High levels of soluble herpes virus entry mediator in sera of patients with allergic and autoimmune diseases

다국어 초록 (Multilingual Abstract)

Herpes virus entry mediator (HVEM) is a newly discovered member of the tumor necrosis factor herpes simplex virus entry, in T cell activation and in tumor imunity. We generated mAb against HVEM and detected soluble HVEM (SHVEM) in the sera of patients with various autoimune diseases. HVEM was constitutively expresed on CD4+ and CD8+T cels, CD19+B cels, CD14+monocytes, neutrophils and dendritic cels. In thre-way MLR, mAb 122 and 139 were agonists and mAb 108 had blocking activity. An ELISA was developed to detect sHVEM in patient sera. sHVEM levels were elevated dermatitis and rheumatoid arthritis. The mAbs dis-cussed here may be useful for studies of the role of HVEM in imune responses. Detection of soluble HVEM might have diagnostic and prognostic value in certain imunological disorders.