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      • CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

        Hashim, Natasha,Jamalludin, Zulaikha,Ung, Ngie Min,Ho, Gwo Fuang,Malik, Rozita Abdul,Ee Phua, Vincent Chee Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

        Background: CT based brachytherapy allows 3-dimensional (3D) assessment of organs at risk (OAR) doses with dose volume histograms (DVHs). The purpose of this study was to compare computed tomography (CT) based volumetric calculations and International Commission on Radiation Units and Measurements (ICRU) reference-point estimates of radiation doses to the bladder and rectum in patients with carcinoma of the cervix treated with high-dose-rate (HDR) intracavitary brachytherapy (ICBT). Materials and Methods: Between March 2011 and May 2012, 20 patients were treated with 55 fractions of brachytherapy using tandem and ovoids and underwent post-implant CT scans. The external beam radiotherapy (EBRT) dose was 48.6Gy in 27 fractions. HDR brachytherapy was delivered to a dose of 21 Gy in three fractions. The ICRU bladder and rectum point doses along with 4 additional rectal points were recorded. The maximum dose ($D_{Max}$) to rectum was the highest recorded dose at one of these five points. Using the HDRplus 2.6 brachyhtherapy treatment planning system, the bladder and rectum were retrospectively contoured on the 55 CT datasets. The DVHs for rectum and bladder were calculated and the minimum doses to the highest irradiated 2cc area of rectum and bladder were recorded ($D_{2cc}$) for all individual fractions. The mean $D_{2cc}$ of rectum was compared to the means of ICRU rectal point and rectal $D_{Max}$ using the Student's t-test. The mean $D_{2cc}$ of bladder was compared with the mean ICRU bladder point using the same statistical test. The total dose, combining EBRT and HDR brachytherapy, were biologically normalized to the conventional 2 Gy/fraction using the linear-quadratic model. (${\alpha}/{\beta}$ value of 10 Gy for target, 3 Gy for organs at risk). Results: The total prescribed dose was $77.5Gy{\alpha}/{\beta}10$. The mean dose to the rectum was $4.58{\pm}1.22Gy$ for $D_{2cc}$, $3.76{\pm}0.65Gy$ at $D_{ICRU}$ and $4.75{\pm}1.01Gy$ at $D_{Max}$. The mean rectal $D_{2cc}$ dose differed significantly from the mean dose calculated at the ICRU reference point (p<0.005); the mean difference was 0.82 Gy (0.48-1.19Gy). The mean EQD2 was $68.52{\pm}7.24Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$, $61.71{\pm}2.77Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$ and $69.24{\pm}6.02Gy_{{\alpha}/{\beta}3}$ at $D_{Max}$. The mean ratio of $D_{2cc}$ rectum to $D_{ICRU}$ rectum was 1.25 and the mean ratio of $D_{2cc}$ rectum to $D_{Max}$ rectum was 0.98 for all individual fractions. The mean dose to the bladder was $6.00{\pm}1.90Gy$ for $D_{2cc}$ and $5.10{\pm}2.03Gy$ at $D_{ICRU}$. However, the mean $D_{2cc}$ dose did not differ significantly from the mean dose calculated at the ICRU reference point (p=0.307); the mean difference was 0.90 Gy (0.49-1.25Gy). The mean EQD2 was $81.85{\pm}13.03Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$ and $74.11{\pm}19.39Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$. The mean ratio of $D_{2cc}$ bladder to $D_{ICRU}$ bladder was 1.24. In the majority of applications, the maximum dose point was not the ICRU point. On average, the rectum received 77% and bladder received 92% of the prescribed dose. Conclusions: OARs doses assessed by DVH criteria were higher than ICRU point doses. Our data suggest that the estimated dose to the ICRU bladder point may be a reasonable surrogate for the $D_{2cc}$ and rectal $D_{Max}$ for $D_{2cc}$. However, the dose to the ICRU rectal point does not appear to be a reasonable surrogate for the $D_{2cc}$.

      • KCI등재

        Design and Experimental Verification of a 3-DOF Spherical Electromagnetic Brake for Haptic Interface

        Hashim Iqbal,Byung-Ju Yi 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.5

        Electromagnetic brake is an efficient device that provides damping to stop the undesired motion of the manipulator. A spherical design of electromagnetic brake is presented with a simple and compact alternative for haptic application. The model exploits coulomb friction to generate fully controllable braking in 3-DOF rotational motion. For miniaturized applications, the design can provide significant torques while rejecting unwanted heat generated in the actuator. In this paper, the analytical models of magnetic force and friction moment are derived, and the brake design is optimized for maximizing the force to input power ratio. The spherical electromagnetic brake is applied for haptic interface and its performance is justified by the experimental results in the virtual reality Environment.

      • SCISCIESCOPUS
      • Cost modelling of heritage buildings in Malaysia. Issues and challenges

        Hashim, Suliahti,Kaliwon, Julaida,Rozi Nur Rabiatul Adawiah 한국생태환경건축학회 2021 한국생태환경건축학회 학술발표대회 논문집 Vol.21 No.2

        Project cost estimates that are accurate and trustworthy are critical in determining whether to proceed with the construction activities. As it involves requests for proposals, cost estimating, contract negotiations, scheduling and levelling, and other activities, cost estimates are utilised to get the funds required. Depending on time constraints and the availability of cost data, cost estimators employ a variety of estimation methods and approaches. Cost estimator experience is required, as well as consideration of the identified potential risks that must be updated. This will have an impact on the accuracy of cost estimations. The heritage building is one of the national real estates and its conservation measures often receive attention especially with respect to financial allocations. This study was made to highlight the challenges in producing cost modeling conservation work and two historical buildings have been selected as case studies. Observation techniques, interviews, and document analysis were used to obtain the data. Findings show that it is critical to creating an accurate, thorough, and reproducible cost estimate for cost modelling for conservation works. Therefore, it is hoped that this study can be used as a reference for problem-solving that occurs as well as references for relevant research in the future.

      • SCISCIESCOPUS
      • A new approach for solving global optimization and engineering problems based on modified sea horse optimizer

        Hashim Fatma A,Mostafa Reham R,Khurma Ruba Abu,Qaddoura Raneem,Castillo Pedro A 한국CDE학회 2024 Journal of computational design and engineering Vol.11 No.1

        Sea horse optimizer (SHO) is a noteworthy metaheuristic algorithm that emulates various intelligent behaviors exhibited by sea horses, encompassing feeding patterns, male reproductive strategies, and intricate movement patterns. To mimic the nuanced locomotion of sea horses, SHO integrates the logarithmic helical equation and Levy flight, effectively incorporating both random movements with substantial step sizes and refined local exploitation. Additionally, the utilization of Brownian motion facilitates a more comprehensive exploration of the search space. This study introduces a robust and high-performance variant of the SHO algorithm named modified sea horse optimizer (mSHO). The enhancement primarily focuses on bolstering SHO’s exploitation capabilities by replacing its original method with an innovative local search strategy encompassing three distinct steps: a neighborhood-based local search, a global non-neighbor-based search, and a method involving circumnavigation of the existing search region. These techniques improve mSHO algorithm’s search capabilities, allowing it to navigate the search space and converge toward optimal solutions efficiently. To evaluate the efficacy of the mSHO algorithm, comprehensive assessments are conducted across both the CEC2020 benchmark functions and nine distinct engineering problems. A meticulous comparison is drawn against nine metaheuristic algorithms to validate the achieved outcomes. Statistical tests, including Wilcoxon’s rank-sum and Friedman’s tests, are aptly applied to discern noteworthy differences among the compared algorithms. Empirical findings consistently underscore the exceptional performance of mSHO across diverse benchmark functions, reinforcing its prowess in solving complex optimization problems. Furthermore, the robustness of mSHO endures even as the dimensions of optimization challenges expand, signifying its unwavering efficacy in navigating complex search spaces. The comprehensive results distinctly establish the supremacy and efficiency of the mSHO method as an exemplary tool for tackling an array of optimization quandaries. The results show that the proposed mSHO algorithm has a total rank of 1 for CEC2020 test functions. In contrast, the mSHO achieved the best value for the engineering problems, recording a value of 0.012 665, 2993.634, 0.01 266, 1.724 967, 263.8915, 0.032 255, 58 507.14, 1.339 956, and 0.23 524 for the pressure vessel design, speed reducer design, tension/compression spring, welded beam design, three-bar truss engineering design, industrial refrigeration system, multi-product batch plant, cantilever beam problem, and multiple disc clutch brake problems, respectively. Source codes of mSHO are publicly available at https://www.mathworks.com/matlabcentral/fileexchange/135882-improved-sea-horse-algorithm.

      • KCI등재
      • SSCISCOPUSKCI등재

        Career, Family and Community

        Hashim, Habsah,Omar, Roziah 숙명여자대학교 아시아여성연구소 2004 Asian Women Vol.19 No.-

        This paper aims to analyze the dilemma faced by professional and semi-professional Malay women in terms of various roles, namely the reproductive role (family), the productive role (career), and the community-organizing role. The reproductive role, which is seen as the typical women's job, is analyzed in terms of fertility, childcare and domestic duties. The productive role, which is highly related to education level, is looked at in terms of perception and choices and also career development. The community organizing role, an often neglected aspect, is measured by involvement in local community organizations and associations. The study found that children are regarded as blessings in the Malay households and did not hinder the mothers to participate in labor force. However, being dual-earner households, work-family conflicts, childcare arrangements and domestic chores do create tensions and dilemmas. The women, though most are educated, seem to make sacrifices and forego their own personal attainment in order to cope with the dual-role. Participation in community work in general, is always the least priority. From the study, it is found that more family-friendly policies are urgently needed.

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