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Genome editing reveals a role for OCT4 in human embryogenesis
Fogarty, Norah M. E.,McCarthy, Afshan,Snijders, Kirsten E.,Powell, Benjamin E.,Kubikova, Nada,Blakeley, Paul,Lea, Rebecca,Elder, Kay,Wamaitha, Sissy E.,Kim, Daesik,Maciulyte, Valdone,Kleinjung, Jens,K Macmillan Publishers Limited, part of Springer Nat 2017 Nature Vol.550 No.7674
<P>Despite their fundamental biological and clinical importance, the molecular mechanisms that regulate the first cell fate decisions in the human embryo are not well understood. Here we use CRISPR-Cas9-mediated genome editing to investigate the function of the pluripotency transcription factor OCT4 during human embryogenesis. We identified an efficient OCT4-targeting guide RNA using an inducible human embryonic stem cell-based system and microinjection of mouse zygotes. Using these refined methods, we efficiently and specifically targeted the gene encoding OCT4 (POU5F1) in diploid human zygotes and found that blastocyst development was compromised. Transcriptomics analysis revealed that, in POU5F1-null cells, gene expression was downregulated not only for extra-embryonic trophectoderm genes, such as CDX2, but also for regulators of the pluripotent epiblast, including NANOG. By contrast, Pou5f1-null mouse embryos maintained the expression of orthologous genes, and blastocyst development was established, but maintenance was compromised. We conclude that CRISPR-Cas9-mediated genome editing is a powerful method for investigating gene function in the context of human development.</P>
The Servant Leadership of David Yonggi Cho
( Stephen Fogarty ) 한세대학교 영산신학연구소 2011 영산신학저널 Vol.22 No.-
David Yonggi Cho is one of the most effective church leaders of the twentieth century. While his leadership style has been characterized as charismatic, transcendent, and spiritual, Cho understands himself to be a servant leader emulating the example of Jesus and empowered by the Holy Spirit. Servant leadership posits that service to followers is the primary responsibility of leaders and the essence of ethical leadership. Servant leadership can be effective because it inspires followers to engage in servant leadership and to work for the good of the organization. The distinctive construct of servant leadership consists of a natural inclination to serve, having the priorities of followers first, organizations second, and leader last, having spirituality as the source of motivation, and engaging in self-sacrificial behavior. This can be conceptualized in six dimensions of behavior: voluntary subordination; authentic self; covenantal relationship; responsible morality; transcendental spirituality; and transforming influence. When examined through this lens Cho is a servant leader. His servant leadership and his effectiveness as a leader are likely to be enhanced by grounding his self-concept and his methodology in Christian thinking regarding the leadership example of Jesus and the implications of the relational nature of the triune God.
Cord blood banking-Where to Now?
( Paul Fogarty ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-
Cord blood contains many different types of cells including very slllall numbers of a p:lrticu]ar type of cell, known as stem cells. Cord blood stem cells are currently used in the treatment of: blood related disorders, such as leukaemia, haemoglobinopathies and some immune system and metabolic storage disorders. Some scientists have claimed thai cord blood could also potentially be used to cure diseases such as Alzheimer``s disease. Parkinson``s disease and conditions such as diabetes On the other hand others argue that there is not enough evidence to back up these claims. It may be that in the fulure morc diseases will be treated with cord blood. At present, however, much more research is needed. Evidence Based medicine has rightly become the corner slone of good practice for clinical staff and organisations yet our patients are eaSily mislead by exaggerated claims particularly form the Private sector This talk will look at the t),pes of cord Blood banking a\``ailable. The evidence base around the place of Cord Blood Banking will be reviewed along with the RCOG recommendations for Patients, Units and Individuals
“The Quarrel with Others” : W. B. Yeats and James Joyce
Anne Fogarty 한국예이츠학회 2013 한국예이츠 저널 Vol.40 No.-
이 논문은 예이츠와 조이스는 서로의 차이점으로 인해 자신들의 작품과 원리를 만들어낸다고 주장한다. 그들의 차이점들은 두 작가들에 의해 전략적으로 재조 정되고 재연됨으로써 문학적 자아를 창출하고 무의미하거나 정치적으로 제한적이지 않는 전통을 창안해 낸다. 그러나 자신들의 미학적, 작가적 안목의 차이를 강조하려는 노력에도 불구하고, 그들은 서로를 참조하고, 또 서로가 버릴 것을 여겨지는 견해를 취하고 있다. This essay argues that Yeats and Joyce create their works and artistic principles from their disagreements with each other. Their differences are strategically recast and replayed by both writers to create a sense of literary identity and invent a tradition which was neither deadening nor politically restraining. But despite their efforts to highlight the differences in their aesthetics and views of the artist, they recurrently reference each and incorporate the vision they supposedly reject.
THE SAMI GALAXY SURVEY: REVISITING GALAXY CLASSIFICATION THROUGH HIGH-ORDER STELLAR KINEMATICS
Sande, Jesse van de,Bland-Hawthorn, Joss,Fogarty, Lisa M. R.,Cortese, Luca,d’Eugenio, Francesco,Croom, Scott M.,Scott, Nicholas,Allen, James T.,Brough, Sarah,Bryant, Julia J.,Cecil, Gerald,Colless, Ma American Astronomical Society 2017 The Astrophysical journal Vol.835 No.1
<P>Recent cosmological hydrodynamical simulations suggest that integral field spectroscopy can connect the high-order stellar kinematic moments h(3) (similar to skewness) and h(4) (similar to kurtosis) in galaxies to their cosmological assembly history. Here, we assess these results by measuring the stellar kinematics on a sample of 315 galaxies, without a morphological selection, using two-dimensional integral field data from the SAMI Galaxy Survey. Proxies for the spin parameter (lambda(Re)) and ellipticity (epsilon(e)) are used to separate fast and slow rotators; there exists a good correspondence to regular and non-regular rotators, respectively, as also seen in earlier studies. We confirm that regular rotators show a strong h(3) versus V/sigma s anti-correlation, whereas quasi-regular and non-regular rotators show a more vertical relation in h(3) and V/sigma. Motivated by recent cosmological simulations, we develop an alternative approach to kinematically classify galaxies from their individual h(3) versus V/sigma signatures. Within the SAMI Galaxy Survey, we identify five classes of high-order stellar kinematic signatures using Gaussian mixture models. Class 1 corresponds to slow rotators, whereas Classes 2-5 correspond to fast rotators. We find that galaxies with similar lambda(Re)-epsilon(e) -values can show distinctly different h(3)-V/sigma signatures. Class 5 objects are previously unidentified fast rotators that show a weak h(3) versus V/sigma anti-correlation. From simulations, these objects are predicted to be disk-less galaxies formed by gas-poor mergers. From morphological examination, however, there is evidence for large stellar disks. Instead, Class 5 objects are more likely disturbed galaxies, have counter-rotating bulges, or bars in edge-on galaxies. Finally, we interpret the strong anti-correlation in h(3) versus V/sigma as evidence for disks in most fast rotators, suggesting a dearth of gas-poor mergers among fast rotators.</P>
The SAMI Galaxy Survey: observing the environmental quenching of star formation in GAMA groups
Schaefer, A L,Croom, S M,Scott, N,Brough, S,Allen, J T,Bekki, K,Bland-Hawthorn, J,Bloom, J V,Bryant, J J,Cortese, L,Davies, L J M,Federrath, C,Fogarty, L M R,Green, A W,Groves, B,Hopkins, A M,Konstant Oxford University Press 2019 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.483 No.3