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무궁화 꽃을 이용한 Alginine 선택성 sensor 개발에 관한 연구
김의락,손병기,남기재,최성문,전희숙,배진현 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1
It is shown that the rose of sharon receptacle tissue can serve as an effective biocatalyst in the construction of a potentiometric membrane electrode with response and selectivity for arginine, Electrodes using this tissue in conjunction with NH_(3) gas sensing probes yield good response to arginine in 1 X 10^(-1)M to 10^(-3)M range and retain activity for at least 2 weeks. The arginine-selective membrane electrode using tissue slices of the rose of sharon have good selectivity when operated at an optimum pH 8.0, 25℃, 20um thickness of slices and in 0.1M phosphate buffer solution.
쥐의 조직을 이용한 glutamine 선택성 sensor 개발에 관한 연구
김의락,손병기,임동준,배진현,최성문 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1
The various types of enzyme have been coupled to ion-selective electrodes for the development of enzyme membrane electrodes. The tissue and organ of animals and plants contained a lot of variant enzymes. A bioselsoective membrane electrode which employs slices of Wistar rat liver was studied that the effect of pH, kinds and concentration of buffer solution, temperature and thickness of slice in order to optimize electrode response. The longstability, the response time and slope of wistar rat tissue glutamine selective membrane electrode was evaluated.
남미의 경제통합과 새로운 지역주의화 : MERCOSUR를 중심으로
심의섭,주석배 明知大學校 經濟硏究所 2002 경영연구 Vol.21 No.1
1990년대 초반을 지나면서 자유무역을 확대하여 자국의 이익을 추구하려는 선진국의 노력은 세계화를 가속화시켰고, 자국의 이익을 도모하려는 특정지역의 상호협력은 지역화 현상으로 나타났다. 이러한 조류에 따라 남미공동시장(MERCOSUR)도 1991년에 새로이 출범하였다. MERCOSUR는 처음부터 국가별, 산업별 보완관계를 증진하기 위해 물리적인 통합을 하였으며, 회원국간의 경제적 상호의존도의 증가로 역내교역도 증대되었고, 1995년 이래 내부적인 국가별 에너지 및 운송 관련 사회간접자본 투자에 의한 지역적 네트워크를 구축하여 산업통합을 꾀하였다. 또한 2006년까지로 계획된 대외공동관세의 통일은 최근의 개별 회원국과 제3국간의 양자협정의 체결로 지장을 받고 있지만, 이러한 상황에서도 MERCOSUR은 개방적 지역주의에 따라 인접국가들인 칠레와 볼리비아를 끌어 들여 협력체를 확대하고, EU와도 자유무역지대의 형성을 추진하는가 하면, 향후 남미자유무역지대(SAFTA)와 미주 자유무역지대(FTAA) 설립 등 대륙간 경제통합의 광역화를 추진하고 있다.
Bae, Ui-Jin,Park, Eun-Ock,Park, John,Jung, Su-Jin,Ham, Hyeonmi,Yu, Kee-Won,Park, Young-Jun,Chae, Soo-Wan,Park, Byung-Hyun World Scientific Publishing Company 2018 The American journal of Chinese medicine Vol.46 No.6
<P>Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. <I>Gynostemma pentaphyllum</I> extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supplemented with various doses of UL4-rich GPE for eight weeks. GPE supplementation suppressed oxidative stress induced by the MCD diet by increasing levels of sirtuin 6 and phase 2 anti-oxidant enzymes in mouse liver and HepG2 cells. Additionally, GPE supplementation prevented diet-induced hepatic fat accumulation, hepatocellular injury, inflammation, and fibrosis in mice fed the MCD diet. These results indicate the possible therapeutic potential of dietary supplementation of UL4-rich GPE in preventing the development of fatty liver and its progression to NASH.</P>
Bae, Ui-Jin,Jung, Eun-Soo,Jung, Su-Jin,Chae, Soo-Wan,Park, Byung-Hyun Open Academia 2018 Food & nutrition research Vol.62 No.-
<P><B>Background</B></P><P>Augmenting glucose utilization in skeletal muscle <I>via</I> the phosphatidylinositol-3 kinase (PI3 kinase)/protein kinase B (Akt) pathway or the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway is necessary to regulate hyperglycemia in patients with type 2 diabetes mellitus.</P><P><B>Objective</B></P><P>We investigated the effect of mulberry leaf extract (MLE) on glucose uptake in skeletal muscle cells and explored its <I>in vivo</I> antidiabetic potential.</P><P><B>Design</B></P><P>Male <I>db/db</I> mice were treated with either MLE (50 mg/kg, 100 mg/kg, and 250 mg/kg) or metformin (100 mg/kg) for 8 weeks.</P><P><B>Results</B></P><P>MLE treatment stimulated glucose uptake, driven by enhanced translocation of glucose transporter 4 to cell membranes in L6 myotubes. These effects of MLE were synergistic with those of insulin and were abolished in the presence of PI3K inhibitor or AMPK inhibitor. In <I>db/db</I> mice, supplementation with MLE decreased fasting blood glucose and insulin levels and enhanced insulin sensitivity, with increases of p-Akt and p-AMPK in skeletal muscle. Moreover, MLE improved blood lipid parameters and attenuated hepatic steatosis in diabetic <I>db/db</I> mice.</P><P><B>Discussion</B></P><P>These findings suggest that MLE exerts antidiabetic activity through stimulating glucose disposal in skeletal muscle cells <I>via</I> the PI3K/Akt and AMPK pathways.</P><P><B>Conclusions</B></P><P>MLE can potentially improve hyperglycemia and hepatic steatosis in patients with type 2 diabetes.</P>
Hypoglycemic effects of aqueous persimmon leaf extract in a murine model of diabetes
BAE, UI-JIN,PARK, SOO-HYUN,JUNG, SU-YOUNG,PARK, BYUNG-HYUN,CHAE, SOO-WAN SPANDIDOS PUBLICATIONS 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.2
<P>Previously, powdered persimmon leaves have been reported to have glucose- and lipid-lowering effects in diabetic <I>(db/db)</I> mice. As persimmon leaf is commonly consumed as tea, an aqueous extract of persimmon leaves (PLE) was prepared and its anti-diabetic efficacy was investigated. In the present study, PLE was tested for its inhibitory activity on α-glucosidase <I>in vitro</I>. An oral maltose tolerance test was performed in diabetic mice. Next, the acute effect of PLE was examined in streptozotocin-induced diabetic mice. Last, the long-term effect of PLE supplementation was assessed in <I>db/db</I> after eight weeks. An oral glucose tolerance test, biochemical parameters, as well as histological analyses of liver and pancreas were evaluated at the end of the study. PLE inhibited α-glucosidase activity and increased antioxidant capacity. Streptozotocin-induced diabetic mice pre-treated with PLE displayed hypoglycemic activity. Daily oral supplementation with PLE for eight weeks reduced body weight gain without affecting food intake, enhanced the glucose tolerance during the oral glucose tolerance test (OGTT), improved blood lipid parameters, suppressed fat accumulation in the liver and maintained islet structure in <I>db/db</I> mice. Further mechanistic study showed that PLE protected pancreatic islets from glucotoxicity. In conclusion, the results of the present study indicated that PLE exhibits considerable anti-diabetic effects through α-glucosidase inhibition and through the maintenance of functional β-cells. These results provided a rationale for the use of persimmon leaf tea for the maintenance of normal blood glucose levels in diabetic patients.</P>