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지상환,Ji-Hyun Lee,Joo-Youn Cho,Hwa Suk Kim,Young-Eun Jang,EUN-HEE KIM,Jin Tae Kim,Heesoo Kim 대한의학회 2020 Journal of Korean medical science Vol.35 No.11
Background: Previously, a linked pharmacokinetic-pharmacodynamic model (the Kim model) of propofol with concurrent infusion of remifentanil was developed for children aged 2–12 years. There are few options for pharmacokinetic-pharmacodynamic model of propofol for children under two years old. We performed an external validation of the Kim model for children under two years old to evaluate whether the model is applicable to this age group. Methods: Twenty-four children were enrolled. After routine anesthetic induction, a continuous infusion of 2% propofol and remifentanil was commenced using the Kim model. The target effect-site concentration of propofol was set as 2, 3, 4, and 5 μg/mL, followed by arterial blood sampling after 10 min of each equilibrium. Population estimates of four parameters—pooled bias, inaccuracy, divergence, and wobble—were used to evaluate the performance of the Kim model. Results: A total of 95 plasma concentrations were used for evaluation of the Kim model. The population estimate (95% confidence interval) of bias was −0.96% (−8.45%, 6.54%) and that of inaccuracy was 21.0% (15.0%–27.0%) for the plasma concentration of propofol. Conclusion: The pooled bias and inaccuracy of the pharmacokinetic predictions are clinically acceptable. Therefore, our external validation of the Kim model indicated that the model can be applicable to target-controlled infusion of propofol in children younger than 2 years, with the recommended use of actual bispectral index monitoring in clinical settings that remifentanil is present.
Kim, HeeSoo,Choi, Joon-Il,Kim, Bo Hyun,Youn, Seo Yeon,Kim, Hokun,Kim, Dong Hwan,Rha, Sung Eun Korean Society of Magnetic Resonance in Medicine 2021 Investigative Magnetic Resonance Imaging Vol.25 No.3
Purpose: We evaluated the diagnostic performance of LI-RADS version 2018 using gadoxetic acid enhanced MRI for recurrent but untreated HCC in patients with prior history of HCC. Materials and Methods: We enrolled 50 consecutive patients who 1) prior history of treatment of HCC, 2) underwent liver surgery for radiological/clinical diagnosis of new HCC between 2013 to 2018, 3) had gadoxetic acid enhanced MRI within one month before surgery, and 4) did not have more than five HCCs or infiltrative tumors only. Two radiologists reviewed MRI and determined the presence of LR3, LR4 and LR5 observations except previously treated tumors based on LI-RADS version 2018 in consensus. We sub-classified LR4 into LR4m (LR4 with major features only) and LR4u (LR4 upgraded from LR3 by ancillary features). LR4u were further sub-classified into LR4ua (with arterial phase hyperenhancement) and LR4un (without arterial phase hyperenhancement). Results: PPV for LR5, LR4 and LR3 observations for recurrent HCC were 100%, 61.5% and 25.0%, respectively. 100% (3/3) of LR4m were HCC. However, PPV of LR4u was 56.5%. PPV of LR4ua and LR4un were 73.3% and 25.0%, respectively. Sensitivity of LR5 and LR5+LR4 observations as a diagnostic threshold were 32.1% and 89.3%, respectively. Sensitivity for LR5+LR4m+LR4ua observations for diagnosis of HCC were 83.7% and significantly superior to that of LR5 without significant deterioration of specificity (75.0%). Conclusion: In patients with prior history of HCC, LR4 observations by major features or with APHE may be regarded as recurrent HCCs given high sensitivity and comparable specificity/PPV to LR5 observations.
Kim, Jin Chul,Jung, Jungwoon,Rho, Yecheol,Kim, Mihee,Kwon, Wonsang,Kim, Heesoo,Kim, Ik Jung,Kim, Jung Ran,Ree, Moonhor American Chemical Society 2011 Biomacromolecules Vol.12 No.7
<P>Two new DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)ethylene] (PECH-AS). These polymers were found to be thermally stable up to 220 °C and could be applied easily by conventional coating processes to produce good quality films. Interestingly, both brush polymers formed molecular multibilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. However, the high hydrophilicity and good water sorption characteristics of the PECH-AS film suggest that this brush polymer is better suited to applications requiring good biocompatibility and reduced chance of bacterial infection compared with the PECH-AP film.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-7/bm200572t/production/images/medium/bm-2011-00572t_0012.gif'></P>
Kim, Gahee,Park, Samdae,Jung, Jungwoon,Heo, Kyuyoung,Yoon, Jinhwan,Kim, Heesoo,Kim, Ik Jung,Kim, Jung Ran,Lee, Jong Im,Ree, Moonhor WILEY-VCH Verlag 2009 Advanced functional materials Vol.19 No.10
<P>New brush polymers with various numbers of bristle ends incorporating phosphorylcholine (PC) moieties are synthesized. The polymers are thermally stable up to 175 °C and form good-quality films with conventional spin-, roll-, and dip-coating, and subsequent drying processes. Interestingly, all these brush polymers, as a PC-containing polymer, demonstrate a stable molecular multi-bilayer structure in thin films that arise due to the efficient self-assembly of the bristles for temperatures <55 °C and PC-rich surfaces, and therefore successfully mimic natural cell-membrane surfaces. These brush-polymer films exhibit excellent water wettability and water sorption whilst retaining the remarkable molecular multi-bilayer structure, and thus have hydrophilic surfaces. These novel multi-bilayer structured films repel fibrinogen molecules and platelets from their surfaces but also have bactericidal effects on bacteria. Moreover, the brush-polymer films are found to provide comfortable surface environments for the successful anchoring and growth of HEp-2 cells, and to exhibit excellent biocompatibility in mice. These newly developed brush polymers are suitable for use in biomedical applications including medical devices and biosensors that require biocompatibility and the reduced possibility of post-operative infection.</P> <B>Graphic Abstract</B> <P>New brush polymers with various numbers of bristle ends incorporating phosphorylcholine (PC) moieties are synthesized. The new PC-containing brush polymers (see image) form a stable molecular multi-bilayer structure in thin films and successfully mimic natural cell membrane surfaces. The hydrophilic surface of the films repels fibrinogen and platelets and exhibit bactericidal effects. <img src='wiley_img/1616301X-2009-19-10-ADFM200801680-content.gif' alt='wiley_img/1616301X-2009-19-10-ADFM200801680-content'> </P>
김희수(Heesoo Kim),배용채(Yongchae Bae),김연환(Yeonwhan Kim),이현(Hyun Lee),김성휘(Sunghwi Kim) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4
The steady stress, modal analysis for the damaged blade was carried out to evaluate the integrity of LP 4<br/> blade row. As a result, 4 dangerous modes for LP blade row were found in the interference diagram and it<br/> was confirmed that the nozzle passing frequency has nothing to do with the blade failure. And then the<br/> dynamic stress are analysed for the 4 dangerous modes. There are some points far out of maximum allowable<br/> stress in the cover and tenon. Therefore the blade is not safe according to the Goodman judgement. So the<br/> manufacturer have modified the design of cover and tenon. Until now, the power plant is being operated<br/> without special problems.
pH-Dependent Structures of Ferritin and Apoferritin in Solution: Disassembly and Reassembly
Kim, Mihee,Rho, Yecheol,Jin, Kyeong Sik,Ahn, Byungcheol,Jung, Sungmin,Kim, Heesoo,Ree, Moonhor American Chemical Society 2011 Biomacromolecules Vol.12 No.5
<P>The pH-dependent structures of the ferritin shell (apoferritin, 24-mer) and the ferrihydrite core, under physiological conditions that permit enzymatic activity, were investigated by synchrotron small-angle X-ray scattering (SAXS). The solution structure of apoferritin was found to be nearly identical to the crystal structure. The shell thickness and hollow core volumes were estimated. The intact hollow spherical apoferritin was stable over a wide pH range, 3.40−10.0, and the ferrihydrite core was stable over the pH range 2.10−10.0. The apoferritin subunits underwent aggregation below pH 0.80, whereas the ferrihydrite cores aggregated below pH 2.10 as a result of the disassembly of the ferritin shell under the strongly acidic conditions. As the pH decreased from 3.40 to 0.80, apoferritin underwent stepwise disassembly by first forming a hollow sphere with two holes, then a headset-shaped structure, and, finally, rodlike oligomers. As the pH was increased from pH 1.96, the disassembled rodlike oligomers recovered only to the headset-shaped structure, and the disassembled headset-shaped intermediates recovered only to the hollow spherical structure with two hole defects. The apoferritin hole defects that formed during the disassembly process did not heal as the pH was increased to neutral or slightly basic conditions. The pH-induced apoferritin disassembly and reassembly processes were not fully reversible, although they were pseudoreversible over a limited pH range, between 10.0 and 2.66.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bomaf6/2011/bomaf6.2011.12.issue-5/bm200026v/production/images/medium/bm-2011-00026v_0010.gif'></P>