http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Reorganization of Southern Ocean Plankton Ecosystem at the Onset of Antarctic Glaciation
Houben, Alexander J. P.,Bijl, Peter K.,Pross, Jö,rg,Bohaty, Steven M.,Passchier, Sandra,Stickley, Catherine E.,Rö,hl, Ursula,Sugisaki, Saiko,Tauxe, Lisa,van de Flierdt, Tina,Olney, Matthew,San American Association for the Advancement of Scienc 2013 Science Vol.340 No.6130
<P><B>Southern Change</B></P><P>Antarctica has been mostly covered by ice since the inception of large-scale continental glaciation during the Oligocene, which profoundly altered the isotopic and mineralogical records of the sediments surrounding the continent. <B>Houben <I>et al.</I></B> (p. 341) found records of the corresponding living systems in the fossil marine dinoflagellate cysts, which revealed that a microplankton ecosystem, similar to the one that exists today, appeared simultaneously with the first major Antarctic glaciation approximately 34 million years ago.</P>
Systematic Genetic Nomenclature for Type VII Secretion Systems
Bitter, Wilbert,Houben, Edith N. G.,Bottai, Daria,Brodin, Priscille,Brown, Eric J.,Cox, Jeffery S.,Derbyshire, Keith,Fortune, Sarah M.,Gao, Lian-Yong,Liu, Jun,Gey van Pittius, Nicolaas C.,Pym, Alexand Public Library of Science 2009 PLoS pathogens Vol.5 No.10
Synthesis and Characterization of Pb@GaS Core–Shell Fullerene-Like Nanoparticles and Nanotubes
Olga Brontvein,Lothar Houben,RONIT POPOVITZ-BIRO,Moshe Levy,Daniel Feuermann,RESHEF TENNE,Jeffrey M. Gordon 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3
New types of core–shell nanoparticles are reported: Pb@GaS fullerene-like and nanotubular structures, achieved via the continuously high reactor temperatures and ultra-hot stronggradient annealing environments created by highly concentrated sunlight. Structural and chemical characterizations suggest a formation mechanism where vaporized Pb condenses into nanoparticles that are stabilized as they become covered by molten GaS, the ensuing crystallization of which creates the outer layers. Hollow-core GaS fullerene-like nanoparticles and nanotubes were also observed among the products, demonstrating that a single solar procedure can generate a variety of core–shell and hollow nanostructures. The proposed formation mechanisms can account for their relative abundance and the characterization data.
Michaël T.J. Peeters,Kim J.D. de Kort,Rik Houben,Wouter J.P. Henneman,Robert J. van Oostenbrugge,Julie Staals,Alida A. Postma 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.1
Background and Purpose: Spot sign (SS) on computed tomography angiography (CTA) is associated with hematoma expansion (HE) and poor outcome after intracerebral hemorrhage (ICH). However, its predictive performance varies across studies, possibly because differentiating hyperdense hemorrhage from contrast media is difficult. We investigated whether dual-energy-CTA (DE-CTA),which can separate hemorrhage from iodinated contrast, improves the diagnostic accuracy of SS for predicting HE. Methods: Primary ICH patients undergoing DE-CTA (both arterial as well as delayed venous phase) and follow-up computed tomography were prospectively included between 2014 and 2019. SS was assessed on both arterial and delayed phase images of the different DE-CTA datasets, i.e., conventional-like mixed images, iodine images, and fusion images. Diagnostic accuracy of SS for prediction of HE was determined on all datasets. The association between SS and HE, and between SS and poor outcome (modified Rankin Scale at 3 months ≥3) was assessed with multivariable logistic regression, using the dataset with highest diagnostic accuracy. Results: Of 139 included patients, 47 showed HE (33.8%). Sensitivity of SS for HE was 32% (accuracy 0.72) on conventional-like mixed arterial images which increased to 76% (accuracy 0.80) on delayed fusion images. Presence of SS on delayed fusion images was independently associated with HE (odds ratio [OR], 17.5; 95% confidence interval [CI], 6.14 to 49.82) and poor outcome (OR, 3.84;95% CI, 1.16 to 12.73). Conclusions: Presence of SS on DE-CTA, in particular on delayed phase fusion images, demonstrates higher diagnostic performance in predicting HE compared to conventional-like mixed imaging, and it is associated with poor outcome.
Dipanjan Chanda,Jieyi Li,Yvonne Oligschlaeger,Mike LJ Jeurissen,Tom Houben,Sofie MA Walenbergh,Ronit Shiri-Sverdlov,Dietbert Neumann 생화학분자생물학회 2016 Experimental and molecular medicine Vol.48 No.-
Non-alcoholic steatohepatitis (NASH), a metabolic disorder consisting of steatosis and inflammation, is considered the hepatic equivalent of metabolic syndrome and can result in irreversible liver damage. Macrophage-stimulating protein (MSP) is a hepatokine that potentially has a beneficial role in hepatic lipid and glucose metabolism via the activation of AMP-activated protein kinase (AMPK). In the current study, we investigated the regulatory role of MSP in the development of inflammation and lipid metabolism in various NASH models, both in vitro and ex vivo. We observed that MSP treatment activated the AMPK signaling pathway and inhibited lipopolysaccharide (LPS)- and palmitic acid (PA)-induced gene expression of pro-inflammatory cytokines in primary mouse hepatocytes. In addition, MSP treatment resulted in a significant reduction in PA-induced lipid accumulation and inhibited the gene expression of key lipogenic enzymes in HepG2 cells. Upon short hairpin RNA-induced knockdown of RON (the membrane-bound receptor for MSP), the anti-inflammatory and anti-lipogenic effects of MSP were markedly ablated. Finally, to mimic NASH ex vivo, we challenged bone marrow-derived macrophages with oxidized low-density lipoprotein (oxLDL) in combination with LPS. OxLDL+LPS exposure led to a marked inhibition of AMPK activity and a robust increase in inflammation. MSP treatment significantly reversed these effects by restoring AMPK activity and by suppressing pro-inflammatory cytokine gene expression and secretion under this condition. Taken together, these data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in NASH.