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- 저자 : Dilip Thakur (검색결과 3 건)
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( Vikash Gautam ),( Dilip Thakur ),( Bishnu Hari Paudel ),( Kopila Agrawal ),( Madhab Lamsal ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: To correlate brainstem auditory evoked potentials` (BAEPs) amplitude and latency within different thyroid status (hypothyroidism, hyperthyroidism and euthyroidism). Methods: BAEP and Thyroid Function Tests (TFT) were assessed in consenting 75 subjects (hypothyroid=24, hyperthyroid=25, euthyroid= 26). The mean age in hypothyroid, hyperthyroid, and euthyroid group were 31.46±4.191; 31.52±4.134 and 27.12±2.732 respectively. The BAEP parameters viz, wave I-V latencies, interpeak latencies and amplitudes were recorded. One way ANOVA was used to compare BAEP parameters among three groups and Pearson`s correlation to fi nd relation between thyroid hormones (fT3, fT4, TSH) and BAEP parameters. P value less than 0.05 was considered statistically signifi cant. Results: Wave I (1.78±0.21 vs. 1.64±0.22, vs. 1.56±0.15, p= 0.001), wave III (3.96±0.19 vs. 3.90±0.30 vs. 3.74±0.30, p= 0.001) and wave V (5.97±0.36 vs. 5.91±0.37 vs. 5.60±0.24; p= 0.001) latencies (ms) were signifi cantly more in hypothyroid and hyperthyroid than euthyroid. Wave interval latencies (ms) III-V (2.01±0.32 vs. 2.01±0.41 vs. 1.86±0.32, p= 0.044) and I-V (4.19±0.43 vs. 4.26±0.41 vs. 4.03±0.28, p= 0.007) were longer in hypothyroid and hyperthyroid than euthyroid. Also, the wave I-V amplitude (μV) was more in hypo-hyperthyroid than euthyroid (0.15±0.11 vs. 0.22±0.17 vs. 0.20±0.16, p= 0.052). TSH & Wave I-V amplitude (r= -0.193, p= 0.04); fT3 and wave I latency (r= -0.269, p=0.004) were negatively correlated. However, a positive correlation was between TSH & wave I latency (r= 0.285, p=0.002). Conclusion: Both hypo- and hyperthyroidism led to conduction delay in auditory neurons in adults, possibly adversely affecting function of myelin since, T3 and T4 are known to affect myelinization and synaptic transmission. The prominent auditory evoked potential abnormalities in hypothyroidism and less change in hyperthyroidism are consistent with a possibility that the auditory neuropathy is more common in thyroid defi ciency than its excess.
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Prem Bhattarai,Bishnu H. Paudel,Dilip Thakur,Balkrishna Bhattarai,Bijay Subedi,Rita Khadka 대한직업환경의학회 2018 대한직업환경의학회지 Vol.30 No.-
Background: Despite the successful adaptation to high altitude, some differences do occur due to long term exposure to the hypoxic environment. The effect of long term high altitude exposure on cardiac autonomic adjustment during basal and post-exercise recovery is less known. Thus we aimed to study the differences in basal cardiac autonomic adjustment and its response to exercise in highlanders and to compare it with lowlanders. Methods: The study was conducted on 29 healthy highlander males who were born and brought up at altitude of 3000 m and above from the sea level, their cardiac autonomic adjustment was compared with age, sex, physical activity and ethnicity-matched 29 healthy lowlanders using Heart Rate Variability (HRV) during rest and recovery from sub-maximal exercise (3 m step test). Intergroup comparison between the highlanders and lowlanders and intragroup comparison between the rest and the postexercise recovery conditions were done. Results: Resting heart rate and HRV during rest was comparable between the groups. However, heart rate recovery after 3 min step test was faster in highlanders (p 〈 0.05) along with significantly higher LF power and total power during the recovery phase. Intragroup comparison of highlanders showed higher SDNN (p 〈 0.05) and lower LF/HF ratio (p〈 0.05) during recovery phase compared to rest which was not significantly different in two phases in lowlanders. Further highlander showed complete recovery of RMSSD, NN50, pNN50 and HF power back to resting level within five minutes, whereas, these parameters failed to return back to resting level in lowlanders within the same time frame. Conclusion: Highlanders completely recovered back to their resting state within five minutes from cessation of step test with parasympathetic reactivation; however, recovery in lowlanders was delayed.
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Vibration upshot of operating mechanical sewing machine
Prakash Kumar Yadav,Ram Lochan Yadav,Deepak Sharma,Dev Kumar Shah,Niraj Khatri Sapkota,Dilip Thakur,Nirmala Limbu,Md Nazrul Islam 대한직업환경의학회 2017 대한직업환경의학회지 Vol.29 No.-
Background: Most of the people associated with tailoring occupation in Nepal are still using mechanical sewing machine as an alternative of new technology for tailoring. Common peroneal nerves of both right and left legs are exposed to strenuous and chronic stress exerted by vibration and paddling of mechanical sewing machine. Methods: The study included 30 healthy male tailors and 30 healthy male individuals. Anthropometric variables as well as cardio respiratory variables were determined for each subject. Standard Nerve Conduction Techniques using constant measured distances were applied to evaluate common peroneal nerve (motor) in both legs of each individual. Data were analyzed and compared between study and control groups using Man Whitney U test setting the significance level p ≤ 0.05. Results: Anthropometric and cardio respiratory variables were not significantly altered between the study and control groups. The Compound muscle action potential (CMAP) latency of common peroneal nerves of both right [(11.29 ± 1.25 vs. 10.03 ± 1.37), P < 0.001] and left [(11.28 ± 1.38 vs. 10.05 ± 1.37), P < 0.01] legs was found to be significantly prolonged in study group as compared to control group. The Amp-CMAP of common peroneal nerves of both right [(4.57 ± 1.21 vs. 6.22 ± 1.72), P < 0.001] and left [(4.31 ± 1.55 vs. 6.25 ± 1.70), P < 0.001] legs was found significantly reduced in study group as compared to control group. Similarly, the motor nerve conduction velocity (MNCV) of common peroneal nerves of both right [(43.72 ± 3.25 vs. 47.49 ± 4.17), P < 0.001] and left [(42.51 ± 3.82 vs. 46.76 ± 4.51), P < 0.001] legs was also found to be significantly reduced in study group in comparison to control group. Conclusion: Operating mechanical sewing machine by paddling chronically and arduously could have attributed to abnormal nerve conduction study parameters due to vibration effect of the machine on right and left common peroneal nerves. The results of present study follow the trend towards presymptomatic or asymptomatic neuropathy similar to subclinical neuropathy.
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