 Polymorphism Significantly Decreases the Risk of Digestive Tract Cancer: Meta-analysis

Ji, Tian-Xing,Zhi, Cheng,Guo, Xue-Guang,Zhou, Qiang,Wang, Guo-Qiang,Chen, Bo,Ma, Fei-Fei Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Background: Previous studies investigating the association between miR-34b/c rs4938723 polymorphism and cancer risk showed inconclusive. Here, we performed meta-analysis to investigate the association between miR- 34b/c rs4938723 polymorphism and digestive cancer risk. Materials and Methods: Literature database including PubMed, OVID, Chinese National Knowledge Infrastructure (CNKI) were searched for publications concerning the association between the miR-34b/c rs4938723 polymorphism and digestive cancer risk. Results: A total of 6 studies consisting of 3246 cases and 3568 controls were included in this meta-analysis. The combined analysis suggested the miR-34b/c rs4938723 polymorphism significantly reduced digestive cancer risk under allelic model, homogeneous co-dominant model and recessive model (C vs T: OR=0.88, 95%CI=0.82-0.95, p-value=0.001; CC vs TT: OR =0.67, 95%CI=0.57-0.80, p-value=0.000; CC vs TT/TC: OR=0.68, 95%CI=0.58-0.80, p-value=0.000). Q-test and I2 test revealed no significant heterogeneity in all genotype comparisons. The Begger's funnel plot and Egger's test did not show significant publication bias. Conclusions: The current evidence supports the conclusion that the miR-34b/c rs4938723 polymorphism decreases an individual's susceptibility to digestive cancers.

Effect of synthesis conditions on the particle size and morphology of YAG powder

Jie-Guang Song,Fang Wang,Ming-Han Xu,Yin-Yan Ju,Yang-Liang Li,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.2

Yttrium aluminum garnet (YAG) is currently a widely applied structural and functional material. To prepare highperformance YAG ceramics we prepared pure YAG powder, after calcining the precursor at 1100 ºC, by co-precipitation with ammonia as the precipitant and aluminum nitrate as well as yttrium nitrate as raw materials. The preparation conditions for the YAG precursor were a pH of 9, a titration rate of 10 ml/ minute and a reaction time of 60 minutes. The mean paricle size of the YAG powder was 11ìm. The mean particle size for the YAG powder increased with an increase in the pH and at a higher pH the YAG particles were more irregular in shape. The mean particle size and particle size distribution range of the YAG powder increased with an increase in the titration rate. For the YAG powder with a higher mean particle size, the particle size distribution range was wider but the size of most YAG particles was still small and the YAG particles were nearly spherical.

Effect of the sintering technology on the properties of fired brick from quartz sands

Jie-Guang Song,Fang Wang,Xiao-Bo Bai,Da-Ming Du,Yin-Yan Ju,Ming-Han Xu,Gang-Chang Ji 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.4

River sands as low grade natural raw materials are used to prepare the fired brick to replace clay fired bricks, which aims to save land resources and use low grade natural resources to realize high cost performance. In this paper, the effect of sintering technology of bricks on their performance is discussed. The compressive strength of fired bricks is first increased and then decreased with an increase in the sintering temperature, the compressive strength of bricks prepared by the isostatic compaction shaping is higher than that of bricks prepared by the plastic shaping under the same conditions. The compressive strength of bricks reaches 28 MPa when sintered at 1150 oC by using a 20MPa isostatic compaction shaping method. The compressive strength of bricks is first increased and then decreased by prolonging the holding time, the compressive strength of bricks reaches 28.9MPa when sintered at 1150 oC for 2 h.

The effect of the oxidation conditions on the surface microdomains of ZrB2-YAG ultra-high temperature ceramics

Jie-Guang Song,Min-Han Xu,Da-Ming Du,Fang Wang,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.4

Zirconium diboride is widely applied because of some excellent properties. The effect of the oxidation temperature on the surface microdomain of ZrB2-YAG multi-phase ceramics was studied, it helps to improve the performance of ultra-hightemperature ceramics. The results show the oxidation layer thickness is increased with an increase in the oxidation temperature, the oxidation layer thickness is decreased by increasing the density of multi-phase ceramics at the same oxidation temperature. The ceramic surface shows the (m)ZrO2, YAG, B2O3 and ZrB2 phases below the the oxidation temperature at 1300 ο C, but the ceramic surface do not show the ZrB2 phase above the oxidation temperature at 1300 ο C that is to say, the ZrB2 phase of the ceramic suface is entirely oxidized. The oxidation layer thickness is increased with an increase in the oxidation time, however, the ratio of increasing thickness is less and less. The oxidation layer shows a loose structure during the initial stage of the oxidation, which lacks a barriers for the diffusion of the oxygen.

Effect of raw materials on the properties of ZrB2-YAG-Al2O3 multi-phase ceramics

Jie-Guang Song,Fang Wang,Da-Ming Du,Yin-Yan Ju,Shi-Bin Li,Gang-Chang Ji,Lian-Meng Zhang 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.2

ZrB2 belongs to a class of ceramics defined ultra-high-temperature ceramics with extremely high melting temperatures, but ZrB2 ceramics is difficultly sintered and easily oxidized. To make ZrB2 ceramics possess the high relative density and the better oxidation resistance. The effects of raw materials on the properties of ZrB2 composite were investigated. YAG and Al2O3 help for the densification of ZrB2 ceramics. Fracture toughness of sintered ceramics with coated powder is higher than that of sintered ceramics with mixed powder. The mechanical property of ZrB2-YAG-Al2O3 materials is higher than that of ZrB2-YAG materials. Oxidation layer thickness of sintered ceramics with coated powder is thinner than that of sintered ceramics with mixed powder. These results show the sintered ZrB2 based multi-phase ceramics with coated microstructure help to increase the mechanical properties and oxidation resistance. The oxidation resistance of ZrB2-YAG-Al2O3 ceramics is better than that of ZrB2-YAG materials.

The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramcis

Jie-Guang Song,Fang Wang,Ming-Han Xu,Shi-Bin Li,Gang-Chang Ji 한양대학교 세라믹연구소 2012 Journal of Ceramic Processing Research Vol.13 No.3

ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have a better oxidation resistance, high-density ZrB2-YAG-Al2O3 ceramics were prepared. The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramics is investigated at different high temperature ranges. The results show that the overall tendency of the weight gain of ZrB2-YAG ceramics and ZrB2 ceramics are similar, but the weight gain of ZrB2-YAG ceramics is less than that of ZrB2 ceramics. The weight gain tendency of three types of ceramics are similar below 1000, the weight gain of ZrB2-YAG and ZrB2-YAG-Al2O3 ceramics have a mild tendency between 1000 and 1300, the weight gain tendency of ZrB2-YAG ceramics and ZrB2 ceramics are similar at 1300, however, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics became mild at 1300 due to the Al18B4O33 coating on the ceramic surface. The weight gain rapidly increased for 1h, then the weight gain tendency became mild after 1 h. The weight gain tendency of ZrB2-YAG-Al2O3 ceramics is similar by contrast with ZrB2-YAG ceramics and ZrB2 ceramics for 1 h, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics is extremely mild at a higher oxidation temperature after 1 h. ZrB2 and YAG are widely applied because of some excellent properties, but ZrB2 is easily oxidized in high-temperature air. To make ZrB2 ceramics have a better oxidation resistance, high-density ZrB2-YAG-Al2O3 ceramics were prepared. The effect of a reinforcement phase on the oxidation mechanism of ZrB2-YAG-Al2O3 ceramics is investigated at different high temperature ranges. The results show that the overall tendency of the weight gain of ZrB2-YAG ceramics and ZrB2 ceramics are similar, but the weight gain of ZrB2-YAG ceramics is less than that of ZrB2 ceramics. The weight gain tendency of three types of ceramics are similar below 1000, the weight gain of ZrB2-YAG and ZrB2-YAG-Al2O3 ceramics have a mild tendency between 1000 and 1300, the weight gain tendency of ZrB2-YAG ceramics and ZrB2 ceramics are similar at 1300, however, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics became mild at 1300 due to the Al18B4O33 coating on the ceramic surface. The weight gain rapidly increased for 1h, then the weight gain tendency became mild after 1 h. The weight gain tendency of ZrB2-YAG-Al2O3 ceramics is similar by contrast with ZrB2-YAG ceramics and ZrB2 ceramics for 1 h, the weight gain tendency of ZrB2-YAG-Al2O3 ceramics is extremely mild at a higher oxidation temperature after 1 h.

The Effects of ALA-PDT on Leukemia Cells and Hepatoma Cells

Chen, Ji-Yao,Ren, Qing-Guang,Wu, Su-Min,Wang, Pei-Nan Korean Society of Photoscience 2002 Journal of Photosciences Vol.9 No.2

S-aminolevulinic acid (ALA) is a new kind drug used in photodynamic therapy. ALA-PDT have successfully used in superficial malignancies and some skin diseases. Here the effects of ALA-PDT were studied on leukemia cells and hepatoma cells to explore the application on different kind cancers. It was found from the fluorescence emission spectra, that after ALA incubation the sensitizer - protoporphyrin IX (PpIX) was endogenously produced in both leukemia and hepatoma cells. The fluorescence images showed that the PpIX distribute in cytoplasm. However the efficiency of ALA photodynamic inactivation to two cell lines was different. The leukemia cells were more sensitive for ALA-PDT than hepatoma cells, revealing that the ALA-PDT effect is cell line dependent. However by using ALA-Hexyl ester (He-ALA) instead of ALA, the cell photo-inactivation was improved. The PDT efficiency of He-ALA was 10 times high than that of ALA, showing He-ALA is a very promising drug in ALA-PDT.

Three New 11,20-Epoxy-ent-kauranoids from Isodon rubescens

Xu Liu,Ji Zhou Wu,Rui Zhan,Wei Guang Wang,Xue Du,Yan Li,Peng Zhang,Jian Xin Pu,Han Dong Sun 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

Three rare and new 11,20-epoxy-ent-kaurane diterpenoids, named jianshirubesins D-F (1-3), along with one known analogue (4), were isolated from the aerial parts of Isodon rubescens. Their structures were established by analysis of spectroscopic data. Found in the MTT assay to evaluate the cytotoxicity of compounds 1, 2, and 4, only 1 could selectively inhibit certain cell lines from proliferating. In addition, a simple structure-activity relationship discussion might suggest a new bioactive moiety, different from the α,β-unsaturated ketone group.

High Repetition Wavelength-locked 878.6 nm LD Dual-end-pumped Nd:YVO₄ 1064 nm Laser

Li, Yue,Yu, Yong-Ji,Wang, Yu-Heng,Liu, Hang,Liu, He-Yan,Jin, Guang-Yong Optical Society of Korea 2018 Current Optics and Photonics Vol.2 No.6

A $Nd:YVO_4$ laser dual-end-pumped by a wavelength-locked 878.6 nm laser diode is presented. At the repetition rate of 500 KHz, the absorbed pump power of 58 W, an output power of 26.1 W at 1064 nm is obtained, corresponding to an optical-optical efficiency of 45%. The pulse width is 44.2 ns. Meanwhile, the effects of traditional 808 nm pumping and 878.6 nm dual-end-pumping on the output laser beam quality and pulse width are compared and analyzed in an experiment.