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Huquan Gao,Tian-Jiao Zhu,De-Hai Li,Qian Qun Gu,Weizhong Liu 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8
One new prenylated indole diketopiperazinealkaloid, named dihydroneochinulin B (1), one known spiropolyketide-diketopiperazine hybrid cryptoechinuline D (2)and three related known metabolites didehydroechinulin B(3), neoechinulin B (4) and auroglaucin (5) were isolatedfrom the mangrove rhizosphere soil derived fungus, Aspergilluseffuses H1-1. The structures were assigned by detailedspectroscopic analysis. The enantiomers of cryptoechinulineD (2) were separated to be (?)-cryptoechinuline D (2a) and(-)-cryptoechinuline D (2b) by chiral HPLC, and theirabsolute configurations were determined by ECD analysis. The cytotoxic effects of the compounds were preliminarilyevaluated on P388, HL-60, BEL-7402 and A-549 cell linesby SRB or MTT methods, and compounds 2, 2a and 3showed significant activities.
Two new meroterpenoids produced by the endophytic fungus Penicillium sp. SXH-65
Xinhua Sun,Xianglan Kong,Huquan Gao,Tianjiao Zhu,Guangwei Wu,Qianqun Gu,Dehai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.8
Two new meroterpenoids, arisugacins I (1) andJ (2), together with five known meroterpenoids includingarisugacin B (3), arisugacin F (4), arisugacin G (5), territremB (6) and territrem C (7) were isolated from anendophytic fungus Penicillium sp. SXH-65. Their structureswere determined by extensive spectroscopic experimentsand comparison with literature data. Theircytotoxicities were evaluated against Hela, HL-60 andK562 cell lines, and only 3 and 4 exhibited weak cytotoxicitiesagainst Hela, HL-60 and K562 cell lines withIC50 values ranging from 24 to 60 lM.