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RISS 인기검색어
- 검색키워드
- 저자 : Fakhraei, Bahareh (검색결과 5 건)
- 무료
- 기관 내 무료
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Effects of dissolving microneedle fabrication parameters on the activity of encapsulated lysozyme
Fakhraei Lahiji, Shayan,Jang, Yoojung,Ma, Yonghao,Dangol, Manita,Yang, Huisuk,Jang, Mingyu,Jung, Hyungil Elsevier 2018 European journal of pharmaceutical sciences Vol.117 No.-
<P><B>Abstract</B></P> <P>Dissolving microneedle (DMN) is referred to a microscale needle that encapsulates drug(s) within a biodegradable polymer matrix and delivers it into the skin in a minimally invasive manner. Although vast majority of studies have emphasized DMN as an efficient drug delivery system, the activity of DMN-encapsulated proteins or antigens can be significantly affected due to a series of thermal, physical and chemical stress factors during DMN fabrication process and storage period. The objective of this study is to evaluate the effects of DMN fabrication parameters including polymer type, polymer concentration, fabrication and storage temperature, and drying conditions on the activity of the encapsulated therapeutic proteins by employing lysozyme (LYS) as a model protein. Our results indicate that a combination of low temperature fabrication, mild drying condition, specific polymer concentration, and addition of protein stabilizer can maintain the activity of encapsulated LYS up to 99.8 ± 3.8%. Overall, findings of this study highlight the importance of optimizing DMN fabrication parameters and paves way for the commercialization of an efficient delivery system for therapeutics.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Fakhraei Lahiji, Shayan,Seo, Seol Hwa,Kim, Suyong,Dangol, Manita,Shim, Jiyong,Li, Cheng Guo,Ma, Yonghao,Lee, Chisong,Kang, Geonwoo,Yang, Huisuk,Choi, Kang-Yell,Jung, Hyungil Elsevier 2018 Biomaterials Vol.167 No.-
<P><B>Abstract</B></P> <P>The interest in alternative material systems and delivery methods for treatment of androgenetic alopecia has been increasing in the recent decades. Topical application of valproic acid (VPA), an FDA-approved anticonvulsant drug, has been shown to effectively stimulate hair follicle (HF) regrowth by upregulating Wnt/β-catenin, a key pathway involved in initiation of HF development. Moreover, a majority of studies have suggested that cutaneous wound re-epithelialization is capable of inducing HF through Wnt/β-catenin pathway. Here, we report fabrication and evaluation of a novel VPA-encapsulating dissolving microneedle (DMN-VPA) that creates minimally invasive dermal micro-wounds upon application, significantly improving the VPA delivery efficiency. DMN-VPA not only delivers encapsulated VPA with higher accuracy than topical application, it also stimulates wound re-epithelialization signals involved in HF regrowth. Through a series of <I>in vivo</I> studies, we show that micro-wounding-mediated implantation of DMN-VPA upregulates expression of Wnt/β-catenin pathway, alkaline phosphatase, proliferating cell nuclear antigen, loricrin and HF stem cell markers, including keratin 15, and CD34 more effectively than topical application.</P>
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Lack of Association Between Helicobacter pylori Infection and Oral Lichen Planus
Pourshahidi, Sara,Fakhri, Farnaz,Ebrahimi, Hooman,Fakhraei, Bahareh,Alipour, Abbas,Ghapanchi, Janan,Farjadian, Shirin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5
Oral lichen planus is a premalignant chronic inflammatory mucosal disorder with unknown etiology. It is a multifactorial disease and in addition to genetic background, infections, stress, drug reactions are suggested as risk factors. Helicobacter pylori which is involved in development of many gastrointestinal lesions may also be implicated in oral lichen planus induction. This is of clear importance for cancer prevention and the present study was performed to determine any association between H. pylori infection and oral lichen planus in southwestern Iran. Anti H. pylori IgG levels were determined in 41 patients and 82 sex-age matched controls. The results showed no association between H. pylori infection and oral lichen planus (51% in patients vs. 66% in control). or any of its clinical presentations.
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Dangol, Manita,Kim, Suyong,Li, Cheng Guo,Fakhraei Lahiji, Shayan,Jang, Mingyu,Ma, Yonghao,Huh, Inyoung,Jung, Hyungil Elsevier 2017 Journal of controlled release Vol.265 No.-
<P><B>Abstract</B></P> <P>Natural products such as caffeine have been found to be effective in reducing body weight through lipolysis. Here, we report the successful loading of caffeine onto dissolving microneedle following inhibition of its crystal growth by hyaluronic acid (HA), the matrix material of the dissolving microneedle (DMN). Further, the anti-obesity activity of caffeine was evaluated in high-fat diet-induced obese C57BL/6J mice. After 6weeks of caffeine loaded dissolving microneedle patch (CMP) administration, lipolysis improved significantly as shown by leptin and adiponectin activity, which resulted in considerable weight loss of about 12.8±0.75% in high-fat diet-induced obese mice. Comparison of the levels of triglyceride, total cholesterol, high-density lipoprotein (HDL)-cholesterol, and low-density lipoprotein (LDL)-cholesterol after CMP administration with the initial levels in obese mice indicated significant anti-obesity activity of CMP. These findings suggested that a novel CMP with an increased amount of caffeine loaded onto DMN has therapeutic activity against obesity.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Silicon carbide (SiC) nanotubes as potential sensors for organophosphate molecules
Keyumars Hassanzadeh,Keivan Akhtari,Bahareh Fakhraei,Ghazal Akhtari,Halaleh Hassanzadeh 한국물리학회 2017 Current Applied Physics Vol.17 No.5
The detection and clean-up of the organophosphate (OP) compounds have special importance for those who work in the field of health and governments due to the bad effects of these compounds on human health. In this paper, we have employed the PBE level of theory and ultrasoft pseudopotentials to investigate the ability of silicon carbide nanotubes (SiCNTs) as sensors for organophosphate detection. We found that the binding energy and charge transfer for adsorption of OP on (6,0) SiCNT represents the formation of a strong bond. However, the DE Gap demonstrates the significant changes (12%) in the electronic properties of (10,0) SiC nanotubes which could induce considerable alteration in the SiCNT electrical conductivity. According to the results, the OP can be adsorbed on SiCNT and these types of nanotubes can be promising candidates for detecting organophosphate compounds. The non-equilibrium Green function (NEGF) method shows good performance for the sensor sensitivity.
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