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( Lieu Such Chow ),( Young Jag Kwon ),( Se Jin Jean ),( So Hyun Joe ),( Kid Chan Kim ),( Jade Hon Cueing ),( Geon Jo Bah ),( Hahn Young Kim ),( Seal Hue Han ),( Chan Young Shin ),( Sung All Yang ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.2
Plasminogen activator inhibitir-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue Plasminogen activator (tap). In CNS, tPA/PAI1 antiviral. To gain a more insights into the regulatory mechanism modulating tap/PAI-1 activity in brain, we investigated the effects of protease inhibitors on tPA/PAI-1 expression and activity in rat primary as-Able peptde-aldehyde inhibitir-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue Plasminogen activator (tap). In CNS, tPA/PAI1 antiviral. To gain a more insights into the regulatory mechanism modulating tap/PAI-1 activity in brain, we investigated the effects of protease inhibitors on tPA/PAI-1 expression and activity in rat primary as-The induction of PAI-1 down regulated tap activity in rat primary astrocytes. Another protease inhibitor lactacystin similarly Inhibitir-1 (PAI-1) is a member of serine protease inhibitor family, which regulates the activity of tissue Plasminogen activator (tap). In CNS, tPA/PAI1 antiviral. To gain a more insights into the regulatory mechanism lactacystin and well In rat primary atrocities may underlie the observed CNS effects of MG132such as neuro protection.
A nickel(ii) complex under water-oxidation reaction: what is the true catalyst?
Feizi, Hadi,Bagheri, Robabeh,Jaglič,ić,, Zvonko,Singh, Jitendra Pal,Chae, Keun Hwa,Song, Zhenlun,Najafpour, Mohammad Mahdi The Royal Society of Chemistry 2019 Dalton transactions Vol.48 No.2
<P>In the present study, the water-oxidizing activity of nickel(ii) phthalocyanine-tetrasulfonate tetrasodium (1), which is a stable Ni(ii) complex under moderate conditions, was investigated. The role of Ni oxide in water oxidation as a true catalyst was investigated. The electrodes after water oxidation by both the complex and Ni salt were analyzed and a relation was proposed between the decomposition of the Ni complex and water oxidation. On the surface of the electrode, there are some areas without any detectable nanoparticles; thus, the detection of such Ni oxides on the surface of the electrode is not easy in the first seconds of the reaction, even using some of the usual methods such as Scanning Electron Microscopy or electrochemical analysis. Such experiments indicated that a precise analysis is necessary to reject the role of nanoparticles in the presence of Ni phthalocyanine under water oxidation. The findings also showed that under water-oxidation conditions and in the presence of the complex, Ni oxide is a good candidate for a true catalyst.</P>
보건소 금연클리닉 금연성공자의 1년내 재흡연과 관련요인
김미작,정인숙,Kim, Mi-Jag,Jeong, Ihn-Sook 대한예방의학회 2011 예방의학회지 Vol.44 No.2
Objectives: This study aimed to investigate smoking relapse and the related factors within 1 year after discharge from the smoking cessation clinics (SCCs) of public health centers (PHCs). Methods: Data were collected with a structured questionnaire from 395 people who success fully stopped smoking at 4 SCCs in Busan between May and June 2009, and this data were analyzed by Kaplan-Meier survival curves and the Cox proportional hazard model. Results: The rate of smoking relapse within 1 year after discharge from SCCs was 39.2% and this decreased rapidly over 6 months after discharge. The factors related to smoking relapse within 1 year after discharge from SCCs were being female (HR, 2.11; 95% CI, 1.17 to 3.82), a trial of smoking cessation with any assistants (HR, 1.95; 95% CI, 1.19 to 3.19), more than 7 ppm of exhaled CO2 on the SCCs' registration (HR, 1.81; 95% CI, 1.24 to 2.64), use of pharmacotherapy after discharge from SCCs (HR, 2.00; 95% CI, 1.36 to 2.93), alcohol drinking more than once a week after discharge from SCCs (HR, 3.32; 95% CI, 2.15 to 6.78), and a perceived barrier (HR, 1.21; 95% CI, 1.14 to 1.30) after discharge from the SCCs. Conclusions: According to the results, at least 6 months follow-up after discharge from SCCs of public health centers is recommended to reduce the rate smoking relapse. It is also recommended to strengthen the education on how to overcome barriers such as drinking in the course of smoking cessation clinics.
Parvin Kumar,Ashwani Kuamr,Late Jag Mohan,K. Makrandi 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
Condensation of 4-amino-5-mercapto-3-(α-naphthyl)-s-triazole (1) with cyanogen bromide gives 6-amino-3-(α-naphthyl)-s-triazolo[3,4-b]-1,3,4-thiadiazole (2) which on condensation with chloranil yields 3,9-di-(α-naphthyl)-6,14-dioxo-bis-(s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]cyclohexane]-5a,6a-diene) (3). 3-(α-naphthyl)-s-triazolo[3,4-b]-1,3,4-thiadiazolo[3,2-b]imidazo[4,5-b]quinoxaline (4) is obtained by a similar condensation of (2)with 2,3-dichloroquinoxaline. The reaction of (2) with α-haloketones followed by bromination affords 7-aryl-3-(α-naphthyl)-imidazo[2,1-b]-1,3,4-thiadiazolo[2,3-c]-s-triazoles (5) and their 6-bromo analogues 6 respectively. The structures of all newly synthesized compounds were established on the basis of elemental analyses, IR, 1H-NMR. The antibacterial and antifungal activities of all newly synthesized compounds have also been evaluated.