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OZONE SENSING PROPERTIES OF THERMALLY EVAPORATED In2O3-BASED THIN FILMS
K. ARSHAK,G. HICKEY,E. FORDE,J. HARRIS 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.4
Ozone sensing properties of mixed oxides of In2O3, ZnO, and SnO2 in the form of thin films are explored. Exposure to ozone causes defects in the materials, and subsequently causes changes in the materials properties. In this work, a cost-effective, room temperature, real-time ozone monitoring device has been developed. The fabricated sensors are capable of detecting threshold ozone safety levels proposed by the World Health Organization (WHO) while operating at room temperature. Room temperature operation offers many advantages over high temperature operation, such as reduced power consumption, reduced fabrication costs, and ease of implementation into portable devices, such as laptops and mobile phones. The fabrication of these sensors was carried out by means of an Edwards E306A Coating System. Various mixtures of In2O3, ZnO, and snO2 were deposited in a rectangular pattern on top of copperinterdigitated electrodes. X-ray Photo Spectroscopy (XPS) analysis showed that there were levels of impurities in the sensor samples, which were dependant on the fabrication process and parameters. XPS analysis also gave a detailed account of the shifts in binding energies of the thin oxide layers. The results presented show that the highest response to environmentally relevant ozone concentrations is achieved with a very thin sensing layer and a high deposition rate. The performance of the sensors has been investigated and compared.
Modality-Dependent Impact of Hallucinations on Low-Frequency Fluctuations in Schizophrenia
Hare, S. M.,Ford, J. M.,Ahmadi, A.,Damaraju, E.,Belger, A.,Bustillo, J.,Lee, H. J.,Mathalon, D. H.,Mueller, B. A.,Preda, A. Oxford University Press 2017 Schizophrenia bulletin Vol.43 No.2
<P>Prior resting-state functional magnetic resonance imaging (fMRI) analyses have identified patterns of functional connectivity associated with hallucinations in schizophrenia (Sz). In this study, we performed an analysis of the mean amplitude of low-frequency fluctuations (ALFF) to compare resting state spontaneous low-frequency fluctuations in patients with Sz who report experiencing hallucinations impacting different sensory modalities. By exploring dynamics across 2 low-frequency passbands (slow-4 and slow-5), we assessed the impact of hallucination modality and frequency range on spatial ALFF variation. Drawing from a sample of Sz and healthy controls studied as part of the Functional Imaging Biomedical Informatics Research Network (FBIRN), we replicated prior findings showing that patients with Sz have decreased ALFF in the posterior brain in comparison to controls. Remarkably, we found that patients that endorsed visual hallucinations did not show this pattern of reduced ALFF in the back of the brain. These patients also had elevated ALFF in the left hippocampus in comparison to patients that endorsed auditory (but not visual) hallucinations. Moreover, left hippocampal ALFF across all the cases was related to reported hallucination severity in both the auditory and visual domains, and not overall positive symptoms. This supports the hypothesis that dynamic changes in the ALFF in the hippocampus underlie severity of hallucinations that impact different sensory modalities.</P>
A new physical interpretation of optical and infrared variability in quasars
Ross, Nicholas P,Ford, K E Saavik,Graham, Matthew,McKernan, Barry,Stern, Daniel,Meisner, Aaron M,Assef, Roberto J,Dey, Arjun,Drake, Andrew J,Jun, Hyunsung D,Lang, Dustin Oxford University Press 2018 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.480 No.4
Dupilumab Long-term Safety and Efficacy in Patients with Asthma: Liberty Asthma Traverse
( Hae Sim Park ),( Michael E. Wechsler ),( Linda B. Ford ),( Jorge F. Maspero ),( Ian D. Pavord ),( Yuji Tohda ),( David Langton ),( Christian Domingo ),( Alberto Papi ),( Arnaud Bourdin ),( Henrik Wa 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0
Background Dupilumab, a fully human monocolonal antibody, blocks the shared receptor component for interleukin (IL) 4 and IL 13, key and central drivers of type 2 inflammation in multiple diseases. The efficacy and safety of dupilumab in asthma have been demonstrated up to 52 weeks in phase 2 and phase 3 studies. This open-label extension (OLE) study (NCT02134028) assessed long-term safety and efficacy of dupilumab in adult and adolescent patients who had completed a dupilumab asthma study (phase 2b DRI, phase 2 EXPEDITION, phase 3 QUEST, or phase 3 VENTURE). Methods Patients with moderate-to-severe or oral corticosteroid (OCS)-dependent severe asthma received add on subcutaneous dupilumab 300 mg every 2 weeks (q2w) up to 96 weeks. Treatment-emergent adverse events (TEAEs), annualized rate of severe asthma exacerbations (AER) during the treatment period, change from parent study baseline (PSBL) in forced expiratory volume in 1 second (FEV1), and biomarkers up to Week 96 were assessed. Results 2,282 patients were enrolled overall. Patient safety profile was consistent with the parent studies (Table). The low unadjusted AER and improvement in FEV1 observed in the parent studies were sustained during the OLE. Similar efficacy was seen in patients with elevated type 2 biomarkers from DRI/QUEST. By Week 96, blood eosinophils decreased to below-PSBL levels in patients from DRI/QUEST and were near-PSBL levels in patients from VENTURE; total IgE levels decreased by 82% (median percent change from PSBL). Conclusion Long-term use of dupilumab was well tolerated and showed sustained efficacy in asthma patients up to 96 weeks.
A Mid-IR Selected Changing-look Quasar and Physical Scenarios for Abrupt AGN Fading
Stern, Daniel,McKernan, Barry,Graham, Matthew J.,Ford, K. E. S.,Ross, Nicholas P.,Meisner, Aaron M.,Assef, Roberto J.,Baloković,, Mislav,Brightman, Murray,Dey, Arjun,Drake, Andrew,Djorgovski, S. American Astronomical Society 2018 The Astrophysical journal Vol.864 No.1
Modelling the capture of spray droplets by barley
Cox, S.J.,Salt, D.W.,Lee, B.E.,Ford, M.G. Techno-Press 2002 Wind and Structures, An International Journal (WAS Vol.5 No.2
This paper presents some of the results of a project whose aim has been to produce a full simulation model which would determine the efficacy of pesticides for use by both farmers and the bio-chemical industry. The work presented here describes how crop architecture can be mathematically modelled and how the mechanics of pesticide droplet capture can be simulated so that if a wind assisted droplet-trajectory model is assumed then droplet deposition patterns on crop surfaces can be predicted. This achievement, when combined with biological response models, will then enable the efficacy of pesticide use to be predicted.
임현섭,Leslie L. Domier,Chan-Yong Jang,Jiryun Nam,Meijia Li,홍진성,배한홍,Ho-Jong Ju,김홍기,Richard E. Ford 한국식물병리학회 2012 Plant Pathology Journal Vol.28 No.2
Potyviruses express their RNA genomes through the production of polyproteins that are processed in host cells by three virus-encoded proteases. Soybean plants produce large amounts of protease inhibitors during seed development and in response to wounding that could affect the activities of these proteases. The in vitro activities of two of the proteases of Soybean mosaic virus (SMV) and Tobacco vein mottling virus (TVMV) were compared in the rabbit reticulocyte lysate in vitro translation system using synthetic RNA transcripts. Transcripts produced from SMV and TVMV cDNAs that included the P1 and helper component-protease (HCPro)coding regions directed synthesis of protein products that were only partially processed. Unprocessed polyproteins were not detected from transcripts that included all of the P1, HC-Pro, P3 and portions of the cylindrical inclusion protein coding regions of either virus. Addition of soybean trypsin inhibitor to in vitro translation reactions increased the accumulation of the unprocessed polyprotein from TVMV transcripts, but did not alter the patterns of proteins produced from SMV. These experiments suggest that SMV- and TVMVencoded proteases are differentially sensitive to protease inhibitors.
Lim, Hyoun-Sub,Jang, Chan-Yong,Nam, Ji-Ryun,Li, Meijia,Hong, Jin-Sung,Bae, Han-Hong,Ju, Ho-Jong,Kim, Hong-Gi,Ford, Richard E.,Domier, Leslie L. The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.2
Potyviruses express their RNA genomes through the production of polyproteins that are processed in host cells by three virus-encoded proteases. Soybean plants produce large amounts of protease inhibitors during seed development and in response to wounding that could affect the activities of these proteases. The in vitro activities of two of the proteases of Soybean mosaic virus (SMV) and Tobacco vein mottling virus (TVMV) were compared in the rabbit reticulocyte lysate in vitro translation system using synthetic RNA transcripts. Transcripts produced from SMV and TVMV cDNAs that included the P1 and helper component-protease (HC-Pro) coding regions directed synthesis of protein products that were only partially processed. Unprocessed poly-proteins were not detected from transcripts that included all of the P1, HC-Pro, P3 and portions of the cylindrical inclusion protein coding regions of either virus. Addition of soybean trypsin inhibitor to in vitro translation reactions increased the accumulation of the unprocessed polyprotein from TVMV transcripts, but did not alter the patterns of proteins produced from SMV. These experiments suggest that SMV-and TVMV-encoded proteases are differentially sensitive to protease inhibitors.