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- 저자 : Han Kiwon (검색결과 69 건)
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Han, Kiwon,Seo, Hwi Won,Shin, Jeoung Hwa,Oh, Yeonsu,Kang, Ikjae,Park, Changhoon,Chae, Chanhee American Society for Microbiology 2011 CLINICAL AND VACCINE IMMUNOLOGY Vol.18 No.10
<B>ABSTRACT</B><P>The objective of the present study was to compare the effects of the modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine (Ingelvac PRRS MLV; Boehringer Ingelheim Animal Health, St. Joseph, MO) on European and North American PRRSV shedding in the semen of experimentally infected boars. The boars were randomly divided into six groups. Vaccinated boars shed the North American PRRSV at the rate of 10<SUP>0.1</SUP>to 10<SUP>1.0</SUP>viral genome copies per ml and 3.63 to 10<SUP>1.1</SUP>50% tissue culture infective doses (TCID50)/ml, respectively, in semen, whereas nonvaccinated boars shed the North American PRRSV at the rate of 10<SUP>0.2</SUP>to 10<SUP>4.7</SUP>viral genome copies per ml and 1.14 to 10<SUP>3.07</SUP>TCID50/ml, respectively, in semen. Vaccinated boars shed the European PRRSV at the rate of 10<SUP>0.1</SUP>to 10<SUP>4.57</SUP>viral genome copies per ml and 1.66 to 10<SUP>3.10</SUP>TCID50/ml, respectively, in semen, whereas nonvaccinated boars shed the European PRRSV at the rate of 10<SUP>0.3</SUP>to 10<SUP>5.14</SUP>viral genome copies per ml and 1.69 to 10<SUP>3.17</SUP>TCID50/ml, respectively, in semen. The number of genomic copies of the European PRRSV in semen samples was not significantly different between vaccinated and nonvaccinated challenged European PRRSV boars. The present study demonstrated that boar vaccination using commercial modified live PRRSV vaccine was able to decrease subsequent shedding of North American PRRSV in semen after challenge but was unable to decrease shedding of European PRRSV in semen after challenge.</P>
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A Collaborative Study to Establish the Second Korean National Reference Standard for Snake Venom
Han, Kiwon,Jung, Kikyung,Oh, Hokyung,Song, Hojin,Park, Sangmi,Kim, Ji-Hye,Min, Garam,Lee, Byung-Hwa,Nam, Hyun-sik,Kim, Yang Jin,Ato, Manabu,Jeong, Jayoung,Ahn, Chiyoung Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.3
In 2015, a candidate for the second national reference standard (NRS) of Gloydius snake venom was produced to replace the first NRS of Gloydius snake venom. In the present study, the potencies of the candidate were determined by a collaborative study, and the qualification of the candidate was estimated. The potencies of the candidate were determined by measuring the murine lethal titers and lapine hemorrhagic titers of venom against the regional working reference standard (RWRS) for antivenom using the methods described in the previous report for the first NRS of Gloydius snake venom. Three Korean facilities contributed data from a total of 30 independent assays. Subsequently, two foreign national control research laboratories contributed to this collaborative study. The results were calculated using the Reed-Muench method for lethality and determined using a mixed-effects model for hemorrhage. The general common potencies of the lethal and hemorrhagic titers were obtained from the results of the 30 tests performed at three Korean facilities. The results are expressed in micrograms for 1 test dose (TD) with a 95% confidence interval as follows: a lethal titer of $90.13{\mu}g/TD$ (95% confidence interval = $87.39{\sim}92.86{\mu}g$) and a hemorrhagic titer of $10.80{\mu}g/TD$ (95% confidence interval = $10.46{\sim}11.14{\mu}g$). In addition, the candidate preparation showed good quality evaluation according to the results of the quality estimation of the candidate and is judged to be suitable to serve as the Korean NRS for snake venom. In conclusion, the second NRS of Gloydius snake venom was established in this study and will be used for national quality control, including a national lot release test of Korean antivenom products.
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Han Kiwon,Song Hojin,Choi Chan Woong,Park Sangmi,Kang Yong Seok,Jung Kikyung,Lee Byung-Hwa,Takahashi Yoshimasa,Matsumura Takayuki,Yamamoto Akihiko,Kim Yang Jin,Jee Seung-wan,Kim Jaeok 한국독성학회 2020 Toxicological Research Vol.36 No.4
In 2017, the second national reference standard (NRS) for Gloydius snake venom was established to replace the first NRS for Gloydius snake venom. In connection with the second venom NRS, a candidate for the first NRS for Gloydius snake antivenom was produced in 2017. In this study, the qualification of the candidate was estimated and the potency was determined by a collaborative study. The potency (anti-lethal titer and anti-hemorrhagic titer) of the candidate was determined by measuring the capability of the antivenom to neutralize the lethal and hemorrhagic effects of the second NRS for Gloydius snake venom, which was calibrated against the regional reference standard for Gloydius snake antivenom established in 2006. Two Korean facilities contributed data from 20 independent assays. Subsequently, one foreign national control research laboratories participated in this collaborative study. The general common potency of the anti-lethal and anti-hemorrhagic titers was obtained from the results of a total of 25 tests performed at three facilities. According to the results of the present study, the candidate preparation showed good quality and is judged to be suitable to serve as the first NRS for Gloydius snake antivenom with the following potency: an anti-lethal titer of 3100 unit (U) (95% confidence interval 2991–3276 U) and anti-hemorrhagic titer of 3000 U (95% confidence interval 2849–3159 U). In conclusion, the first NRS for Gloydius snake antivenom was established in this study. This reference standard will be used routinely for quality control of a snake antivenom product by manufacturer in Korea, which also can be used for national quality control, including a national lotrelease test of the snake antivenom product.
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Han-Yeong Jeong,Jun-Young Chang,Kyu Sun Yum,Jeong-Ho Hong,Jin-Heon Jeong,Min-Ju Yeo,Hee-Joon Bae,Moon-Ku Han,Kiwon Lee 대한뇌졸중학회 2016 Journal of stroke Vol.18 No.3
Background and Purpose The use of decompressive hemicraniectomy (DHC) for the treatment of malignant cerebral edema can decrease mortality rates. However, this benefit is not sufficient to justify its use in elderly patients. We investigated the effects of therapeutic hypothermia (TH) on safety, feasibility, and functional outcomes in elderly patients with malignant middle cerebral artery (MCA) infarcts. Methods Elderly patients 60 years of age and older with infarcts affecting more than two-thirds of the MCA territory were included. Patients who could not receive DHC were treated with TH. Hypothermia was started within 72 hours of symptom onset and was maintained for a minimum of 72 hours with a target temperature of 33°C. Modified Rankin Scale (mRS) scores at 3 months following treatment and complications of TH were used as functional outcomes. Results Eleven patients with a median age of 76 years and a median National Institutes of Health Stroke Scale score of 18 were treated with TH. The median time from symptom onset to initiation of TH was 30.3±23.0 hours and TH was maintained for a median of 76.7±57.1 hours. Shivering (100%) and electrolyte imbalance (82%) were frequent complications. Two patients died (18%). The mean mRS score 3 months following treatment was 4.9±0.8. Conclusions Our results suggest that extended use of hypothermia is safe and feasible for elderly patients with large hemispheric infarctions. Hypothermia may be considered as a therapeutic alternative to DHC in elderly individuals. Further studies are required to validate our findings.
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Han, Kiwon,Seo, Hwi Won,Park, Changhoon,Chae, Chanhee BioMed Central 2014 VETERINARY RESEARCH Vol.45 No.-
<P>The objective of the present study was to determine the effects of the commercially available type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV)-based modified live vaccine against type 1 and type 2 PRRSV challenge in pregnant sows. Half of the sows in the study were vaccinated with a type 2 PRRSV-based vaccine 4 weeks prior to artificial insemination while the other half remained non-vaccinated. Sows were then challenged intranasally with type 1 or type 2 PRRSV at 93 days of gestation. The sows which received the type 2 PRRSV-based vaccine followed by type 2 PRRSV challenge had significantly higher neutralizing antibody titers against type 2 PRRSV than they did against type 1 PRRSV. These same sows had higher frequencies of IFN-γ-secreting cells when stimulated with type 2 PRRSV compared to those stimulated with type 1 PRRSV. Subsequent virological evaluation demonstrated that the type 2 PRRSV-based vaccine reduced the type 2 PRRSV load but not the type 1 PRRSV load present in the blood of the sows. Additionally, vaccination of pregnant sows with the type 2 PRRSV-based vaccine effectively reduced the level of type 2 PRRSV nucleic acids observed in fetal tissues from type 2 PRRSV-challenged sows but did not reduce the level of type 1 PRRSV nucleic acid observed in fetal tissues from type 1 PRRSV-challenged sows. This study demonstrates that the vaccination of pregnant sows with the type 2 PRRSV-based vaccine protects against type 2 PRRSV challenge but does not protect against type 1 PRRSV challenge.</P>
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A Collaborative Study to Establish the Second Korean National Reference Standard for Snake Venom
Kiwon Han,Kikyung Jung,Hokyung Oh,Hojin Song,Sangmi Park,Ji-Hye Kim,Garam Min,Byung-Hwa Lee,Hyun-sik Nam,Yang Jin Kim,Manabu Ato,Jayoung Jeong,Chiyoung Ahn 한국독성학회 2018 Toxicological Research Vol.34 No.3
In 2015, a candidate for the second national reference standard (NRS) of Gloydius snake venom was produced to replace the first NRS of Gloydius snake venom. In the present study, the potencies of the candidate were determined by a collaborative study, and the qualification of the candidate was estimated. The potencies of the candidate were determined by measuring the murine lethal titers and lapine hemorrhagic titers of venom against the regional working reference standard (RWRS) for antivenom using the methods described in the previous report for the first NRS of Gloydius snake venom. Three Korean facilities contributed data from a total of 30 independent assays. Subsequently, two foreign national control research laboratories contributed to this collaborative study. The results were calculated using the Reed-Muench method for lethality and determined using a mixed-effects model for hemorrhage. The general common potencies of the lethal and hemorrhagic titers were obtained from the results of the 30 tests performed at three Korean facilities. The results are expressed in micrograms for 1 test dose (TD) with a 95% confidence interval as follows: a lethal titer of 90.13 ㎍/TD (95% confidence interval = 87.39~92.86 ㎍) and a hemorrhagic titer of 10.80 ㎍/TD (95% confidence interval = 10.46~11.14 ㎍). In addition, the candidate preparation showed good quality evaluation according to the results of the quality estimation of the candidate and is judged to be suitable to serve as the Korean NRS for snake venom. In conclusion, the second NRS of Gloydius snake venom was established in this study and will be used for national quality control, including a national lot release test of Korean antivenom products.
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한기원(Kiwon Han),류완식(Wansik Ryu),장인규(In-Gyu Jang),전재욱(Jaewook Jeon),김현수(Hyunsoo Kim),황성호(Sungho Hwang) 한국자동차공학회 2006 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The continuously variable transmission (CVT), to implement speed ratio infinitely in the fixed range, has the characteristic of low fuel consumption and low exhaust gas due to operating the vehicle in a high efficiency range without concerning between engine speed and vehicle speed. The speed ratio of belt type CVT is controlled by adjusting line pressure. The line pressure control prevents slip between the pulley and the belt by conserving optimal line pressure, which is implemented by controlling the thrust force of actuators of both the drive-shaft and the driven-shaft. The one of the line pressure control methods, mechanical-hydraulic control is usually adopting VDT's control method, in which the secondary solenoid valve has two functions both a regulator and a line pressure controller. However, this control method could not show the high performance of CVT with optimal driving capability because of the limitation of simple control algorithm, and it could not gain market share sufficiently in spite of the advantage of CVT with low fuel consumption. On the other hand, the electro-hydraulic control method gives the enhancement of power performance and low fuel consumption by implementing various driving mode using the proportional control or PWM control. The key of CVT technique is to develop a control algorithm of the electro-hydraulic solenoid valve in order to implement the speed ratio efficiently. In this paper, the line pressure control algorithm is proposed and the speed control characteristic is validated using metal belt type CVT test rig and the embedded ECU platform.
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임베디드 시스템을 이용한 AMT용 자동 클러치의 제어 성능 평가
한기원(Kiwon Han),류완식(Wansik Ryu),이상원(Sangwon Lee),전재욱(Jaewook Jeon),황성호(Sungho Hwang) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_2
Drivers are becoming more fatigued and uncomfortable as traffic densities increase, this can lead to slower reaction time. They then face the danger of traffic accidents due to an inability to cope with frequent shifting. To reduce this risk some drivers prefer automatic transmissions to manual transmissions. However, the automatic transmission comes with both higher fuel consumptions and costs. For these reasons, the attention given to the automated manual transmission (AMT) is increasing, that has the advantages such as high efficiency, low cost and easy manufacturing. And the function and performance of an electronic control unit(ECU) for automobiles is improved continuously and rapidly with the growing electronics technology. The ECU is the representative embedded system of automobiles which has to satisfy high performance and reliability on the constrains of size and cost. In this paper, the embedded system platform for automobiles is developed on the basis of MPC565, and a test rig is developed to perform the bask function test for the automatic dutch actuation. The developed embedded system and dutch control algorithm are validated by the experimental results performed on the test rig.
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