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Controlling the drug-resistant tuberculosis epidemic in India: challenges and implications
Aliabbas A,Husain1,Andreas Kupz,Rajpal S,Kashyap 한국역학회 2021 Epidemiology and Health Vol.43 No.-
India has a higher tuberculosis (TB) burden than any other country, accounting for an estimated one-fourth of the global burden. Drug-resistant tuberculosis (DR-TB) presents a major public health problem in India. Patients with DR-TB often require profound changes in their drug regimens, which are invariably linked to poor treatment adherence and sub-optimal treatment outcomes compared to drug-sensitive TB. The challenge of addressing DR-TB is critical for India, as India contributes over 27% of global DR-TB cases. In recent decades, India has been proactive in its battle against TB, even implementing a revised National Strategic Plan to eliminate TB by 2025. However, to achieve this ambitious goal, the country will need to take a multifaceted approach with respect to its management of DR-TB. Despite concerted efforts made by the National TB Elimination Program, India faces substantial challenges with regard to DR-TB care, especially in peripheral and resource-limited endemic zones. This article describes some of the major challenges associated with mitigating the growing DR-TB epidemic in India and their implications.
Study of density of localized states in a-Ga x Se100-x alloysusing SCLC measurements
M. Husain,Shagufta B. Husain,M. Zulfequar,M.A. Majeed Khan 한국물리학회 2004 Current Applied Physics Vol.4 No.5
DC conductivity measurements have been made as a function of temperature and electric eld on a-GaxSe100-x (0≤x≤10)samples, in order to study the eect of the electric eld and temperature on the conduction mechanism. The present paper reports themeasurements on space charge limited conduction (SCLC) in vacuum evaporated amorphous thin lms of a-GaxSe100-x where 0≤x≤10. At high fields (~10⁴V/cm), the current could be tted to the theory of space charge limited conduction, in case ofuniform distribution of localized states in the mobility gap of these materials. The addition of Gallium (Ga) in a-GaxSe100-x results in an increase in the density of localized states and hence an increase in conductivity.
Gulam Mohammed Husain,Syed Shoeb Ahmed,Misbahuddin Azhar,Javed Inam Siddiqui,Mohammad Abdul Waheed,Munawwar Husain Kazmi 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.1
Background: Jawarish Jalinoos (JJ) is a classical semisolid traditional Unani formulation clinically used for the treatment of weakness of vital organs, liver, and stomach. Although JJ has been widely used clinically for several decades, no scientific report is available for its safety. Methods: JJ and its sugar-free tablet version (SFJJ; formulated to target diabetic population) were assessed for safety in rats. Ninety-day repeated dose oral toxicity study was performed as per the Organisation for Economic Co-operation and Development Guideline 408. JJ was orally administered at the dose of 2000 mg/kg bw/d, whereas SFJJ was orally administered at the doses of 506 mg/kg body weight (bw)/d, 1012 mg/kg bw/d, and 2024 mg/kg bw/d for 90 days. The animals were periodically observed for clinical signs of toxicity, mortality, morbidity, body weight changes, and feed consumption. At the end of the study, hematology, clinical biochemistry, electrolytes, gross pathology, relative organ weight, and histological examination were performed. Results: Treatment with SFJJ and JJ showed no significant differences in body weight gain, feed consumption, hematology, clinical biochemistry, and serum electrolytes. No gross pathological findings and differences in relative organ weights were observed between control and drug treated rats. Histological examination revealed no toxicologically significant abnormalities related with SFJJ or JJ treatment. Conclusion: The 90-day repeated dose oral toxicity study demonstrates that the no observed adverse effect level of SFJJ and JJ is greater than 2024 mg/kg bw/d and 2000 mg/kg bw/d (p.o.) in rats, respectively. Both formulations were found to be safe up to the tested dose levels and experimental conditions, and therefore safe for clinical use as specified in the literature.
NONDIFFERENTIABLE SECOND ORDER SELF AND SYMMETRIC DUAL MULTIOBJECTIVE PROGRAMS
Husain, I.,Ahmed, A.,Masoodi, Mashoob Korean Society of Computational and Applied Mathem 2008 Journal of applied mathematics & informatics Vol.26 No.3-4
In this paper, we construct a pair of Wolfe type second order symmetric dual problems, in which each component of the objective function contains support function and is, therefore, nondifferentiable. For this problem, we validate weak, strong and converse duality theorems under bonvexity - boncavity assumptions. A second order self duality theorem is also proved under additional appropriate conditions.
A Model to Identify Expeditiously During Storm to Enable Effective Responses to Flood Threat
Husain, Mohammad,Ali, Arshad International Journal of Computer ScienceNetwork S 2021 International journal of computer science and netw Vol.21 No.5
In recent years, hazardous flash flooding has caused deaths and damage to infrastructure in Saudi Arabia. In this paper, our aim is to assess patterns and trends in climate means and extremes affecting flash flood hazards and water resources in Saudi Arabia for the purpose to improve risk assessment for forecast capacity. We would like to examine temperature, precipitation climatology and trend magnitudes at surface stations in Saudi Arabia. Based on the assessment climate patterns maps and trends are accurately used to identify synoptic situations and tele-connections associated with flash flood risk. We also study local and regional changes in hydro-meteorological extremes over recent decades through new applications of statistical methods to weather station data and remote sensing based precipitation products; and develop remote sensing based high-resolution precipitation products that can aid to develop flash flood guidance system for the flood-prone areas. A dataset of extreme events has been developed using the multi-decadal station data, the statistical analysis has been performed to identify tele-connection indices, pressure and sea surface temperature patterns most predictive to heavy rainfall. It has been combined with time trends in extreme value occurrence to improve the potential for predicting and rapidly detecting storms. A methodology and algorithms has been developed for providing a well-calibrated precipitation product that can be used in the early warning systems for elevated risk of floods.
Alkaloids from The Roots of Tabernaemontana Macrocarpa Jack
Husain, Khairana,Said, Ikram M.,Din, Laily B.,Takayama, Hiromitsu,Kitajima, Mariko,Aimi, Norio The Korean Society of Pharmacognosy 1997 Natural Product Sciences Vol.3 No.1
The roots of Tabernaemontana macrocarpa Jack (Apocynaceae) yielded nine indole alkaloids which were identified as coronaridine (2), voacangine hydroxy-indolenine (3), 3-oxo-coronaridine (4), 19-R-heyneanine (7), coronaridine pseudoindoxyl (8) and voacangine pseudoindoxyl (9) while 3-(2-oxopropyl)-coronaridine (1), 3-(2-oxopropyl)-coronaridine-pseudoindoxyl (5) and 3-(2-oxopropyl)-voacangine-pseudoindoxyl (6) were isolated as artefacts formed during the isolation process. All of the alkaloids were identified by spectroscopic methods $(UV,\;MS,\;^1H-NMR\;&\;^{13}C-NMR)$ and in comparison with the literature data.
Husain, Aliabbas A.,Daginawala, Hatim F.,Warke, Shubangi R.,Kalorey, Devanand R.,Kurkure, Nitin V.,Purohit, Hemant J.,Taori, Girdhar M.,Kashyap, Rajpal S. The Korean Association of Immunobiologists 2015 Immune Network Vol.15 No.2
Evaluation and screening of vaccines against tuberculosis depends on development of proper cost effective disease models along with identification of different immune markers that can be used as surrogate endpoints of protection in preclinical and clinical studies. The objective of the present study was therefore evaluation of subcutaneous model of M.tuberculosis infection along with investigation of different immune biomarkers of tuberculosis infection in BALB/c mice. Groups of mice were infected subcutaneously with two different doses : high ($2{\times}10^6CFU$) and low doses ($2{\times}10^2CFU$) of M.tuberculosis and immune markers including humoral and cellular markers were evaluated 30 days post M.tuberculosis infections. Based on results, we found that high dose of subcutaneous infection produced chronic disease with significant (p<0.001) production of immune markers of infection like $IFN{\gamma}$, heat shock antigens (65, 71) and antibody titres against panel of M.tuberculosis antigens (ESAT-6, CFP-10, Ag85B, 45kDa, GroES, Hsp-16) all of which correlated with high bacterial burden in lungs and spleen. To conclude high dose of subcutaneous infection produces chronic TB infection in mice and can be used as convenient alternative to aerosol models in resource limited settings. Moreover assessment of immune markers namely mycobacterial antigens and antibodies can provide us valuable insights on modulation of immune response post infection. However further investigations along with optimization of study protocols are needed to justify the outcome of present study and establish such markers as surrogate endpoints of vaccine protection in preclinical and clinical studies in future.
ON FRACTIONAL PROGRAMMING CONTAINING SUPPORT FUNCTIONS
HUSAIN, I.,JABEEN, Z. 한국전산응용수학회 2005 Journal of applied mathematics & informatics Vol.18 No.1
Optimality conditions are derived for a nonlinear fractional program in which a support function appears in the numerator and denominator of the objective function as well as in each constraint function. As an application of these optimality conditions, a dual to this program is formulated and various duality results are established under generalized convexity. Several known results are deduced as special cases.
MIXED TYPE SECOND-ORDER DUALITY WITH SUPPORT FUNCTION
Husain, I.,Ahmed, A.,Masoodi, Mashoob The Korean Society for Computational and Applied M 2009 Journal of applied mathematics & informatics Vol.27 No.5
Mixed type second order dual to the non-differentiable problem containing support functions is formulated and duality theorems are proved under generalized second order convexity conditions. It is pointed out that the mixed type duality results already reported in the literature are the special cases of our results.