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최정현,김재백,고건일,손동환 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
Felbinac is an effective non-steroidal anti-inflammatory drug used topically for the treatment of sprains, strains and soft tissue injuries. The patch was prepared with an impermeable backing layer and an adhesive matrix using Primal^(??), Acrysol^(??), some enhancers, solvents and felbinac. A peel test of the patch showed variable peel strengths ranging from 160 to 550g/12mm(width) in differing compositions. The polysorbate 80 and HCO-40 had lessening effects with decreasing peel strengths. The drug release rate from the patch was more than 50% in 4 hours and approximately 100% in 12 hours. The patch contained enhancer, linoleic acid or oleic acid, showed increasing effect on the permeation rate through the hairless mouse skin in vitro. In another experiment, skin permeation from the patch was increased according to dose. In a pharmacokinetic study of the patch, T_(max) and C_(max) were respectively 9 hours and 78.6ng/ml. The AUC_(0-24h) was 1.38㎍·hr/ml. The felbinac patch displayed higher drug absorption compared to the ointment. In conclusion from the above results, it was considered that the felbinac patch was useful as a NSAIDs, more effective than oinment, avoiding systemic side-effects.