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Clinical Characteristics of Primary Peritoneal Carcinoma
Sang Young Roh,Sook Hee Hong,Yoon Ho Ko,Tae Hee Kim,Myung Ah Lee,Byoung Yong Shim,Jae Ho Byun,In Sook Woo,강진형,Young Seon Hong,Kyung Shik Lee 대한암학회 2007 Cancer Research and Treatment Vol.39 No.2
Purpose: The goal of this study was to determine the clinical and therapeutic characteristics of women with a primary peritoneal carcinoma (PPC).Materials and Methods: A retrospective clinical study was conducted to evaluate 22 women diagnosed with a PPC from 1993 to 2007 at the Hospitals of The Catholic University of Korea. Diagnoses were based on the Gynecologic Oncology Group criteria and clinical data. We collected patient clinicopathological data including age, presenting symptoms, pretreatment CA-125 values (U/ml), clinical stage (based on the FIGO stage), performance status (using the Eastern Cooperative Oncology Group scale), whether cytoreductive surgery was optimal or not, types of chemotherapy and response to treatment. We evaluated the clinical characteristics and response to treatment, time to treatment failure and overall survival.Results: The median overall survival of all patients was 23.1 months. The estimated 3-year survival rate was 29% (SE, 13%). The response rate to first-line platinum-based chemotherapy was 79% and the median time to treatment failure was 9.9 months (95% confidence interval, 1.38~18.4 months). By univariate and multivariate analysis, performance status was the only significant factor associated with overall survival (p〈0.05).Conclusion: We evaluated the clinical characteristics and treatment response of patients with a primary peritoneal carcinoma. Our results showed that it is possible to achieve long-term survival in patients with PPC. A further clinical study is to need to establish clinical characteristics and treatment outcomes. (Cancer Res Treat. 2007;39:65-68)
Roh, Ju-Won,Kim, Bu Kyung,Lee, Chae Hyeong,Kim, Jongseung,Chung, Hyun Hoon,Kim, Jae Weon,Park, Noh-Hyun,Song, Yong-Sang,Park, Sang-Yoon,Kang, Soon-Beom Pergamon Press 2009 Oncology Research Vol.18 No.9
<P>The aims of this study were to evaluate the genotype frequencies of p53 codon 72 and p21 codon 31 in cervical adenocarcinoma patients and controls, and the association between the specific genotype or genotype combination of these polymorphisms and the risk of cervical adenocarcinoma in Korean women. Genotyping was performed using DNA from cervical biopsy specimens collected from 53 patients with cervical adenocarcinoma, of whom 34 were HPV 16 or 18 positive, and from the cervical exfoliated cells from 286 control women, of whom 48 were positive for HPV 16 or 18. For the determination of p53 polymorphisms genomic DNA was examined by PCR amplification of the specific allele assay, and for the determination of p21 polymorphisms DNA was examined by the PCR-RFLP assay using BsmAI. We found significant differences in genotype frequencies of both genes between the two groups (p < 0.001). The p53 genotypes containing the Pro allele were significantly associated with cervical adenocarcinoma with an OR of 2.89 (95% CI 1.54-5.42). Also, homozygous carriers of the p21 Ser allele showed a substantially increased risk of developing cervical adenocarcinoma (OR 2.07; 95% CI 1.13-3.79) compared to genotypes containing the Arg allele. In addition, the combination of the Pro allele containing genotypes of p53 and the Ser homozygous genotype of p21 posed a remarkably increased risk (OR 5.22; 95% CI 2.24-12.16), although the interaction of the two genes could not be found. These significant differences were intensified in groups with high-risk HPV infection (types 16 or 18).</P>
HCC : O-048 ; Laparoscopic liver resection for T1 and T2 hepatocellular carcinoma
( Sang Hyun Song ),( Choon Hyuck David Kwon ),( Jae Won Joh ),( Jong Man Kim ),( Milljae Shin ),( Sung Joo Kim ),( Suk Koo Lee ),( Tae Suk Kim ),( Hyung Hwan Moon ),( Young Nam Roh ),( Sang Hoon Lee ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Laparoscopic liver resection has gained much popularity in recent years, but relatively few centers have performed laparoscopic hepatectomies in hepatocellular carcinoma (HCC) patients due to the technical difficulties. We now present our early experience with laparoscopic liver resection in HCC performed in a single institution. Methods: From January 2008 until February 2011, total 761 patients of hepatectomy was done and we excluded TNM stage 3, tumors over 5cm and location of tumors of segment I, VII, VIII. 84 laparoscopic liver resections were performed and open conversion was 13 cases (15.4%). To reduce selection bias we made a propensity case matching and selected 50 pairs of each operation group. Results: The cause of open conversion were bleeding for 7 cases, inability to find a mass for 3 cases, severe adhesion for 2 cases and tumor margin for 1 case. Preoperative variables of each group were comparable. The length of hospital stay was shorter in laparoscopic resection group than open resection group. (9.5 days vs 13.2 days, p=0.018) Disease free survival was not different with each group and overall survival was also comparable. 3 year disease free survival in laparoscopic resection group was 35.3% and open resection group was 51.6%. (p=0.409) 3 year survival rate in laparoscopic resection group was 81.3% and open resection group was 90.2%. (p=0.590) Conclusions: Laparoscopic liver resection for HCC can be a feasible and safe operative method in early stage HCC. To draw a final conclusion, randomized control study and long term follow up is needed.