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증례 : 소화기 ; 미분화 암종이 동반된 췌장의 파골세포 모양 거대세포종양 1예
김금하 ( Geum Ha Kim ),구양서 ( Yang Suh Ku ),김현옥 ( Hyun Ok Kim ),김길현 ( Kil Hyun Kim ),김건국 ( Koen Kuk Kim ),정동해 ( Dong Hae Jung ),김연석 ( Yeon Suk Kim ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5
본 증례는 췌장의 미부에 발생한 미분화 암종이 동반된 파골세포 모양 거대세포종양의 증례이며 림프절 전이나 원격전이를 보이지 않아 근치적 절제를 시행할 수 있었고, 보조항암화학요법을 이용하여 치료 중이어서 질환에 관한 고찰 및 국내 증례들을 종합하여 보고하는 바이다. An osteoclast-like giant cell tumor of the pancreas is a very rare neoplasm, with only three cases reported in Korea. Due to the rarity of this tumor type, few clinical data are available. We present a case of undifferentiated carcinoma with osteoclast-like giant cell tumor arising in the tail of the pancreas in a 72-year-old woman hospitalized to evaluate epigastric pain and a palpable abdominal mass. Magnetic resonance imaging revealed the presence of a large enhancing mass with septation arising from the tail of the pancreas. A distal pancreatectomy with splenectomy was performed. The pathological diagnosis was undifferentiated carcinoma with osteoclast-like giant cell tumor. Here, we describe the histopathological and immunohistochemical findings and review the clinical features of the cases reported in the Korean literature. (Korean J Med 77:610-615, 2009)
Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G
( David J Stanley ),( Koen Bartholomeeusen ),( David C Crosby ),( Dong Yong Kim ),( Eunju Kwon ),( Linda Yen ),( Nathalie Caretta Cartazo ),( Ming Li ),( Stefanie J?ger ),( Jeremy Mason Herr ),( Fumia 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Cellular restriction factors help to defend humans against human immunodeficiency virus (HIV). HIV accessory proteins hijack at least three different Cullin-RING ubiquitin ligases, which must be activated by the small ubiquitin-like protein NEDD8, in order to counteract host cellularrestriction factors. We found that conjugation of NEDD8 to Cullin-5 by the NEDD8-conjugating enzyme UBE2F is required for HIV Vif-mediated degradation of the host restriction factor APOBEC3G (A3G). Pharmacological inhibition of the NEDD8 E1 by MLN4924 or knockdown of either UBE2F or its RING-protein binding partner RBX2 bypasses the effect of Vif, restoring the restriction of HIV by A3G. NMR mapping and mutational analyses define specificity determinants of the UBE2F NEDD8 cascade. These studies demonstrate that disrupting host NEDD8 cascades presents a novel antiretroviral therapeutic approach enhancing the ability of the immune system to combat HIV.