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      • SCOPUSKCI등재

        Validation of Combs prognostic scoring system in Indian recurrent glioma patients treated with re-radiation

        Debnarayan Dutta(Debnarayan Dutta ),Meenu Jose(Meenu Jose ),Sruthi Kalavagunta(Sruthi Kalavagunta ),Ajay Sasidharan(Ajay Sasidharan ),Haridas Nair(Haridas Nair ),Annex H. Edappattu(Annex H. Edappattu 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1

        Purpose: Retrospective audit of recurrent glioma patients treated by different fractionation schedules and to validate the modified Combs prognostic score in Indian patient cohort. Materials and Methods: Between Jan 2009 and June 2022, 66 recurrent gliomas patients treated with standard adjuvant treatment—radiation (RT) ± temozolomide (chemotherapy)—and re-treated with RT (± chemotherapy) were categorized as per modified Combs prognostic criteria and outcomes were compared. Results: Sixty-six patients with recurrent gliomas who received reirradiation (re-RT) were audited—53% males; 61% Karnofsky performance status (KPS) ≥80 at time of re-RT; median age 41.5 years (range, 6 to 70 years); 67% <50 years; primary histology low-grade glioma in 33% ; grade III 27%, grade IV 40%; initial median dose of 60 Gy equivalent dose in 2 Gy fractions (EQD2); maximum safe resection at recurrence 41%; mean and median follow-up 78 ± 51 months and 66 months. Mean time interval between RT was 46.4 ± 39 months. Mean planning target volume (PTV) volume in conventional RT (Conv-RT), hypofractionated RT (Hypo-RT), and ultra-hypofractionated RT (UF-RT) was 226.1 ± 140.7 mL, 162.8 ± 123.3 mL, and 143.3 ± 145.8 mL. Mean dose for Conv-RT, Hypo-RT, and UF-RT was 50 Gy (range, 40 to 60), 31 Gy (range, 20 to 40), and 20 Gy (range, 10 to 30). Mean overall survival (OS) in Conv-RT, Hypo-RT, and UF-RT cohort was 18.8 months (range, 2.4 to 76.8); 6.6 months (range, 2 to 17.4), and 13.9 months (range, 3 to 131.9). Median OS as per Combs criteria were 16.6 months (Group a), 24.6 months (Group b), 4.6 months (Group c), and 3 months (Group d). Significant survival benefit was with good KPS score (KPS >80 vs. <80; 20.46 vs. 5.25 months; p < 0.001), patients receiving salvage chemotherapy (20.46 vs. 6.96 months; p = 0.001), and patients received re-RT biological equivalent dose (BED3) >80 Gy (16.62 vs. 5.48 months; p = 0.03). Median overall survival (OS) in our patient cohort and Combs cohort in Group a was 16.6 and 19.5 months; Group b was 24.6 and 11.3 months; Group c was 4.7 and 8.1 months, and Group d was 2 and 5.5 months, respectively. Six months survival in our patient cohort and Combs cohort in Groups a, b, c, d were 100%, 92%, 34%, 17% and 94%, 79%, 70%, 41%, respectively. Twelve months survival in our patient cohort and Combs cohort in Groups a, b, c, d were 88%, 74%, 22%, 0% and 88%, 47%, 22%, 7%, respectively. Conclusion: Modified Combs prognostic factors predicts OS and is applicable in Indian subcontinent patient population.

      • Evidence of Multimeric Forms of HSP70 with Phosphorylation on Serine and Tyrosine Residues - Implications for Roles of HSP70 in Detection of GI Cancers

        Dutta, Anand,Girotra, Mohit,Merchant, Nipun,Nair, Padmanabhan,Dutta, Sudhir Kumar Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

        Background: Heat-shock protein70 (HSP70) are intracellular protein chaperones, with emerging evidence of their association with various diseases. We have previously reported significantly elevated plasma-HSP70 (pHSP70) in pancreatic cancer. Current methods of pHSP70 isolation are ELISA-based which lack specificity due to cross-reactivity by similarities in the amino-acid sequence in regions of the protein backbone resulting in overestimated HSP70 value. Materials and Methods: This study was undertaken to develop a methodology to capture all isoforms of pHSP70, while further defining their tyrosine and serine phosphorylation status. Results: The methodology included gel electrophoresis on centrifuged supernatant obtained from plasma incubated with HSP70 antibody-coupled beads. After blocking non-specific binding sites, blots were immunostained with monoclonal-antibody specific for human-HSP70, phosphoserine and phosphotyrosine. Conclusions: Our novel immunocapture approach has distinct advantages over the commercially available methods of pHSP70 quantification by allowing isolation of molecular aggregates of HSP70 with additional ability to precisely distinguish phosphorylation state of HSP70 molecules at serine and tyrosine residues.

      • Visible‐Near Infrared Absorbing Polymers Containing Thienoisoindigo and Electron‐Rich Units for Organic Transistors with Tunable Polarity

        Dutta, Gitish K.,Han, A‐,Reum,Lee, Junghoon,Kim, Yiho,Oh, Joon Hak,Yang, Changduk WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.42

        <P><B>Abstract</B></P><P>Systematic creation of polymeric semiconductors from novel building blocks is critical for improving charge transport properties in organic field‐effect transistors (OFETs). A series of ultralow‐bandgap polymers containing thienoisoindigo (TIIG) as a thiophene analogue of isoindigo (IIG) is synthesized. The UV‐Vis absorptions of the TIIG‐based polymers (<B>PTIIG‐T</B>, <B>PTIIG‐Se</B>, and <B>PTIIG‐DT</B>) exhibit broad bands covering the visible to near‐infrared range of up to 1600 nm. All the polymers exhibit unipolar p‐channel operations with regard to gold contacts. <B>PTIIG‐DT</B> with centrosymmetric donor exhibits a maximum mobility of 0.20 cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP> under gold contacts, which is higher than those of the other polymers containing axisymmetric donors. Intriguingly, OFETs fabricated with aluminum electrodes show ambipolar charge transport with hole and electron mobilities of up to 0.28 (<B>PTIIG‐DT</B>) and 0.03 (<B>PTIIG‐T</B>) cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>, respectively. This is a record value for the hitherto reported TIIG‐based OFETs. The finding demonstrates that TIIG‐based polymers can potentially function as either unipolar or ambipolar semiconductors without reliance on the degree of electron affinity of the co‐monomers.</P>

      • SCISCIESCOPUS

        Some new DTPA-N,N''-bis(amides) functionalized by alkyl carboxylates: Synthesis, complexation and stability properties

        Dutta, S.,Kim, S.K.,Patel, D.B.,Kim, T.J.,Chang, Y. Pergamon Press 2007 Polyhedron Vol.26 No.14

        A new series of DTPA-bis(amides) (1a-1l) significantly enhance thermodynamic stabilities of the corresponding Gd(III) complexes as compared with related DTPA-BMA. Yet, the relaxivities (R<SUB>1</SUB> and R<SUB>2</SUB>) drop significantly in an aqueous solution, whereas they increase by 6-10 fold in aqueous hydroxypropyl-β-cyclodextrin solutions.

      • Self-Supported Nickel Iron Layered Double Hydroxide-Nickel Selenide Electrocatalyst for Superior Water Splitting Activity

        Dutta, Soumen,Indra, Arindam,Feng, Yi,Song, Taeseup,Paik, Ungyu American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.39

        <P>The design of efficient, low-cost, and stable electrocatalyst systems toward energy conversion is highly demanding for their practical use. Large scale electrolytic water splitting is considered as a promising strategy for clean and sustainable energy production. Herein, we report a self-supported NiFe layered double hydroxide (LDH)-NiSe electrocatalyst by stepwise surface-redox-etching of Ni foam (NF) through a hydrothermal process. The as-prepared NiFe LDH-NiSe/NF catalyst exhibits far better performance in alkaline water oxidation, proton reduction, and overall water splitting compared to NiSex/NF or NiFe LDH/NF. Only 240 mV overpotential is required to obtain a water oxidation current density of 100 mA cm(-2) , whereas the same for the hydrogen evolution reaction is 276 mV in 1.0 M KOH. The synergistic effect from NiSe and NiFe LDH leads to the evolution of a highly efficient catalyst system for water splitting by achieving 10 mA cm (-2) current density at only 1.53 V in a two-electrode alkaline electrolyzer. In addition, the designed electrode produces stable performance for a long time even at higher current density to demonstrate its robustness and prospective as a real-life energy conversion system.</P>

      • SCOPUSKCI등재

        On a Problem Posed by Belcastro and Sherman

        Dutta, Jutirekha Department of Mathematics 2016 Kyungpook mathematical journal Vol.56 No.1

        In this paper, we compute the number of distinct centralizers and commutativity degree of a class of finite groups. These computations produce a further class of examples of groups answering one question raised by Belcastro and Sherman and another one raised by Lescot.

      • Green function of correlated genes in a minimal mechanical model of protein evolution

        Dutta, Sandipan,Eckmann, Jean-Pierre,Libchaber, Albert,Tlusty, Tsvi National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.20

        <▼1><P><B>Significance</B></P><P>Many protein functions involve large-scale motion of their amino acids, while alignment of their sequences shows long-range correlations. This has motivated search for physical links between genetic and phenotypic collective behaviors. The major challenge is the complex nature of protein: nonrandom heteropolymers made of 20 species of amino acids that fold into a strongly coupled network. In light of this complexity, simplified models are useful. Our model describes protein in terms of the Green function, which directly links the gene to force propagation and collective dynamics in the protein. This allows for derivation of basic determinants of evolution, such as fitness landscape and epistasis, which are often hard to calculate.</P></▼1><▼2><P>The function of proteins arises from cooperative interactions and rearrangements of their amino acids, which exhibit large-scale dynamical modes. Long-range correlations have also been revealed in protein sequences, and this has motivated the search for physical links between the observed genetic and dynamic cooperativity. We outline here a simplified theory of protein, which relates sequence correlations to physical interactions and to the emergence of mechanical function. Our protein is modeled as a strongly coupled amino acid network with interactions and motions that are captured by the mechanical propagator, the Green function. The propagator describes how the gene determines the connectivity of the amino acids and thereby, the transmission of forces. Mutations introduce localized perturbations to the propagator that scatter the force field. The emergence of function is manifested by a topological transition when a band of such perturbations divides the protein into subdomains. We find that epistasis—the interaction among mutations in the gene—is related to the nonlinearity of the Green function, which can be interpreted as a sum over multiple scattering paths. We apply this mechanical framework to simulations of protein evolution and observe long-range epistasis, which facilitates collective functional modes.</P></▼2>

      • Polycyclic aromatic hydrocarbons and volatile organic compounds in biochar and biochar-amended soil: a review

        Dutta, Tanushree,Kwon, Eilhann,Bhattacharya, Satya Sundar,Jeon, Byong Hun,Deep, Akash,Uchimiya, Minori,Kim, Ki-Hyun Wiley (Blackwell Publishing) 2017 Global change biology. Bioenergy Vol.9 No.6

        <P>Residual pollutants including polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), and carbon (aceous) nanoparticles are inevitably generated during the pyrolysis of waste biomass and remain on the solid coproduct called biochar. Such pollutants could have adverse effects on the plant growth as well as microbial community in soil. Although biochar has been proposed as a 'carbon negative strategy' to mitigate the greenhouse gas emissions, the impacts of its application with respect to long-term persistence and bioavailability of hazardous components are not clear. Moreover, the co-occurrence of low molecular weight VOCs with PAHs in biochar may exert further phytotoxic effects. This review describes the basic need to unravel key mechanisms driving the storage vs. emission of these organics and the dynamics between the sorbent (biochar) and soil microbes. Moreover, there is an urgent need for standardized methods for quantitative analysis of PAHs and VOCs in biochar under environmentally relevant conditions. This review is also extended to cover current research gaps including the influence of biochar application on the short- and long-term fate of PAHs and VOCs and the proper control tactics for biochar quality and associated risk.</P>

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