조현병 환자의 내재화된 낙인과 관련된 요인

정유란(Yuran Jeong),유태영(Taeyoung Yoo),이주연(Ju-Yeon Lee),김선영(Seon-Young Kim),김재민(Jae-Min Kim),윤진상(Jin-Sang Yoon),김성완(Sung-Wan Kim) 대한생물치료정신의학회 2017 생물치료정신의학 Vol.23 No.2

Objectives:Patients with schizophrenia have high levels of self-perceived stigma, which frequently hinders successful treatment. The aim of this study was to investigate the factors related with internalized stigma in patients with schizophrenia. Methods:A total of 123 patients with schizophrenia according to Diagnostic and Statistical Manual of Mental disorders 5th edition(DSM-5) criteria were enrolled. Sociodemographic and clinical variables including previous suicidal attempt history were assessed. Self-perceived stigma was assessed using Korean version of Internalized Stigma of Mental Illness Scale(K-ISMI). Clinical characteristics and psychopathology were measured using the Positive and Negative Syndrome Scale(PANSS), Beck Depression Inventory(BDI), Beck Hopelessness Scale-7(BHS-7), Rosenberg Self Esteem Scale(R-SES), and EuroQol-5 dimensions visual analog scale(EQ5D-VAS). Results:The K-ISMI total scores had significantly negative correlations with scores on the R-SES and EQ-VAS, and significantly positive correlations with scores on the BDI, BHS-7, and PANSS negative and general psychopathology subscales after controlling age and duration of illness. Patients with previous suicidal attempt history showed significantly higher scores on the K-ISMI scores. Conclusion:Internalized stigma of patients with schizophrenia was associated with low self-esteem, poor quality of life, history of suicidal attempt and higher level of depression, hopelessness, and negative symptoms. Clinicians should carefully evaluate and manage self-perceived stigma of patients with schizophrenia.

A nanostructured cell-free photosynthetic biocomposite via molecularly controlled layer-by-layer assembly

Shon, Yuran,Kim, Hyun,Hwang, Hong Seop,Bae, Eun Sil,Eom, Taesik,Park, Eui Jung,Ahn, Wha-Seung,Wie, Jeong Jae,Shim, Bong Sup Elsevier 2017 Sensors and actuators. B Chemical Vol.244 No.-

<P><B>Abstract</B></P> <P>Thylakoids, on which complete sets of photosynthetic membrane proteins are contained, behave as soft nanoparticles of a few tens nm sizes. Thus, we separated the thylakoid extracts from spinach chloroplasts and densely organized them in a film with either insulating polyethyleneimine (PEI) or conducting polyaniline (PANI) by molecularly controlled layer-by-layer (LBL) assembly. The resulting nanostructured composite films demonstrated photoelectrochemical activities with thylakoids whose stabilities were significantly improved on the charge balanced LBL multilayers compared to one on a randomly deposited film or in solution. The thylakoid LBL films continuously generated photochemical electrons for longer than 130h with the 2,6-dichlorophenolindophenol (DCPIP) mediated photosynthetic energy conversion cycle while photoactivities of thylakoid moiety slowly decreased in the open circuit potential measurements throughout which the photosynthetic redox cycles were incomplete. As the photofunctional groups of the thylakoid films originated from a biotic system and the photofuctional thylakoids were exceptionally well preserved on the charge-balanced artificial structures, the developed thylakoid LBL film have shown inherent biocompatibility upon PC12 neural cell attachment and differentiation tests, which are essential qualities for emerging human-friendly electronic applications such as disposable electronics, artificial retina, and implantable neural interfacing meditronics as well as cell-free photosynthetic production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Thylakoid complexes, extracted from spinach chloroplasts, were densely organized in a film with insulating polyethyleneimine (PEI) or conducting polyaniline (PANI) by layer-by-layer (LBL) assembly. </LI> <LI> The thylakoid LBL films continuously generated photochemical electrons for longer than 130h. </LI> <LI> The thylakoid LBL film has shown inherent biocompatibility upon PC12 neural cell attachment and differentiation tests. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

A Study on High Performance Converter Topology for Hydrogen Gas Generation Electrolysis System

Taewon Kang(강태원),Yuran Go(고유란),Yongsug Suh(서용석),Junik Jeong(정준익),Dohawn Rho(노도환) 전력전자학회 2010 전력전자학술대회 논문집 Vol.2010 No.7

This paper investigates a high performance converter topology for hydrogen gas generation electrolysis system. The proposed converter topology consists of full-bridge inverter, medium frequency transformer, and diode rectifier. Hydrogen gas generation electrolysis process considered in the paper is analyzed and characterized by its equivalent circuit. The electrolysis cell is modeled as effective resistance, capacitance, inductance, and internal emf voltage source. The proposed converter topology provides enhanced efficiency of hydrogen gas generation process under the operating condition of dc output voltage with high frequency ripple on it. The high performance operation of proposed converter is confirmed through the simulation with the electrolysis cell considered in the equivalent circuit model.

Soft electronics on asymmetrical porous conducting membranes by molecular layer-by-layer assembly

Kim, Hyun,Eom, Tae Sik,Cho, Whirang,Woo, Kyungbae,Shon, Yuran,Wie, Jeong Jae,Shim, Bong Sup Elsevier 2018 Sensors and actuators. B Chemical Vol.254 No.-

<P><B>Abstract</B></P> <P>Achieving biological softness and flexibility has been a critical challenge for bio-electronic materials in areas of implantable bionic interfaces and wearable devices. Unlike inherently rigid electronic materials, bioengineered interfaces or scaffolds require stretchable softness as well as functional porosity for selective ionic transports. Toward this goal of providing electrically conducting biomaterials, we report ultrathin single-walled carbon nanotube (SWNT) layer coating on biodegradable polycaprolactone (PCL) membranes via layer-by-layer (LBL) assembly technique. The resulting membranes have unique, hierarchically structured 3D network of conductive paths around asymmetric nano-/micro-pores, providing softness as well as stretchable, anisotropic electrical conductivity. The strain sensors embedded on the membrane also demonstrate bending directional sensitivity as well as piezoresistivity with tunable Gauge Factor (GF) in the ranges of 5–13 with stretchability of up to 100%. Furthermore, these composite membranes are biocompatible as evident by neuronal cell attachment tests with <I>in vitro</I> PC12 cell lines. As follows, this newly developed implantable multifunctional membrane has considerable potential for applications in bioengineered devices such as mechano-sensitive artificial interfaces and skins.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We report ultrathin single-walled carbon nanotube (SWNT) layer coating on biodegradable polycaprolactone (PCL) membranes via layer-by-layer (LBL) assembly technique. </LI> <LI> The membranes have hierarchically structured 3D network of conductive paths around asymmetric nano-/micro-pores, providing softness as well as stretchable, anisotropic electrical conductivity. </LI> <LI> The strain sensors embedded on the membrane demonstrate bending directional sensitivity as well as piezoresistivity with tunable Gauge Factor (GF) in the ranges of 5–13 with stretchability of up to 100%. </LI> <LI> The composite membranes are also biocompatible as evident by neuronal cell attachment tests with <I>in vitro</I> PC12 cell lines. </LI> <LI> This newly developed implantable multifunctional membrane has considerable potential for applications in bioengineered devices such as mechano-sensitive artificial interfaces and skins. </LI> </UL> </P>

Affective State and Corresponding Psychophysiological Findings of Healthcare Workers in Coronavirus Disease of 2019 Screening Centers

Choi Soo-Jong,Yoon Bo-Hyun,Yun Hyunju,Kim Kyungmin,Jeong Yuran,Kang Hangoeunbi,Song Jye-Heon,Sea Young-Hwa,Park Suhee 대한우울조울병학회 2023 우울조울병 Vol.21 No.3

Background: This study explores the impact of the coronavirus disease of 2019 (COVID-19) pandemic on the mental health of healthcare workers in COVID-19 Screening Centers, focusing on anxiety and depression and their psychophysiological findings. Methods: The research involved 610 healthcare workers in Gwangju and Jeollanam-do, South Korea, from March to November 2022. Self-reported questionnaires and psychophysiological measurements using Neuronicle FX2 (Omnifitmindcare®) were employed. Results: Among 610 participants (107 males, 503 females), the high-risk anxiety group (60 individuals, 15 males and 45 females) and high-risk depression group (79 individuals, 19 males and 60 females) showed elevated physical symptoms compared to the normal group. The high-risk anxiety group exhibited lower mean r-r intervals, higher heart rate per minute, greater stress index, and lower vigor index. For electroencephalogram (EEG) measures, the high-risk anxiety group showed higher brain activity, lower alpha asymmetry, reduced total theta power, and higher beta/theta (left, right, total) ratios. The high-risk depression group showed significantly lower alpha asymmetry in EEG. Conclusion: This study explored anxiety and depression prevalence among healthcare workers in the Gwangju-Jeonnam region at COVID-19 testing centers. Correlations between mental states and physical symptoms were observed, emphasizing the potential of EEG and heart rate variability as physiological indicators in psychiatric evaluations during the pandemic.

Development of Lifestyle Scale for Psychiatric Patients with Metabolic Syndrome

Choi Young-Wook,Yoon Bo-Hyun,Kang Hangoeunbi,Kim Kyungmin,Jeong Yuran,Yun Hyunju,Song Jye-Heon,Sea Young-Hwa,Park Suhee,Kang Se-Won 대한우울조울병학회 2023 우울조울병 Vol.21 No.3

Background: This study, examines the applicability of the Lifestyle Evaluation Tool for Patients with Metabolic Syndrome (LET-PMS) questionnaire, originally developed for general population, on psychiatric patients with metabolic syndrome. Methods: The study included 320 patients diagnosed with schizophrenia spectrum disorder (N=190), bipolar spectrum disorder (N=65), and depressive disorder (N=65). They were provided assignments using 36 items from the LET-PMS questionnaire and various established scales. The evaluation encompassed psychometric properties of reliability, exploratory factor, and confirmatory factor analysis. Results: We refined the LET-PMS questionnaire by eliminating six items through a reliability test. The resultant questionnaire exhibited six factors. The overall Cronbach’s alpha value was 0.896, with factor-specific reliability coefficients ranging from 0.730 to 0.859. Based on confirmatory factor analysis of the adapted LET-PMS, the root mean square error of approximation was 0.069 (0.05-1.1). Goodness-of-fit and comparative fit indexes were 0.815 and 0.821, respectively. All 30 items met the criteria for suitable configuration. Conclusion: The LET-PMS questionnaire demonstrated robust internal consistency and sound structural validity, making it suitable for psychiatric patients with metabolic syndrome.

Relationship between Depression and Stress-Coping Strategies in Public Enterprise Workers Whose Workplaces Were Relocated to a New Environment

Joo Minah,Yoon Bo-Hyun,Song Jye-Heon,Kim Kyungmin,Kang Hangoeunbi,Park Suhee,Jeong Yuran,Yun Hyunju,Lee Jongtae,Choi Koosang 대한우울조울병학회 2021 우울조울병 Vol.19 No.3

Background: In this study, the relationship between depression and stress-coping strategies among public enterprise workers whose workplaces were relocated to a newly-built innovation city was investigated. Methods: This study included a total of 922 public enterprise workers living in Naju Innovation City. Along with their sociodemographic data, each subject was assessed concerning depression, occupational stress, and stress-coping strategies using the Center for Epidemiologic Studies Depression Scale(CES-D), Korean Occupational Stress Scale (KOSS), and stress-coping scale (SCS), respectively. Logistic regression was performed to investigate the impact of the relevant factors on depressive symptoms. Results: The overall prevalence of depressive symptoms was 14%. Some sociodemographic variables, the total scores of the KOSS, and four subscales of the SCS revealed significant differences between the depressed and normal groups. Multivariate regression analysis revealed that the KOSS (odds ratio [OR], 1.17; p<0.001) and SCS, such as problem-solving-focused (OR, 0.75; p<0.001), emotion-focused (OR, 1.15; p<0.05), and wishful-thinking-focused (OR, 1.10; p<0.05), were significantly associated with depression. Conclusion: The results indicated that depressive symptoms were highly prevalent among workers whose workplaces were relocated. In addition, these symptoms were found to be related with occupational stress and stress-coping strategies. Our findings also suggest that promoting healthy stress-coping strategies and reducing occupational stress may help in preventing the occurrence of depression and managing depressed workers.

Psychiatric Comorbidities of Hazardous Alcohol Drinking in College Students

Choi Bowon,Yoon Bo-Hyun,Park Suhee,Kim Kyungmin,Kang Hangoeunbi,Sea Young-Hwa,Song Jye-Heon,Bae Jungeun,Jeong Yuran 대한우울조울병학회 2021 우울조울병 Vol.19 No.3

Background: Alcohol drinking among college students is socially permissible in Korea. However, this population’s tendency to consume alcohol excessively results in many alcohol-related problems, including psychiatric problems. This study aimed to identify the sociodemographic characteristics and psychiatric comorbidities associated with hazardous alcohol drinking among college students. Methods: In total, 2,571 college students participated in the study. Data were collected using the Korean version of the Alcohol Use Disorders Identification Test (AUDIT-K), the Mood Disorder Questionnaire, the Center for Epidemiologic Studies Depression Scale, a modified Korean version of the 16-item Prodromal Questionnaire, the Adult Attention- Deficit/Hyperactivity Disorder Self-Report Scale-Version 1.1, and a stress-coping scale. Logistic regression analysis was performed on variables significantly correlated with hazardous alcohol drinking. Results: In total, 633 students were grouped into the hazardous alcohol drinking group (AUDIT-K, ≥12). The associated variables were age (odds ratio [OR], 0.95; p<0.05), smoking (OR, 4.00; p<0.001), bipolar disorder (OR, 2.45; p<0.05), depressive disorder (OR, 1.35; p<0.05), attention-deficit/hyperactivity disorder (ADHD; OR, 1.44; p<0.05), and problem-focused stress coping (OR, 0.97; p<0.05). Conclusion: In this study, hazardous alcohol drinking was associated with smoking, mood disorders, and ADHD. We suggest that alcohol use among college students be carefully monitored and managed in terms of its psychiatric comorbidities.

A 4-Year Observation of the Incidence of Depression and Suicide Among Older Adults from the Onset of the COVID-19

Lee Seoung-Kyun,Yoon Bo-Hyun,Kim Kyungmin,Jung Ha-Ran,Kang Hangoeunbi,Jeong Yuran,Yun Hyunju,Song Jye-Heon,Sea Young-Hwa,Park Suhee 대한우울조울병학회 2023 우울조울병 Vol.21 No.3

Background: This study aimed to examine the influence of the coronavirus disease pandemic 2019 (COVID-19) by comparing the incidences of depression, suicidal ideation, and suicidal attempts before and after the outbreak of the pandemic among community-dwelling older adults. Methods: In total, 9,784 older adults were recruited from 22 counties in Jeollanam-do between 2019 and 2022. Self-reported questionnaires, including sociodemographic factors, suicidal ideation, suicidal attempt, and Geriatric Depression Scale-Short Form Korean version, were used. Results: The proportion of the depression high-risk group tended to increase since the COVID-19 outbreak, increasing to 16.3%, 23.1%, and 25.7% in 2019, 2020, and 2021, respectively; however, decreased to 21.8% in 2022. The incidence of suicidal ideation showed a similar pattern. The incidence of suicidal attempts showed a different pattern, rising to 1.3% and 2.6% in 2019 and 2020, respectively and then falling to 1.1% and 0.8% in 2021 and 2022, respectively. Conclusion: This study examined community-dwelling older adults and their mental states during the COVID-19 pandemic, and found that the risk of depression among older adults increased 1.708-fold in 2020, 1.877-fold in 2021, and 1.599-fold in 2022 compared to that in 2019, the year before the pandemic. Similarly, the risk of suicidal ideation increased by 1.582-fold in 2020, 1.913-fold in 2021, and 1.623-fold in 2022 compared with 2019 data. As the pandemic extended, mental health states improved; however, not to prepandemic levels. Suggesting that older people need continued support to alleviate the negative effects of the COVID-19 pandemic.