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Hojati, Seyedeh Fatemeh,Gholizadeh, Mostafa,Haghdoust, Mahnaz,Shafiezadeh, Fatemeh Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A new and efficient method for the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones via Biginelli synthesis using catalytic amounts of 1,3-dichloro-5,5-dimethylhydantoin is presented. Short reaction times, easy work-up, high yields of products and stability, easy-handling, non-toxicity and cheapness of the catalyst are noteworthy advantages of the present work.
Hojati, Seyedeh Fatemeh,Zeinali, Toktam,Nematdoust, Zahra Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
The reactions of indole with carbonyl groups have been efficiently carried out in the presence of catalytic amounts of 1,3-dibromo-5,5-dimethylhydantoin under solvent-free conditions and corresponding bis(indolyl)-mathanes were obtained in good to excellent yields. Synthesis of di[bis(indolyl)methyl]benzene was also accomplished by this catalyst. Furthermore, chemoselective conversion of aromatic aldehydes to their corresponding bis(indolyl)methanes in the presence of aliphatic aldehydes or ketones was achieved by this method.
Ali Hojati,Mahdieh Abbasalizad Farhangi 한국임상영양학회 2024 Clinical Nutrition Research Vol.13 No.1
Obesity and overweight pose a significant public health problem, as they are associated with an elevated risk of metabolic syndrome (MetS). Several studies have shown that diet quality is associated with the development of MetS risk factors. Analyzing dietary patterns may be more helpful in determining the relationship between eating habits and chronic diseases compared to focusing on single foods or nutrients. In this study, our objective was to evaluate the association of food quality score (FQS) with risk factors for MetS in individuals with obesity and overweight. The participants in this cross-sectional study were 340 adults with overweight and obesity. Participants’ food intake was measured using a Food Frequency Questionnaire, then the FQS was calculated. A fasting blood sample assessed serum glucose, triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, and serum insulin levels. Fat-free mass, height, basal metabolic rate, socio-economic score, and waist-to-hip ratio significantly differed among FQS tertiles. TC, systolic and diastolic blood pressure, and fasting blood glucose were significantly lower in the highest tertile of FQS. After multivariable adjustment, our results showed that individuals in the third tertile of FQS had reduced risk of higher levels of TC (odds ratio [OR], 0.982; 95% confidence interval [CI], 0.970–0.984) and higher levels of low-density lipoprotein cholesterol (OR, 0.974; 95% CI, 0.974–0.999). Our findings demonstrate an inverse relationship between diet quality, as measured by FQS, and MetS risk factors. However, further experimental and longitudinal investigations are warranted to elucidate the causal nature of this association.
Seyedeh Fatemeh Hojati,Mostafa Gholizadeh,Mahnaz Haghdoust,Fatemeh Shafiezadeh 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
A new and efficient method for the preparation of substituted 3,4-dihydropyrimidin-2(1H)-ones via Biginelli synthesis using catalytic amounts of 1,3-dichloro-5,5-dimethylhydantoin is presented. Short reaction times, easy work-up, high yields of products and stability, easy-handling, non-toxicity and cheapness of the catalyst are noteworthy advantages of the present work.
Hassan Bgheri Yazdi,Vida Hojati,Abdolhossein Shiravi,Sara Hosseinian,Gholamhassan Vaezi,Mousa-Al-Reza Hadjzadeh 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.2
Objectives: Oxidative stress plays a central role in diabetes-induced complications. In the present study, the protevtive effect of Artemisia turanica (A. turanica) was evaluated against diabetes-induced liver oxidative stress and dysfunction. Methods: Fifty male Wistar rats were randomly divided into five groups: control, diabetic, diabetic + metformin, diabetic + A. turanica extract, and diabetic + A. turanica extract + metformin. Experimental diabetes was induced by a single-dose (55 mg/kg, intraperitoneally (ip)) injection of streptozotocin (STZ). Metformin (300 mg/kg) and A. turanica extract (70 mg/kg) were orally administrated three days after STZ injection for four weeks. The levels of malondialdehyde (MDA), total thiol content and superoxide dismutase (SOD) and catalase activities were measured in the liver tissue. Serum glucose concentration, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were also determined. Results: In the diabetic group, serum glucose concentration, serum AST and ALT activities and liver MDA level were significantly higher while tissue total thiol content as well as catalase and SOD activities were lower, compared to the control group. Serum glucose in diabetic rats treated with metformin + A. turanica extract showed a significant decrease compared with the diabetic group. In all the A. turanica extract and metformin treated groups, serum ALT, tissue MDA level, total thiol content and SOD activity significantly improved compared with the diabetic rats. However, treatment of the diabetic rats only with metformin could not significantly change the activities of catalase and AST compared with the diabetic group. Conclusion: These findings suggested that A. turanica extract had a therapeutic effect on liver dysfuncyion and oxidative stress induced by diabetes, that may be probably due to its antioxidant and antiinflammatory effects.
Amirhosein Ramazanpour Esfahani,Saeid Hojati,Amin Azimi,Leila Alidokht,Alireza Khataee,Meysam Farzadian 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4
We studied the optimization of hexavalent chromium (Cr(VI)) removal from aqueous solution using thesynthesized zero-valent iron nanoparticles stabilized with sepiolite clay (S-ZVIN), under various parameters such asreaction time (min), initial solution pH and concentration of S-ZVIN (g·L−1) using response surface methodology (RSM). The kinetic study of Cr(VI) was conducted using three types of the most commonly used kinetic models including pseudozero-order, pseudo first-order, and pseudo second-order models. The rate of reduction reaction showed the best fitwith the pseudo first-order kinetic model. The process optimization results revealed a high agreement between the experimentaland the predicted data (R2=0.945, Adj-R2=0.890). The results of statistical analyses showed that reactiontime was the most impressive factor influencing the efficiency of removal process. The optimum conditions for maximumresponse (98.15%) were achieved at the initial pH of 4.7, S-ZVIN concentration of 1.3 g·L−1 and the reactiontime of 75 min.
Yazdi, Hassan Bgheri,Hojati, Vida,Shiravi, Abdolhossein,Hosseinian, Sara,Vaezi, Gholamhassan,Hadjzadeh, Mousa-Al-Reza KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.2
Objectives: Oxidative stress plays a central role in diabetes-induced complications. In the present study, the protevtive effect of Artemisia turanica (A. turanica) was evaluated against diabetes-induced liver oxidative stress and dysfunction. Methods: Fifty male Wistar rats were randomly divided into five groups: control, diabetic, diabetic + metformin, diabetic + A. turanica extract, and diabetic + A. turanica extract + metformin. Experimental diabetes was induced by a single-dose (55 mg/kg, intraperitoneally (ip)) injection of streptozotocin (STZ). Metformin (300 mg/kg) and A. turanica extract (70 mg/kg) were orally administrated three days after STZ injection for four weeks. The levels of malondialdehyde (MDA), total thiol content and superoxide dismutase (SOD) and catalase activities were measured in the liver tissue. Serum glucose concentration, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were also determined. Results: In the diabetic group, serum glucose concentration, serum AST and ALT activities and liver MDA level were significantly higher while tissue total thiol content as well as catalase and SOD activities were lower, compared to the control group. Serum glucose in diabetic rats treated with metformin + A. turanica extract showed a significant decrease compared with the diabetic group. In all the A. turanica extract and metformin treated groups, serum ALT, tissue MDA level, total thiol content and SOD activity significantly improved compared with the diabetic rats. However, treatment of the diabetic rats only with metformin could not significantly change the activities of catalase and AST compared with the diabetic group. Conclusion: These findings suggested that A. turanica extract had a therapeutic effect on liver dysfuncyion and oxidative stress induced by diabetes, that may be probably due to its antioxidant and antiinflammatory effects.