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Graham, I.,Hamada, H.,Honda, T.,Kohr, G.,Shon, K.H. Academic Press 2014 Journal of mathematical analysis and applications Vol.416 No.1
Let X be a complex Banach space with the unit ball B. The family M is a natural generalization to complex Banach spaces of the well-known Caratheodory family of functions with positive real part on the unit disc. We consider subfamilies M<SUB>g</SUB> of M depending on a univalent function g. We obtain growth theorems and coefficient bounds for holomorphic mappings in M<SUB>g</SUB>, including some sharp improvements of existing results. When g is convex, we study the family R<SUB>g</SUB> consisting of holomorphic mappings f:B→X which have the property that the mapping Df(z)(z) belongs to M<SUB>g</SUB>. Further, we consider radius problems related to the family R<SUB>g</SUB>, when X is a complex Hilbert space. In particular, if X is the Euclidean space C<SUP>n</SUP>, we obtain some quasiconformal extension results for mappings in R<SUB>g</SUB>. We also obtain some sufficient conditions for univalence and starlikeness in complex Banach spaces.
Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin
Park, T.Y.,Kim, S.H.,Shin, Y.C.,Lee, N.H.,Lee, R.K.C.,Shim, J.H.,Glimcher, L.H.,Mook-Jung, I.,Cheong, E.,Kim, W.K.,Honda, F.,Morio, T.,Lim, J.S.,Lee, S.K. Elsevier Science Publishers 2013 Journal of controlled release Vol.166 No.3
Inhibition of the early intracellular event that triggers neurodegenerative cascades and reversal of neuronal cell death are essential for effective treatment of Alzheimer's disease (AD). In this study, a novel therapeutic for AD, a transducible humanin with an extended caspase-3 cleavage sequence (tHN-C3), was developed and showed multiple mechanisms of therapeutic action. These included targeted delivery of anti-apoptotic protein humanin through the blood-brain barrier (BBB) to neuronal cells, specific inhibition of caspase-3 activation to inhibit the early triggering of AD progression, and delivery of humanin into the cytoplasm of neuronal cells undergoing apoptosis where it exerts its anti-apoptotic functions effectively. The tHN-C3 prevented neuronal cell death induced by H<SUB>2</SUB>O<SUB>2</SUB>, or soluble Aβ<SUB>42</SUB>, via Bax binding. In animal models of AD induced by amyloid beta, in Tg2576 mice, and in the rat middle cerebral artery occlusion model of stroke, tHN-C3 effectively prevented neuronal cell death, inflammatory cell infiltration into the brain, and improved cognitive memory. The therapeutic effectiveness of tHN-C3 was comparable to that of Aricept, a clinically approved drug for AD treatment. Therefore, tHN-C3 may be a new remedy with multiple therapeutic functions targeting the early and late stages of neurodegeneration in AD and other brain injuries.