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The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese
Hongying Han,Xiaowei Xia,Huirong Zheng,Chongbang Zhao,Yanming Xu,Jiong Tao,Xianglan Wang 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.11
Objective To investigate the association between gene polymorphism of vesicular monoamine transporter type 2(VMAT2) and schizophrenia in Han Chinese population.Methods 430 patients with schizophrenia and 470 age-sex matched controls were recruited from four mental health centers. All patients were diagnosed by two psychiatrists based on the Structured Clinical Interview for DSM Disorders (SCID). The ligase detection reactions (LDR) method was used to assess the polymorphism of the two SNPs (rs363371 and rs363324) of VMAT2.Results No associations of two SNPs with schizophrenia was found. When we stratified males and females for the analysis, we found that that in the recessive model of rs363371, there was an obvious significant association between rs363371 and schizophrenia in males (OR=0.564, 95% CI=0.357–0.892, p=0.014) but not females. For the association between rs363324 and schizophrenia, no association was found in either males or females. No association was found when stratifying early-onset schizophrenia and late-onset schizophrenia.Conclusion Our findings indicate that both rs363371 and rs363324 were not associated with schizophrenia, while it seemed that the AA genotype of rs363371 plays a protective effect in male Chinese in developing schizophrenia.
Removal of Uranium from Uranium Plant Wastewater Using Zero-Valent Iron in an Ultrasonic Field
Jing Li,Libo Zhang,Jinhui Peng,Jinming Hu,Lifeng Yang,Aiyuan Ma,Hongying Xia,Wenqian Guo,Xia Yu 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.3
Uranium removal from uranium plant wastewater using zero-valent iron in an ultrasonicfield was investigated. Batch experiments designed by the response surface methodology(RSM) were conducted to study the effects of pH, ultrasonic reaction time, and dosage ofzero-valent iron on uranium removal efficiency. From the experimental data obtained inthis work, it was found that the ultrasonic method employing zero-valent iron powdereffectively removes uranium from uranium plant wastewater with a uranium concentrationof 2,772.23 mg/L. The pH ranges widely from 3 to 7 in the ultrasonic field, and theprediction model obtained by the RSM has good agreement with the experimental results.