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Artificial Muscles from Fishing Line and Sewing Thread
Haines, Carter S.,Lima, Má,rcio D.,Li, Na,Spinks, Geoffrey M.,Foroughi, Javad,Madden, John D. W.,Kim, Shi Hyeong,Fang, Shaoli,Jung de Andrade, Mô,nica,Gö,ktepe, Fatma,Gö,ktepe, &Oum American Association for the Advancement of Scienc 2014 Science Vol.343 No.6173
<P><B>Toward an Artificial Muscle</B></P><P>In designing materials for artificial muscles, the goals are to find those that will combine high strokes, high efficiency, long cycle life, low hysteresis, and low cost. Now, <B>Haines <I>et al.</I></B> (p. 868; see the Perspective by <B>Yuan and Poulin</B>) show that this is possible. Twisting high-strength, readily available polymer fibers, such as those used for fishing lines or sewing thread, to the point where they coil up, allowed construction of highly efficient actuators that could be triggered by a number of stimuli.</P>
Haines, Brian B.,Ryu, Chun Jeih,Chang, Sandy,Protopopov, Alexei,Luch, Andreas,Kang, Yun Hee,Draganov, Dobrin D.,Fragoso, Maria F.,Paik, Sang Gi,Hong, Hyo Jeong,DePinho, Ronald A.,Chen, Jianzhu Cell Press 2006 CANCER CELL Vol.9 No.2
<P><B>Summary</B></P><P>Mice deficient in the DNA damage sensor P53 display normal T cell development but eventually succumb to thymic lymphomas. Here, we show that inactivation of the TCR β gene enhancer (Eβ) results in a block of T cell development at stages where recombination-activating genes (RAG) are expressed. Introduction of the Eβ mutation into <I>p53<SUP>−/−</SUP></I> mice dramatically accelerates the onset of lethal thymic lymphomas that harbor RAG-dependent aberrant rearrangements, chromosome 14 and 12 translocations, and amplification of the chromosomal region 9A1–A5.3. Phenotypic and genetic analyses suggest that lymphomas emerge through a normal thymocyte development pathway. These findings provide genetic evidence that block of lymphocyte development at stages with RAG endonuclease activity can provoke lymphomagenesis on a background with deficient DNA damage responses.</P>
Aerodynamics of an intercity bus
Sharma, Rajnish,Chadwick, Daniel,Haines, Jonathan Techno-Press 2008 Wind and Structures, An International Journal (WAS Vol.11 No.4
A number of passive aerodynamic drag reduction methods were applied separately and then in different combinations on an intercity bus model, through wind tunnel studies on a 1:20 scale model of a Mercedes Benz Tourismo 15 RHD intercity bus. Computational fluid dynamics (CFD) modelling was also conducted in parallel to assist with flow visualisation. The commercial CFD package $CFX^{TM}$ was used. It has been found that dramatic reductions in coefficient of drag ($C_D$) of up to 70% can be achieved on the model using tapered and rounded top and side leading edges, and a truncated rear boat-tail. The curved front section allows the airflow to adhere to the bus surfaces for the full length of the vehicle, while the boat-tails reduce the size of the low pressure region at the base of the bus and more importantly, additional pressure recovery occurs and the base pressures rise, reducing drag. It is found that the CFD results show remarkable agreement with experimental results, both in the magnitude of the force coefficients as well as in their trends. An analysis shows that such a reduction in aerodynamic drag could lead to a significant 28% reduction in fuel consumption for a typical bus on intercity or interstate operation. This could translate to a massive dollar savings as well as significant emissions reductions across a fleet. On road tests are recommended.
Harvesting electrical energy from carbon nanotube yarn twist
Kim, Shi Hyeong,Haines, Carter S.,Li, Na,Kim, Keon Jung,Mun, Tae Jin,Choi, Changsoon,Di, Jiangtao,Oh, Young Jun,Oviedo, Juan Pablo,Bykova, Julia,Fang, Shaoli,Jiang, Nan,Liu, Zunfeng,Wang, Run,Kumar, P American Association for the Advancement of Scienc 2017 Science Vol.357 No.6353
<P>Mechanical energy harvesters are needed for diverse applications, including self-powered wireless sensors, structural and human health monitoring systems, and the extraction of energy from ocean waves. We report carbon nanotube yarn harvesters that electrochemically convert tensile or torsional mechanical energy into electrical energy without requiring an external bias voltage. Stretching coiled yarns generated 250 watts per kilogram of peak electrical power when cycled up to 30 hertz, as well as up to 41.2 joules per kilogram of electrical energy per mechanical cycle, when normalized to harvester yarn weight. These energy harvesters were used in the ocean to harvest wave energy, combined with thermally driven artificial muscles to convert temperature fluctuations to electrical energy, sewn into textiles for use as self-powered respiration sensors, and used to power a light-emitting diode and to charge a storage capacitor.</P>
Aerodynamics of an intercity bus
Rajnish Sharma,Daniel Chadwick,Jonathan Haines 한국풍공학회 2008 Wind and Structures, An International Journal (WAS Vol.11 No.4
A number of passive aerodynamic drag reduction methods were applied separately and then in different combinations on an intercity bus model, through wind tunnel studies on a 1:20 scale model of a Mercedes Benz Tourismo 15 RHD intercity bus. Computational fluid dynamics (CFD) modelling was also conducted in parallel to assist with flow visualisation. The commercial CFD package CFX™ was used. It has been found that dramatic reductions in coefficient of drag (CD) of up to 70% can be achieved on the model using tapered and rounded top and side leading edges, and a truncated rear boat-tail. The curved front section allows the airflow to adhere to the bus surfaces for the full length of the vehicle, while the boat-tails reduce the size of the low pressure region at the base of the bus and more importantly, additional pressure recovery occurs and the base pressures rise, reducing drag. It is found that the CFD results show remarkable agreement with experimental results, both in the magnitude of the force coefficients as well as in their trends. An analysis shows that such a reduction in aerodynamic drag could lead to a significant 28% reduction in fuel consumption for a typical bus on intercity or interstate operation. This could translate to a massive dollar savings as well as significant emissions reductions across a fleet. On road tests are recommended
The Efficacy of Herbal Supplement Danggui Buxue Tang for Relieving Menopausal Symptoms
( Eliza L. Y. Wong ),( Annie W. L. Cheung ),( C. J. Haines ),( C. C. Wang ),( Chun-kwok Wong ),( Karl W. K. Tsim ),( William K. F. Cheng ),( Ping-chung Leung ) 대한폐경학회 2022 대한폐경학회지 Vol.28 No.1
Objectives: This study aimed to further explore the efficacy and safety of Danggui Buxue Tang (DBT), a simple herbal formula, for improving the quality of life of women suffering from menopausal symptoms. Methods: A third clinical trial to determine the clinical efficacy of high-dose DBT for a period of 12 weeks was carried out. The standard Menopause-Specific Quality of Life (MENQOL) assessment chart was used for the evaluation. Safety was defined as an absence of direct estrogenic effects, serum inflammatory cytokines. Notably, interleukin IL-6, IL-8 and tumor necrosis factor TNF-α, known to be directly related to estrogenic reactions in menopause studies, were monitored. Results: The third clinical trial indicated an overall improvement in the four domains of MENQOL, offering further proof of the efficacy of DBT demonstrated in the two previous trials. The serial checks of the three cytokines related to estrogen activities did not show either upward or downward trends. The haphazard behavior reactions of the three cytokines offered indirect indications that DBT improved the MENQOL independently from estrogen activities. Conclusions: The three clinical trials using DBT to relieve menopausal syndrome have offered solid evidence for its efficacy. The uncertainty regarding whether the “phytoestrogen” contained in DBT had bioactivities similar to estrogen was alleviated through the confirmation that no strict estrogenic bioactivities were observed. The issue of safety was further clarified via laboratory platform studies on DBT, which not only showed the lack of similarity with estrogen actions but also confirmed the value of combining the two herbs in the classic formula.