http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jeong, Jee-Heon,Yook, Simmyung,Byun, Youngro The Polymer Society of Korea 2016 Macromolecular Research Vol.24 No.12
Improvements in preventing pancreatic islet rejection are needed for successful treatment of type 1 diabetes. Our objective was to develop an optimized protocol combining modification of islets with polyethyleneglycol (PEG) chains and administration of tacrolimus (FK506, Prograf), an immunosuppressive drug for preventing rejection following transplantation. Freshly isolated islets were incubated with different concentrations (0.25, 1.00, 10.00, and 25.00%) of FITC-labeled mPEG-SCM (MW. 20 KDa) for various incubation times. 1% mPEG-SCM incubated with islets for 1 h is optimized surface coverage condition without cell toxicity. In addition, in order to optimize the concentration of tacrolimus (FK506, Prograf), different concentrations (0.1, 0.5 or 2.0 mg/kg) were injected into the diabetic mice following transplantation of PEGylated islets. The PEGylated islet survival time in mice injected daily with 0.1 mg/kg and 0.5 mg/kg of tacrolimus was significantly better than in the group without tacrolimus injection. The graft survival time in mice injected daily with 2.00 mg/kg of exhibited no prolonged survival time. Finally, immunohistochemical staining of left kidney containing PEGylated islets (injected with 0.1 mg/kg of tacrolimus) demonstrated strong staining for insulin, glucagon, and somatostatin but very weak CD20 staining was observed in the islet transplanted area. In conclusion, 1% mPEG-SCM incubated with islets for 1 h was the optimal condition for PEGylation without affecting the cell viability. A dose of tacrolimus between 0.1-0.5 mg/kg was highly effective for inhibiting immune cell activation. These results are promising for their application in developing a novel immunosuppressive protocol for successful pancreatic islet transplantation in the treatment of type 1 diabetes.
Jee-Young Pyo,Jeong Sun Park,Min Jee Kim,Heon Cheon Jeong,Sung-Soo Kim,Yutaka Banno,Seung Hyun Lee,Min Woo Park,Iksoo Kim 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
Bombyx mandarina (Lepidoptera: Bombycidae), the presumed ancestor of B. mori, has long been a subject of study to illustrate the geographic relationships in connection with origin of B. mori. We report 97 mitochondrial genome (mitogenome) sequences of B. mandarina collected from Korea and Japan. Phylogenetic and population genetic analyses showed that all individuals of B. mandarina collected in Korean localities formed a strong group together with all individuals originated from northern China (mainly north of the Qinling-Huaihe line) and some of southern China. This group was placed as the sister group to B. mori strians suggesting that this group had been served as an immediate progenitor for B. mori.
( Jee Heon Jeong ) 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
It is important to chase the function of islet after transplantation. Thus, we examined the correlation between grafted islets function and molecular imaging intensity using Cy5.5 labeled islet. The ability of Cy5.5- PEG-NHS to chemically bind on the surface of islets was determined by confocal laser scanning microscope. Then, fluorescence intensity of different number of Cy5.5 labeled islets was determined using optical imaging system. We have found out the intensity of fluorescence increased with increasing the total number of islet in each well. In addition, different number of Cy5.5-labeled islet has been transplanted into the athymic mice for in vivo imaging. The intensity emitted from Cy5.5-labeled islets augmented proportionally with increased number of transplanted islets. To understand the correlation between the function of grafted islet and the fluorescence intensity emitted optical imaging system, Cy5.5-labeled islets have been transplanted into F344 rats. The results revealed that there was a correlation between the fluorescence intensity and the nonfasting blood glucose (NBG) levels of islets received rats. Strong fluorescence intensity corresponded to low NBG whereas low signal was associated to high NBG. In conclusion, the fluorescence intensity emitted from Cy5.5- labeled islets can be used as a marker of cells viability and functionality after transplantation.
Jeong, Jee-Heon,Woo, Yoon-Joo,Lee, Mihyun,Haque, Muhammad R.,Ahn, Cheol-Hee,Lee, Haeshin,Byun, Youngro THE KOREAN SOCIETY OF INDUSTRIAL AND ENGINEERING 2018 JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY -S Vol.57 No.-
<P><B>Abstract</B></P> <P>Porcine islets are an alternative cell source for cell replacement therapy in diabetes. However, porcine islets are very fragile, and isolated islets are easily damaged during culture. Therefore, the purpose of this study was to incorporate a tissue-adhesive chitosan derivative on the surface of porcine islets to prevent the dissociation of porcine islet clusters into single cells. Chitosan-catechol was evenly covered on the surface of islets without any toxicity. In addition, the tissue-adhesive chitosan catechol was effective in preventing cell dissociation. Therefore, tissue adhesive chitosan-catechol conjugation onto the porcine islet surface is a promising technique to stabilize islets after isolation.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jee-Young Pyo,Jeong Sun Park,Min Jee Kim,Heon Cheon Jeong,Sung-Soo Kim,Yutaka Banno,Iksoo Kim 한국응용곤충학회 2024 한국응용곤충학회 학술대회논문집 Vol.2024 No.04
Bombyx mandarina (Lepidoptera: Bombycidae), the presumed ancestor of the domesticated silkworm B. mori, has long been a subject of study to illustrate the geographic relationships in connection with origin of B. mori. We sequenced 100 mitochondrial genomes of B. mandarina collected from South Korea and Japan and these were combined with public data. Phylogenetic and population genetic analyses showed that all individuals collected in South Korea, except one individual from Inje, formed a strong group together with northern China and some individuals of southern China. This group was placed as the sister group to B. mori strains, suggesting that this group could have been served as an immediate progenitor for B. mori. For further robust inference more analysis is underway.