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- 저자 : Jean-Claude Marie (검색결과 6 건)
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Claude L. Leger,Manijeh Shafiee,Marie-Annette Carbonneau,Jean-Baptiste d'Huart,Bernard Descomps 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.2
Using an approach in line with that of a previous report, we assessed the antioxidant activ-ity of several natural, polyphenol- or tocotrienol-rich mixtures: extracts from Elaesis Guineen-sis oil (A) and Vitis vinifera (B), a Coffea robusta powder (C), and extracts from Olea europeamill wastewaters (D), Solanum melongena (E), and Lycopersicon esculentum (F). The copper-and 2-29-azobis(2-amidinopropane) hydrochloride (AAPH)-oxidation systems were used inthe presence of low-density lipoprotein. For comparison, antioxidant activities of chlorogenicacid and catechin, as archetypes of molecules highly efficient with the coper- and the APH-oxidation system, respectively, were assessed. The aim was to establish the occurrence of syn-ergistic antioxidant actions among some of these natural mixtures. On a molar basis, the high-est specific antioxidant activities (SAA) were found for B, chlorogenic acid, and C in the coppersystem, and for A, catechin, and B in the AAPH system. On a mass basis, the highest SAwere found, respectively, for chlorogenic acid, B, and catechin, and for catechin, chlorogenicacid, and B. These results show that large discrepancies take place in the evaluations betwenthe two systems. B and C exhibited a synergistic antioxidant efficiency, in the presence or ab-sence of A, but only with the copper system. This was also true for the two types of A 1 B1 Cmixture that were tested. It is thought that this association might provide an ideal combina-tion, incorporating both the radical scavenger and the transition-metal ion chelation proper-ties of B and C.69
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Designing agenerichuman-machineframeworkforreal-timesupply chain planning
Jonathan Gaudreault,Claude-Guy Quimper,Philippe Marie,Mathieu Bouchard,François Chéné,Jean Bouchard 한국CDE학회 2017 Journal of computational design and engineering Vol.4 No.2
Mixed-Initiative-Systems (MIS)arehybriddecision-makingsystemsinwhichhumanandmachinecollaborateinordertoproduceasolution. This paperdescribedanMISadaptedtobusinessoptimizationproblems.Theseproblemscanusuallybesolvedinlessthananhourastheyshowa linearstructure.However,thisdelayisunacceptableforiterativeandinteractivedecision-makingcontextswhereusersneedtoprovidetheirinput. Therefore,weproposeasystemprovidingthedecision-makerswithaconvexhullofoptimalsolutionsthatminimize/maximizethevariables ofinterest.Theuserscaninteractivelymodifythevalueofavariableandthesystemisabletorecomputeanewoptimalsolutioninafew milliseconds.Fourreal-timereoptimizationmethodsaredescribedandevaluated.Wealsoproposeanimprovementtothisbasicschemeinorder toallowausertoexplorenear-optimalsolutionsaswell.Examplesshowingrealcaseofhowwehaveexploitedthisframeworkwithininteractive decisionsupportsoftwarearegiven.
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Jamel El-Benna,Pham My-Chan Dang,Marie-Anne Gougerot-Pocidalo,Jean-Claude Marie,Françoise Braut-Boucher 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.4
Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of neutrophils is based on the production of superoxide anion (O2 -), which generates other microbicidal reactive oxygen species (ROS) and release of antimicrobial peptides and proteins. The enzyme responsible for O2 - production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation. NADPH oxidase activation in phagocytes can be induced by a large number of soluble and particulate agents. This process is dependent on the phosphorylation of the cytosolic protein p47phox. p47phox is a 390 amino acids protein with several functional domains: one phox homology (PX) domain, two src homology 3 (SH3) domains, an auto-inhibitory region (AIR), a proline rich domain (PRR) and has several phosphorylated sites located between Ser303 and Ser379. In this review, we will describe the structure of p47phox, its phosphorylation and discuss how these events regulate NADPH oxidase activation. Phagocytes such as neutrophils play a vital role in host defense against microbial pathogens. The anti-microbial function of neutrophils is based on the production of superoxide anion (O2 -), which generates other microbicidal reactive oxygen species (ROS) and release of antimicrobial peptides and proteins. The enzyme responsible for O2 - production is called the NADPH oxidase or respiratory burst oxidase. This multicomponent enzyme system is composed of two transmembrane proteins (p22phox and gp91phox, also called NOX2, which together form the cytochrome b558) and four cytosolic proteins (p47phox, p67phox, p40phox and a GTPase Rac1 or Rac2), which assemble at membrane sites upon cell activation. NADPH oxidase activation in phagocytes can be induced by a large number of soluble and particulate agents. This process is dependent on the phosphorylation of the cytosolic protein p47phox. p47phox is a 390 amino acids protein with several functional domains: one phox homology (PX) domain, two src homology 3 (SH3) domains, an auto-inhibitory region (AIR), a proline rich domain (PRR) and has several phosphorylated sites located between Ser303 and Ser379. In this review, we will describe the structure of p47phox, its phosphorylation and discuss how these events regulate NADPH oxidase activation.
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Humic Acid and Glucan: Protection Against Liver Injury Induced by Carbon Tetrachloride
Vaclav Vetvicka,Jose M. Garcia-Mina,Mary Proctor,Jean-Claude Yvin 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.5
Humic acids (HAs) have a rather pleiotropic presence, however, their biological effects are still unclear. In this study, we focused on possible hepatoprotective effects of either HA alone or in combination with b-glucan. Using a model of experimental hepatotoxicity caused by carbon tetrachloride (CCL4), we showed that both HA and the glucan-HA combination offered significant protection against hepatotoxicity, with the combination offering superior effects. Our biochemical observations were confirmed by histological evaluation. Based on the experimental data, we conclude that whereas HA has significant effects, the synergy with glucan offers superior effects.
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Thermo-oxidation behaviour of organic matrix composite materials at high temperatures
Cinquin, Jacques,Colin, Xavier,Fayolle, Bruno,Mille, Marion,Terekhina, Svetlana,Chocinski-Arnault, Laurence,Gigliotti, Marco,Grandidier, Jean-Claude,Lafarie-Frenot, Marie-Christine,Minervino, Matteo,C Techno-Press 2016 Advances in aircraft and spacecraft science Vol.3 No.2
The present paper is a review of the main activities carried out within the context of the COMPTINN' program, a joint research project founded by a FUI program (Fonds $Unifi{\acute{e}}s$ $Interminist{\acute{e}}riels$) in which four research teams focused on the thermo-oxidation behaviour of HTS-TACTIX carbon-epoxy composite at 'high' temperatures ($120^{\circ}C-180^{\circ}C$). The scientific aim of the COMPTINN' program was to better identify, with a multi-scale approach, the link between the physico-chemical mechanisms involved in thermo-oxidation phenomena, and to provide theoretical and numerical tools for predicting the mechanical behaviour of aged composite materials including damage onset and development.
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