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권병석,Byung-SamKim,HongRaeCho,Jeong-EuyPark,ByoungSeKwon 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.1
Current therapies for autoimmune diseases are notcures but merely palliatives, aimed at reducingsymptoms. For the most part, these treatmentsprovide nonspecific suppression of the immunesystem and thus do not distinguish between apathogenic autoimmune response and a protectiveimmune response. Recently emerging evidencenot only has indicated the involvement of membersof the TNF receptor/ligand superfamilies butalso has revealed exciting innovative strategies forthe treatment of autoimmune diseases and otherchronic inflammatory diseases without depressingthe immune response in general. In this review,we will discuss the regulatory mechanisms of TNFreceptor/ligand family members, such as HVEM/LIGHT, 4-1BB/4-1BBL, and GITR/GITRL that regulateT and B cell functions and participate in theprocess of inflammatory diseases. We will also discusshow intervening in the costimulatory pathwaysmediated by these molecules might havesome potential as a therapeutic approach to immunedisorders.
HyoWonJung,SuJinLa,JiYoungKim,SukKyeungHeo,JuYangKim,SaWang,KackKyunKim,KiManLee,HongRaeCho,HyeonWooLee,ByungsukKwon,ByungSamKim,ByoungSeKwon 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.6
Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor herpes simplex virus entry, in T cell activation and in tumor imunity. We generated mAb against HVEM and detected soluble HVEM (SHVEM) in the sera of patients with various autoimune diseases. HVEM was constitutively expresed on CD4+ and CD8+T cels, CD19+B cels, CD14+monocytes, neutrophils and dendritic cels. In thre-way MLR, mAb 122 and 139 were agonists and mAb 108 had blocking activity. An ELISA was developed to detect sHVEM in patient sera. sHVEM levels were elevated dermatitis and rheumatoid arthritis. The mAbs dis-cussed here may be useful for studies of the role of HVEM in imune responses. Detection of soluble HVEM might have diagnostic and prognostic value in certain imunological disorders.