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Group quenching and galactic conformity at low redshift
Treyer, M,Kraljic, K,Arnouts, S,de la Torre, S,Pichon, C,Dubois, Y,Vibert, D,Milliard, B,Laigle, C,Seibert, M,Brown, M J I,Grootes, M W,Wright, A H,Liske, J,Lara-Lopez, M A,Bland-Hawthorn, J Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.477 No.2
HTR fuel coating separate effect test PYCASSO
de Groot, S.,Guillermier, P.,Sawa, K.,Escleine, J.M.,Ueta, S.,Basini, V.,Bakker, K.,Lee, Y.W.,Perez, M.,Kim, B.G. North-Holland Pub. Co 2010 Nuclear engineering and design Vol.240 No.10
The ''analytical'' PYCASSO (PYrocarbon irradiation for Creep and Swelling/Shrinkage of Objects) irradiations focus on determining the effects of neutron irradiation in the temperature range of 900-1100<SUP>o</SUP>C, excluding effects due to the presence of fuel, such as pressurization or chemical attack by fission products. These irradiations can therefore be considered separate effect tests, where only the influence of neutron fluence and temperature on coatings and coating combinations is investigated. For this purpose dedicated particles have been manufactured consisting of surrogate kernels (ZrO<SUB>2</SUB> and Al<SUB>2</SUB>O<SUB>3</SUB>) with different types of PyC/SiC/ZrC coatings and coating combinations. All specimens delivered have been extensively characterized, such that even potentially small changes due to the irradiation in dimensions, microstructure and density can be determined accurately after irradiation. Partners involved in this irradiation are CEA (France), JAEA (Japan) and KAERI (South Korea). The PYCASSO irradiations take place in the High Flux Reactor (HFR) in Petten, and are coordinated by NRG (The Netherlands). The partnership for PYCASSO was initiated by the RAPHAEL (V)HTR European 6th Framework Program and is integrated in the Generation IV International Forum VHTR Fuel and Fuel Cycle project.
Lotte E. de Groot-de Laat,Jackie McGhie,Ben Ren,René Frowijn,Frans B. Oei,Marcel L. Geleijnse 한국심초음파학회 2019 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.27 No.3
In this report, we provide an overview of a new, updated echocardiographic classification of mitral regurgitation mechanisms to provide a more comprehensive and detailed assessment of mitral valve disorders. This is relevant to modern mitral valve repair techniques, with special attention to the added value of 3D-echocardiography.
Aafke J. de Groot,Elizabeth M. Wattel,Romke van Balen,Cees M.P.M. Hertogh,Johannes C. van der Wouden 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.4
Background: We assessed the vulnerability of patients aged ≥70 years during hospital admission based on the Short Dutch Safety Management Screening (DSMS). Screening of four geriatric domains aims to prevent adverse outcomes and may support targeted discharge planning for post-acute care. We explored whether the DSMS criteria for acutely admitted patients were associated with rehabilitation-oriented care needs. Methods: This retrospective cohort study included community-dwelling patients aged ≥70 years acutely admitted to a tertiary hospital. We recorded patient demographics, morbidity, functional status, malnutrition, fall risk, and delirium and used descriptive analysis to calculate the risks by comparing the discharge destination groups. Results: Among 491 hospital discharges, 349 patients (71.1%) returned home, 60 (12.2%) were referred for geriatric rehabilitation, and 82 (16.7%) to other inpatient post-acute care. Non-home referrals increased with age from 21% (70–80 years) to 61% (>90 years). A surgical diagnosis (odds ratio [OR]=4.92; 95% confidence interval [CI], 2.03–11.95), functional decline represented by Katz-activities of daily living positive screening (OR=3.79; 95% CI, 1.76–8.14), and positive fall risk (OR=2.87; 95% CI, 1.31–6.30) were associated with non-home discharge. The Charlson Comorbidity Index did not differ significantly between the groups. Conclusion: Admission diagnosis and vulnerability screening outcomes were associated with discharge to rehabilitation-oriented care in patients >70 years of age. The usual care data from DSMS vulnerability screening can raise awareness of discharge complexity and provide opportunities to support timely and personalized transitional care.
Huse, Nils,Kim, Tae Kyu,Jamula, Lindsey,McCusker, James K.,de Groot, Frank M. F.,Schoenlein, Robert W. American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.19
<P>Solution-phase photoinduced low-spin to high-spin conversion in the Fe<SUP>II</SUP> polypyridyl complex [Fe(tren(py)<SUB>3</SUB>)]<SUP>2+</SUP> (where tren(py)<SUB>3</SUB> is tris(2-pyridylmethyliminoethyl)amine) has been studied via picosecond soft X-ray spectroscopy. Following <SUP>1</SUP>A<SUB>1</SUB> → <SUP>1</SUP>MLCT (metal-to-ligand charge transfer) excitation at 560 nm, changes in the iron L<SUB>2</SUB>- and L<SUB>3</SUB>-edges were observed concomitant with formation of the transient high-spin <SUP>5</SUP>T<SUB>2</SUB> state. Charge-transfer multiplet calculations coupled with data acquired on low-spin and high-spin model complexes revealed a reduction in ligand field splitting of ∼1 eV in the high-spin state relative to the singlet ground state. A significant reduction in orbital overlap between the central Fe-3d and the ligand N-2p orbitals was directly observed, consistent with the expected ca. 0.2 Å increase in Fe−N bond length upon formation of the high-spin state. The overall occupancy of the Fe-3d orbitals remains constant upon spin crossover, suggesting that the reduction in σ-donation is compensated by significant attenuation of π-back-bonding in the metal−ligand interactions. These results demonstrate the feasibility and unique potential of time-resolved soft X-ray absorption spectroscopy to study ultrafast reactions in the liquid phase by directly probing the valence orbitals of first-row metals as well as lighter elements during the course of photochemical transformations.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-19/ja101381a/production/images/medium/ja-2010-01381a_0007.gif'></P>
Periostin (POSTN) Regulates Tumor Resistance to Antiangiogenic Therapy in Glioma Models
Park, Soon Young,Piao, Yuji,Jeong, Kang Jin,Dong, Jianwen,de Groot, John F. American Association for Cancer Research 2016 Molecular cancer therapeutics Vol.15 No.9
<P>Periostin (POSTN) interacts with multiple integrins to coordinate a variety of cellular processes, including epithelial-to-mesenchymal transition (EMT) and cell migration. In our previous study, anti-VEGF-A therapy was associated with resistance and EMT. This study sought to determine the role of POSTN in the resistance of glioma stem cells (GSC) to antiangiogenic therapy. In mouse xenograft models of human glioma, POSTN expression was associated with acquired resistance to anti-VEGF-A therapy and had a synergistic effect with bevacizumab in prolonging survival and decreasing tumor volume. Resistance to anti-VEGF-A therapy regulated by POSTN was associated with increased expression of TGFβ1 and hypoxia-inducible factor-1α (HIF1α) in GSCs. At the molecular level, POSTN regulated invasion and expression of EMT (caveolin-1) and angiogenesis-related genes (<I>HIF1α</I> and <I>VEGF</I>-<I>A</I>) through activation of STAT3. Moreover, recombinant POSTN increased GSC invasion. Collectively, our findings suggest that POSTN plays an important role in glioma invasion and resistance to antiangiogenic therapy. <I>Mol Cancer Ther; 15(9); 2187–97. ©2016 AACR</I>.</P>