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김동찬,김호겸,민창기,김태현,김용욱 경희대학교 디자인연구원 2003 예술· 디자인학연구 Vol.6 No.1
The purpose of this study is to design a basic draft of a monumental inscription with a poem of a peace for stirring up a peaceful mind. The inscription is expected to be a place for arousing a peaceful mind to visitors. Moreover, this place can be a place for culture and rest, which uplifts the image and phase of Kyunghee University to both.
Kim, Min Keun,Kang, Tae Ho,Kim, Sung Kyum,Jeong, Yu Seok,Yun, Han Dae,Kim, Hoon The Korean Society for Applied Biological Chemistr 2012 Applied Biological Chemistry (Appl Biol Chem) Vol.55 No.6
The rsmA gene was cloned from soft-rot bacterium Pectobacterium carotovorum subsp. carotovorum LY34 (Pcc LY34), and its role in pathogenicity was investigated by marker exchange mutagenesis. From a cosmid library of Pcc LY34 genomic DNA, a positive clone carrying the rsmA gene was selected, and the gene was cloned by polymerase chain reaction (PCR) amplification. The gene is 186 bp in size and encodes a protein of 62 amino acids with a predicted molecular mass of 6,839 Da. The calculated pI of the RsmA is 8.16. The phylogenetic tree showed that the RsmA of Pcc LY34 appeared genetically identical to the CsrA of Pectobacterium atrosepticum SCRI1043 (100% identity) and similar to the CsrA of Yersinia pestis KIM10+(98.3%). The gene was disrupted by the $Km^r$ gene, and the cells became mutated (i.e., $RsmA^-$ mutant). The pathogenicity test revealed that the disease rating of the $RsmA^-$ mutant only differed slightly from that of the wild type on a slice of potato tuber and a Chinese cabbage stalk. These results suggest that RsmA is not an essential factor for the pathogenicity of Pcc LY34 and that the rsmA gene of Pcc LY34 is not completely derepressed in the $RsmA^-$ mutant for virulence-related genes, contrary to the results of Erwinia carotovora subsp. carotovora $RsmA^-$ mutant, which proved hypervirulent for celery petioles. These results showed that the microenvironmental conditions of the host and/or strain of pathogen are important for the coordination of virulence gene expression.
Kim, Jee Hung,Park, Hyung Soon,Heo, Su Jin,Kim, Sang Kyum,Han, Jung Woo,Shin, Kyoo-Ho,Kim, Seung Hyun,Hur, Hyuk,Kim, Kyung Sik,Choi, Young Deuk,Kim, Sunghoon,Lee, Young Han,Suh, Jin-Suck,Ahn, Joong-Ba S. Karger AG 2019 Oncology Vol.96 No.2
<P><B><I>Background:</I></B> We retrospectively investigated the treatment outcomes of second-line treatment with pazopanib or gemcitabine/docetaxel in patients with advanced soft tissue sarcoma (STS). <B><I>Methods:</I></B> Ninety-one patients who were treated with pazopanib or gemcitabine/docetaxel for advanced STS between 1995 and 2015 were analyzed. <B><I>Results:</I></B> Forty-six and 45 patients received pazopanib and gemcitabine/docetaxel, respectively. The median progression-free survival for the group treated with pazopanib was 4.5 months compared with 3.0 months for the gemcitabine/docetaxel group (<I>p</I> = 0.593). The median overall survival for the group treated with pazopanib was 12.6 months compared with 14.2 months for the gemcitabine/docetaxel group (<I>p</I> = 0.362). The overall response rates (ORRs) were 6.5 and 26.7% in the pazopanib and gemcitabine/docetaxel groups, respectively. The following parameters had ORRs favoring gemcitabine/docetaxel: age ≥50 years (31.6 vs. 2.9%, <I>p</I> = 0.006), histologic grade 1–2 (40.9 vs. 0%, <I>p</I> = 0.001), and poor first-line treatment response (23.3 vs. 3.0%, <I>p</I> = 0.022). Gemcitabine/docetaxel was associated with better ORRs for the following histologic subtypes: leiomyosarcoma (<I>p</I> = 0.624), malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma (<I>p</I> = 0.055), and angiosarcoma (<I>p</I> = 0.182). However, the ORR of synovial sarcoma favored pazopanib (<I>p</I> = 0.99). <B><I>Conclusions:</I></B> The efficacies of pazopanib and gemcitabine/docetaxel as second-line treatments after doxorubicin or ifosfamide failure differed among clinical and histologic subgroups and appeared to facilitate a more personalized treatment approach for advanced STS.</P>
Kim, Yeon-Ju,Kim, Myung Kyum,Bui, Thi Phuong Nam,Kim, Ho-Bin,Srinivasan, Sathiyaraj,Yang, Deok-Chun Society for General Microbiology 2010 International journal of systematic and evolutiona Vol.60 No.12
<P>Strain DCY37(T) was isolated from a soil sample of a ginseng field in the Republic of Korea and characterized in order to determine its taxonomic position. Cells were Gram-staining-positive, heterotrophic, strictly aerobic, non-motile short rods. 16S rRNA gene sequence analysis revealed that strain DCY37(T) belongs to the genus Microbacterium. According to 16S rRNA gene sequence analysis, it is closely related to Microbacterium aerolatum DSM 14217(T) (98.8?%), Microbacterium hydrocarbonoxydans DSM 16089(T) (98.5?%), Microbacterium natoriense JCM 12611(T) (98.5?%), Microbacterium foliorum (98.4?%) and Microbacterium phyllosphaerae (98.3?%). However, DNA-DNA hybridization studies showed reassociation values of less than 70?% between representative strains and DCY37(T). The DNA G+C content was 64.5 mol%. Strain DCY37(T) possessed chemotaxonomic markers that were consistent with classification in the genus Microbacterium, i.e. MK-12 and MK-13 as the major menaquinones and anteiso-C(15?:?0), anteiso-C(17?:?0) and iso-C(16?:?0) as the predominant cellular fatty acids. The major cell wall sugars were ribose, xylose and galactose. The diamino acid in cell-wall hydrolysates of strain DCY37(T) was ornithine and major cell-wall amino acids were alanine, glycine, d-glutamic acid and serine. The major polar lipids were glycolipid, phosphatidylglycerol, diphosphatidylglycerol and unknown aminolipids. Based on these data, DCY37(T) (=KCTC 19526(T) =JCM 15516(T)) should be classified as the type strain of a novel species of the genus Microbacterium, for which the name Microbacterium ginsengiterrae sp. nov. is proposed.</P>
Kim, Jong-Choon,Shin, Dong-Ho,Kim, Sung-Ho,Bae, Chun-Sik,Kim, Joon-Kyum,Cha, Shin-Woo,Han, Jung-Hee,Lee, Hyun-Sook,Chung, Moon-Koo Korean Society of ToxicologyKorea Environmental Mu 2004 Toxicological Research Vol.20 No.1
The present study was carried out to investigate the potential adverse effects of CKD-602 by a 5-day repeated intravenous dose in Sprague-Dawley rats. The test article, CKD-602, was administered intravenously to male and female rats at dose levels of 0.07, 0.22, 0.67, 2.0 and 6.0 mg/kg/day for 5 days consecutively. Mortalities, clinical findings, and body weight changes were monitored for the 14-day period after cessation of the administration. At the end of 14-day observation period, all animals were sacrificed and complete gross postmortem examinations were performed. There were 2 and 5 treatment related deaths in the 0.67 and 2.0 mg/kg/day dose groups of both genders, respectively. Treatment related clinical signs, including hair loss, skin paleness, decreased locomotor activity, emaciation, and changes in stool were observed in a dose-dependent manner from the third day after initiation of the injection. Decrease or suppression of body weight was also observed dose-dependently in males and females of the treated groups. Gross postmortem examinations revealed a dose-dependent increase in the incidence and severity of atrophy or hypertrophy and white membrane formation in the spleen, atrophy of the thymus, diffuse white spots and paleness of the liver, paleness of the lung, kidney and adrenal gland, and dark red discoloration and dark red contents in the alimentary tract. Based on these results, it was concluded that the 5-repeated intravenous injection of CKD-602 to male and female rats resulted in increased incidence of abnormal clinical signs and death, decreased or suppressed body weight, and increased incidence of abnormal gross findings. In the present experimental conditions, the $LD_{50}$ value was 2.07 (95% confidence limit not specified) mg/kg/day in both genders and the $LD_{10}$ value was 1.72 (95% confidence limit not specified) mg/kg/day in both genders.
Kim, Jeong Lan,Park, Joon Hyuk,Kim, Bong Jo,Kim, Moon Doo,Kim, Shin-Kyum,Chi, Yeon Kyung,Kim, Tae Hui,Moon, Seok Woo,Park, Moon Ho,Bae, Jae Nam,Woo, Jong Inn,Ryu, Seung-Ho,Yoon, Jong Chul,Lee, Nam-Jin Cambridge University Press 2012 INTERNATIONAL PSYCHOGERIATRICS - Vol.24 No.4
<B>ABSTRACT</B><P>Background: The influences of demographics, culture, language, and environmental changes on Mini-Mental State Examination (MMSE) scores are considerable.</P><P>Methods: Using a sample of 7452 healthy, community-dwelling elderly Koreans, aged 55 to 94 years, who participated in the four ongoing geriatric cohorts in Korea, we investigated demographic influences on MMSE scores and derived normative data for this population. Geropsychiatrists strictly excluded subjects with cognitive disorders according to the protocol of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K) Clinical Assessment Battery (CERAD-K-C).</P><P>Results: Education (standardized <I>β</I> = 0.463), age (standardized <I>β</I> = −0.303), and gender (standardized <I>β</I> = −0.057) had significant effects on MMSE scores (p < 0.001). The score of MMSE increase 0.379 point per 1-year education, decrease 0.188 per 1-year older, and decrease 0.491 in women compared to men. Education explained 30.4% of the scores’ total variance, which was much larger than the variances explained by age (8.4%) or gender (0.3%). Accordingly, we present normative data for the MMSE stratified by education (0, 1-3, 4-6, 7-9, 10-12, and ≥ 13 years), age (60-69, 70-79, and 80-89 years), and gender.</P><P>Conclusions: We provide contemporary education-, age-, and gender-stratified norms for the MMSE, derived from a large, community-dwelling elderly Korean population sample, which could be useful in evaluating individual MMSE scores.</P>
Kim, Yong An,Jin, Sun Woo,Oh, Suck Hoon,Lee, Gi Ho,Pham, Hoa Thi,Choi, Jae Ho,Chung, Young Chul,Lee, Wang Lok,Kim, Sang Kyum,Jeong, Hye Gwang Elsevier 2018 Food and chemical toxicology Vol.118 No.-
<P><B>Abstract</B></P> <P>Lower physical performance is an important risk factor in hypokinetic-related chronic disease, metabolic syndrome, and muscle atrophy. Our previous research demonstrated that <I>Platycodon grandiflorum</I>-derived saponin (PS) protects against eccentric exercise-induced muscle damage and mitochondrial function-related peroxisomal acyl-coenzme A oxidase (ACOX-1) and carnitine palmitoyltransferase (CPT-1) in high-fat diet-induced non-alcoholic steatohepatitis, and it inhibits osteoclast differentiation. However, the effects of PS on physical performance remain unknown. Therefore, we investigated whether PS enhances physical activity and skeletal muscle function. Supplementation with PS (2 mg/kg for 4 weeks) increased grip strength, wheel running repetition, and time to exhaustion in treadmill and swimming exercises. Marked increases in the synthesis of skeletal muscle proteins and muscle stem cell-related paired-box 7 (PAX7) were observed, and a decrease in the negative regulator myostatin was associated with enhanced muscle regeneration. Furthermore, PS induced expression of mitochondrial function proteins, including OXPHOS-III and -IV, <I>in vivo</I> and <I>in vitro</I>. These results suggest that PS enhances exercise function by ameliorating skeletal muscle protein synthesis and mitochondrial function.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PS enhance exercise function. </LI> <LI> PS increase protein synthesis in skeletal muscle. </LI> <LI> PS increase mitochondrial function in skeletal muscle. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>