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RISS 인기검색어
- 검색키워드
- 저자 : Hadis Gholipour (검색결과 2 건)
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Design and engineering of sculptured nano-structures for application in hydrophobicity
Somaye Hosseini,Hadi Savaloni,Mehran Gholipour Shahraki 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.45 No.-
The design and engineering of suitable structures for enhancement of the hydrophobic property of asurface is one of the most challenging problems. In order to achieve a superhydrophobic structure wehave designed and fabricated Mn nano-sculptured thinfilms with different shapes and dimensions,namely helical squares and helical pentagons on glass substrates. The contact angle (CA) of three liquids;a–bromonaphtalene (apolar), water and formamide (polar) to these surfaces was measured and thesurface free energy was calculated. Changes to the geometry of the structure produced results rangingfrom hydrophilic (CA = 51 ) to superhydrophobic (CA = 152 ). The superhydrophobic structure is a helicalsquare shaped structure with high porosity (deposited at 83 ) which also shows the rose petal effect withthe additional property of high adhesion. The resemblance of this structure to that of gecko feet, whichshows both high adhesion forces and superhydrophobic property is discussed. All structures investigatedin this work showed negative spreading coefficients with highest values for the largest contact angle foreach type/shape of structure. The superhydrophobic sample also acts as a sticky surface which isconfirmed by hysteresis of the contact angle obtained from advancing and receding contact anglesmeasurements. The influence of the volume of liquid drop and different surface morphologies on thewetting transition from Cassie–Baxter to Wenzel states is also reported.
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Transition nuclear protein 1 as a novel biomarker in patients with fertilization failure
Jamileh Sadat Mirsanei,Hadis Gholipour,Zahra Zandieh,Masoumeh Golestan Jahromi,Mojgan Javedani Masroor,Mehdi Mehdizadeh,Fatemehsadat Amjadi The Korean Society for Reproductive Medicine 2023 Clinical and Experimental Reproductive Medicine Vol.50 No.3
Objective: Although intracytoplasmic sperm injection (ICSI) is a way to deal with in vitro fertilization failure, 3% of couples still experience repeated fertilization failure after attempted ICSI, despite having sperm within normal parameters. These patients are a challenging group whose sperm cannot fertilize the egg during ICSI. Unfortunately, no test can predict the risk of fertilization failure. Phospholipase C zeta (PLCζ) and transition nuclear proteins (TNPs) are essential factors for chromatin packaging during sperm maturation. This study aimed to assess PLCζ1 and TNP1 expression in the sperm of patients with fertilization failure and the correlations among the DNA fragmentation index, PLCζ1 and TNP1 gene and protein expression, and the risk of fertilization failure. Methods: In this study, 12 infertile couples with low fertilization rates (<25%) and complete failure of fertilization in their prior ICSI cycles despite normal sperm parameters were chosen as the case group. Fifteen individuals who underwent ICSI for the first time served as the control group. After sperm analysis and DNA fragmentation assays, quantitative reverse-transcription polymerase chain reaction (qRT-PCR) and Western blot analyses were performed to compare the gene and protein expression of PLCζ and TNP1 in both groups. Results: DNA fragmentation was significantly higher in the fertilization failure group. The qRT-PCR and Western blot results demonstrated significantly lower PLCζ and TNP1 gene and protein expression in these patients than in controls. Conclusion: The present study showed that fertilization failure in normozoospermic men was probably due to deficient DNA packaging and expression of TNP1.
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