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거치상 선종의 조직학적 및 대장내시경적 특징과 p53 단백의 과발현
김상균(Sang Gyune Kim),이문성(Moon Sung Lee),김진오(Jin Oh Kim),천갑진(Gab Jin Cheon),정인섭(In Seop Jung),천영국(Young Koog Cheon),조주영(Joo Young Cho),이준성(Joon Seong Lee),진소영(So Young Jin),심찬섭(Chan Sup Shim) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Background/Aims: Serrated adenomas (SA) is a distinct form of colorectal neoplasia, in which adenomatous glands have a serrated epithelial arrangement observed in hyperplastic polyps. SA is defined as a neoplastic lesion composed of a monotonous cell population with atypical nuclei proliferating in a serrated glandular architecture. The aims were to clarify colonoscopic and histologic features, p53 protein overexpression of SA. Methods: One hundred and five SAs were obtained from 50 patients. We examined the location, size, colonoscopic findings, dysplasia, combined lesions. Twenty randomly selected cases of SA were compared with 24 cases of hyperplastic polyp and 21 cases of tubular adenoma for p53 protein overexpression. Results: Twenty-five patients (50%) had a single SA. The most common site was the sigmoid colon (30.5%). Out of 105 SAs, 83 (79%) were less than 5 mm in diameter. The endoscopic appearance showed that 52 cases of (49.5%) SAs were sessile type. The p53 protein overexpression was noted in none of hyperplastic polyps, in 55% of SAs (11/20), and in 76.2% of tubular adenomas. Conclusions: According to this study, SAs are generally sessile type sized less than 5 mm and commonly observed in the sigmoid colon. Moreover, SAs show higher overexpression rate of p53 protein than hyperplastic polyps. Thus, the careful observation is required considering its malignant potential. ( Korean J Gastroenterol 2002; 39: 350-355)