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Optrode sensor for chemical and physical measurement
Hiroaki Aizawa,Hiroaki Ishizawa,Eiji Toba 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
This paper describes an optrode sensor for chemical and physical measurement and its application to industrial examinations. Among many king of optrode sensors, we have fabricated a temperature, oxygen and pH sensor and characteristics of which was experimentally investigated. Our experimental data shows the optrode sensor for chemical and physical measurement has singular capability as compared with a conventional sensor such as an electrode sensor.
Targeted siRNA therapy using cytoplasm-responsive nanocarriers and cell-penetrating peptides
Hiroaki Okada 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.7
Cell-penetrating peptides (CPPs) involved inthe uptake of large molecules such as proteins, nucleotidesand nanoparticles have potential as safe, non-viral carriersfor gene therapy. Several kinds of cytosol-sensitive genepolymercomplexes were investigated, including disulfidecrosslinked polyethylenimines, poly(amido amine)s, andpolypeptides. We synthesized an artificial CPP, CH2R4H2C(C, cysteine [Cys]; H, histidine [His]; R, arginine [Arg]). This CPP has two Cys residues for physically trappinggenes in micelles by disulfide linkage, and is conjugatedeither with stearic acid for enhancing transfection efficiencyby local administration, or with methoxy-poly(ethyleneglycol)-block-poly(e-caprolactone) for systemicadministration. Nucleotides were rigidly shielded in thenanomicelles, protected against nucleases in the blood, andspontaneously released into the reducing environment ofthe cytoplasm. In this review, the researches on the cytoplasm-responsive functional CPP nanocarriers for genetransfection into cells are reviewed and our trials aredescribed in detail.
Three Basic Theorems in Numerical Analysis in Control Engineering Course and Their Application
Hiroaki Mukaidani,Tadashi Shima 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.5
Control system design packages like MATLAB, SICLAB, OCTAVE, etc. have become essential components of both undergraduate and graduate courses in the field of systems and controls. In particular, the most important subject related to control system design in the undergraduate course is the analysis of a nonlinear equation that is based on iterative methods. In this paper, applications of three basic theorems, –implicit function theorem, Newton-Kantorovich theorem, and fixed point theorem– are proposed to be taught in the numerical analysis in the control engineering course. In order to demonstrate the usefulness of these theorems, several important features are discussed. Furthermore, a practice exercise based on the practical control problem is discussed for proving the useful subject of the numerical analysis in the control engineering course in the graduate level.
Hiroaki Wakayama,Hirotaka Yonekura 한국고분자학회 2017 Macromolecular Research Vol.25 No.3
Structural control of polymer nanocomposites is important for their applications in organic semiconductors, lithographic nanopatterning, separation membranes, and nanofabrication templates. However, manufacturing nanocomposite materials with novel structures in a highly efficient yet precise manner remains a great challenge. To create nanocomposite structures, we combined self-assembly processing of block copolymer (BCP)-metal complex nanocomposites with an applied magnetic field. Here, we describe in detail the mechanism of magnetic alignment of block copolymers doped with metal complexes; specifically, we investigated the effect of the applied magnetic field on the phase behavior of the assembled block copolymer-metal complex nanocomposites with various molecular weights and with different molecular structures. We show that our combination of self-assembly processing and application of a magnetic field yielded lamellar structures of alternating multilayers with different layer thicknesses. This self-assembled structure is not included in phase diagrams of BCPs. The influence of the block copolymers’ molecular structures on the nanocomposites’ phase transformation behavior is also discussed. Our results provide a route to manufacturing nanocomposite materials in a highly efficient yet precise manner, which could lead to improvement in the material properties of nanocomposites.