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Status of the Development of OECD Test Method Detecting EDCs
Hyeyeong Seo,Huiwon Seo,Seungjoo Baik,Yejin Kim,Ahreum Seo,Seok-Hee Lee,Nick Byrd,Yooheon Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Endocrine Disrupting Chemicals (EDCs) are chemicals that interfere with endocrine function. These ‘disruptions’ can sometimes cause devastating problems such as attention deficit disorder, breast cancer, prostate cancer, thyroid cancer, feminizing men in men, or virilizing effects in women. Based on the need for the management of EDCs, the OECD Advisory Group on Endocrine Substance Testing and Evaluation discussed the development and update of test guidelines and related documents for Endocrine Substance Testing and Evaluation. Certain OECD test guidelines using laboratory animals already addressed toxicity to the hormonal system. However, with increasing awareness of animal welfare, the OECD strongly recommends supporting the development of non-animal test applicable to the screening and evaluation of EDCs. Various alternative animal test methods have been established as OECD-approved test methods (so called Test Guidelines), and Korea is also making great efforts. In this session, the OECD accreditation process and the current status of test method development will be discussed.
Ahreum Seo,Seok-Hee Lee,Hyeyeong Seo,Huiwon Seo,Seungjoo Baik,Yejin Kim,Yooheon Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Biocide refers to a substance used to remove harmful organisms other than humans and animals, and non-agricultural pesticides, disinfectants, and disinfectants (preservatives, preservatives, antibacterial agents) have been used. Some biocidal chemicals bind to estrogen receptors to imitate, block, or inhibit the estrogen. In this study, we selected 13 substances, including Vinclozolin, Atrazine, and Ketoconazole, well-known as pesticides, among 78 chemicals that the ICCVAM recommended the possibility of endocrine activity in estrogen and androgen. To evaluate estrogenic activity, which is part of the AOP framework, we used the previously developed Bioluminescence Resonance Energy Transfer (BRET)-based Estrogen Dimerization Assay (DA) and OECD Transactivation Assay (TA, TG 455). As a result, one of the 13 chemicals of biocides did not form a dimer in the BRET based-estrogen DA but showed antagonism in the TA. This results not only provided scientific information on the toxicity pathways of biocide chemicals that have not been previously presented, but also suggested the need for research on pathways other than those affecting typically known estrogen receptor transactivation.
Yejin Kim,Seok-Hee Lee,Hyeyeong Seo,Huiwon Seo,Seungjoo Baik,Ahreum Seo,Yooheon Park 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The skeletal system completes as the body grows, especially bone mass, which is mostly formed during puberty. Osteoporosis develops as lose the balance of bone formation and bone resorption processes due to the loss of bone mass. Therefore, it is very important to maintain the balance of bone formation and bone resorption processes and form ‘good-quality’ bones through proper nutrient intake from adolescence. In this study, it was confirmed whether organic whole milk powder (OWMP) and colostrum basic protein (CBP) were effective for skeletal growth. Individual effects and interaction effects of OWMP and CBP were confirmed in ovariectomzed rat model. The experimental diet was designed so that total calories, protein content, and fat-derived calories were even. CBP and OWMP were included in the diet at 0.1% and 10%, respectively. To confirm the skeletal growth efficacy of organic whole milk powder (OWMP) and colostrum protein (CBP), bone parameters were evaluated by microCT, and bone serum parameters were evaluated by measuring blood Ca and P concentrations. Osteoblast-osteoclast related factors in serum were also identified toi confirm the effect.
Jo, Hyeyeong,Son, Min-Hui,Seo, Sung-Hee,Chang, Yoon-Seok Elsevier 2017 Environmental pollution Vol.226 No.-
<P><B>Abstract</B></P> <P>Hexabromocyclododecane (HBCD) contamination and its diastereomeric profile were investigated in a multi-media environment along a river at the local scale in air, soil, sludge, sediment, and fish samples. The spatial distribution of HBCD in each matrix showed a different result. The highest concentrations of HBCD in air and soil were detected near a general industrial complex; in the sediment and sludge samples, they were detected in the down-stream region (i.e., urban area). Each matrix showed the specific distribution patterns of HBCD diastereomers, suggesting continuous inputs of contaminants, different physicochemical properties, or isomerizations. The particle phases in air, sludge, and fish matrices were dominated by α-HBCD, owing to HBCD's various isomerization processes and different degradation rate in the environment, and metabolic capabilities of the fish; in contrast, the sediment and soil matrices were dominated by γ-HBCD because of the major composition of the technical mixtures and the strong adsorption onto solid particles. Based on these results, the prevalent and matrix-specific distribution of HBCD diastereomers suggested that more careful consideration should be given to the characteristics of the matrices and their effects on the potential influence of HBCD at the diastereomeric level.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The spatial distribution and isomer profiles of HBCD were related to the matrix. </LI> <LI> The isomer profiles of HBCD reflected the different characteristics of each matrix. </LI> <LI> In air and soil, the potential sources impacted the spatial distribution. </LI> <LI> In the aqueous environment, spatial distribution influenced by other factors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>