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Kim, You Song,Chun, Byong Sun,Kim, Deok-kee,Hwang, Jae Yeon,Kim, Soon Sub,Rhee, J.R.,Kim, Keewon,Kim, Taewan,Kim, Young Keun IEEE 2006 IEEE transactions on magnetics Vol.42 No.10
The typical double-barrier magnetic tunnel junction (DMTJ) structure examined in this paper consists of a Ta 45/Ru 9.5/IrMn 10/CoFe 7/AlO<SUB>x</SUB>/free layer/AlO<SUB>x</SUB>/CoFe 7/IrMn 10/Ru 60 (nm). The free layer consists of an Ni<SUB>16</SUB>Fe<SUB>62</SUB>Si<SUB>8</SUB>B<SUB>14</SUB> 7 nm, Co<SUB>90</SUB>Fe<SUB>10</SUB> (fcc) 7 nm, or CoFe t<SUB>1</SUB>/NiFeSiB t<SUB>2</SUB>/CoFe t<SUB>1</SUB> layer in which the thicknesses t<SUB>1</SUB> and t<SUB>2</SUB> are varied. The DMTJ with an NiFeSiB-free layer had a tunneling magnetoresistance (TMR) of 28%, an area-resistance product (RA) of 86 k Ω μm<SUP>2</SUP>, a coercivity (H<SUB>c</SUB>) of 11 Oe, and an interlayer coupling field (H<SUB>i</SUB>) of 20 Oe. To improve the TMR ratio and RA, a DMTJ comprising an amorphous NiFeSiB layer that could partially substitute for the CoFe free layer was investigated. This hybrid DMTJ had a TMR of 30%, an RA of 68 k Ωμ m<SUP>2</SUP>, and a H<SUB>c</SUB> of 11 Oe, but an increased H<SUB>i</SUB> of 37 Oe. We confirmed by atomic force microscopy and transmission electron microscopy that H<SUB>i</SUB> increased as the thickness of NiFeSiB decreased. When the amorphous NiFeSiB layer was thick, it was effective in retarding the columnar growth which usually induces a wavy interface. However, if the NiFeSiB layer was thin, the roughness was increased and H<SUB>i</SUB> became large because of the magnetostatic Ne´el coupling.
Kim, Jong Hyun,Park, Bo Gi,Kim, Suel-Kee,Lee, Dong-Hyun,Lee, Gyung Gyu,Kim, Deok-Ho,Choi, Byung-Ok,Lee, Kyu Back,Kim, Jong-Hoon Elsevier 2019 Acta Biomaterialia: structure-property-function re Vol.95 No.-
<P><B>Abstract</B></P> <P>Bioengineering approaches to regulate stem cell fates aim to recapitulate the <I>in vivo</I> microenvironment. In recent years, manipulating the micro- and nano-scale topography of the stem cell niche has gained considerable interest for the purposes of controlling extrinsic mechanical cues to regulate stem cell fate and behavior <I>in vitro</I>. Here, we established an optimal nanotopographical system to improve 3-dimensional (3D) differentiation of pancreatic cells from human pluripotent stem cells (hPSCs) by testing gradient-pattern chips of nano-scale polystyrene surface structures with varying sizes and shapes. The optimal conditions for 3D differentiation of pancreatic cells were identified by assessing the expression of developmental regulators that are required for pancreatic islet development and maturation. Our results showed that the gradient chip of pore-part 2 (Po-2, 200–300 nm diameter) pattern was the most efficient setting to generate clusters of pancreatic endocrine progenitors (PDX1+ and NGN3+) compared to those of other pore diameters (Po-1, 100–200 or Po-3, 300–400 nm) tested across a range of pillar patterns and flat surfaces. Furthermore, the Po-2 gradient pattern-derived clusters generated islet-like 3D spheroids and tested positive for the zinc-chelating dye dithizone. The spheroids consisted of more than 30% CD200 + endocrine cells and also expressed NKX6.1 and NKX2.2. In addition, pancreatic β- cells expressing insulin and polyhormonal cells expressing both insulin and glucagon were obtained at the final stage of pancreatic differentiation. In conclusion, our data suggest that an optimal topographical structure for differentiation to specific cell types from hPSCs can be tested efficiently by using gradient-pattern chips designed with varying sizes and surfaces.</P> <P><B>Statement of Significance</B></P> <P>Our study provides demonstrates of using gradient nanopatterned chips for differentiation of pancreatic islet-like clusters.</P> <P>Gradient nanopatterned chips are consisted of two different shapes (nanopillar and nanopore) in three different ranges of nano sizes (100–200, 200–300, 300–400 nm). We found that optimal nanostructures for differentiation of pancreatic islet-like clusters were 200–300 nm nano pores.</P> <P>Cell transplantation is one of the major therapeutic option for type 1 diabetes mellitus (DM) using stem cell-derived β-like cells. We generated 50 um pancreatic islet-like clusters in size, which would be an optimal size for cell transplantation. Futuremore, the small clusters provide a powerful source for cell therapy.</P> <P>Our findings suggest gradient nanopatterned chip provides a powerful tool to generate specific functional cell types of a high purity for potential uses in cell therapy development.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Dae-Seung,Lee, Hyun-Ja,Jeon, Yong-Deok,Han, Yo-Han,Kee, Ji-Ye,Kim, Hyun-Jeong,Shin, Hyun-Ji,Kang, JongWook,Lee, Beom Su,Kim, Sung-Hoon,Kim, Su-Jin,Park, Sang-Hyun,Choi, Byung-Min,Park, Sung-Joo,U Institute for Advanced Research in Asian Science a 2015 The American journal of Chinese medicine Vol.43 No.4
<P>In this study, we found that alpha-pinene (α-pinene) exhibits anti-inflammatory activity through the suppression of mitogen-activated protein kinases (MAPKs) and the nuclear factor-kappa B (NF-κB) pathway in mouse peritoneal macrophages. α-Pinene is found in the oils of many coniferous trees and rosemary. We investigated the inhibitory effects of α-Pinene on inflammatory responses induced by lipopolysaccharide (LPS) using mouse peritoneal macrophages. α-Pinene significantly decreased the LPS-induced production of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and nitric oxide (NO). α-Pinene also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expressions in LPS-stimulated macrophages. Additionally, the activations of MAPKs and NF-κB were attenuated by means of α-pinene treatment. These results indicate that α-pinene has an anti-inflammatory effect and that it is a potential candidate as a new drug to treat various inflammatory diseases.</P>
Kim, Kee-Young,Osabutey, Angelina F.,Nguyen, Phuong,Kim, Soo Bae,Jo, You-Young,Kweon, HaeYong,Lee, Hyun-Tai,Ji, Sang-Deok,Koh, Young Ho Korean Society of Sericultural Science 2019 International Journal of Industrial Entomology Vol.39 No.1
Steamed and freeze-dried mature silkworm powder (SMSP) is a natural food containing a large amount of various functional materials and has various health promoting effects. SMSP is known to increase the life expectancy and healthspan, simultaneously. The accomplishment of extension of healthspan should be possible to achieve by activating various signaling pathways delaying aging in various tissues, not by regulating only a few signaling pathways. Consistent with this notion, SMSP increased the resistant to Parkinson disease by enhancing olfaction and mitochondrial activity in neurons of animal models. In addition, SMSP could enhance the gastrointestinal functions. The animals consumed SMSP showed enhanced alcohol metabolisms, reduced cholesterols in bloods, increased resistance to carcinogens causing liver cancers, and protective effects in alcohol induced stomach ulcers. Furthermore, SMSP was also effective in appearance. The SMSP consumed animals showed reduced skin pigmentations and more hair growth compared with control animals. Taken together, the functional enhancement effects of SMSPs in various tissues and organs, which have been discovered to date, are combined to extend healthspan. Therefore, SMSP can be regarded as calorie restriction mimetics. Further studies in the health promoting effects of SMSP will contribute to identifying new applicable diseases, resulted in increased sales of SMSP and incomes of sericulture farmers.
Kim, Hyun-Soo,Sim, Eun Deok,Kim, Jong-hoi,Kwon, Oh Kee,Kim, Kang Ho,Oh, Kwang-Ryong Institute of Physics 2006 Semiconductor science and technology Vol.21 No.10
<P>All-optical wavelength conversion at 10 Gb s<SUP>−1</SUP> is demonstrated in a Mach–Zehnder interferometric wavelength converter (MZI-WC) module with monolithically integrated SOA preamplifiers and tapered-edge multimode interference couplers (TMMIs). A conventional buried-type 1 × 2 MMI coupler exhibits a minimal excess loss of 0.43 dB and a reflectivity of 5.1 × 10<SUP>−4</SUP> (<I>L</I><SUB>MMI</SUB> = 172 µm, <I>W</I><SUB>MMI</SUB> = 12 µm). We adapt the 1 × 2 TMMI in the MZI-WC to improve back-reflection and poor uniformity, which is a major problem of conventional MMI and Y-branch. A good performance of the MZI-WC monolithically integrated with TMMI and SOA preamplifiers at 10 Gb s<SUP>−1</SUP> is obtained with clear eye patterns, and a power penalty below 1.5 dB at a 10<SUP>−9</SUP> bit error rate over the whole C band (45 nm span) is obtained. The dynamic input power range is enhanced up to 11.3 dB by adjusting only the injection current of the SOA preamplifier.</P>
Inflammatory Fibroid Polyp of the Stomach Mimicking Gastric Cancer
Kee Hwan Kim(김기환),Hak Jun Seo(서학준),Ji Il Kim(김지일),Chang Hyeok Ahn(안창혁),Jeong Soo Kim(김정수),Young Mi Ku(구영미),Ok Ran Shin(신옥란),Eun Deok Chang(장은덕),Eun Jung Lee(이은정),Keun Woo Lim(임근우) 대한외과학회 2003 Annals of Surgical Treatment and Research Vol.65 No.1
Microsatellite Analysis of the Silkworm Strains (Bombyx mori) Originated from China
( Kee Young Ki ),( Pil Don Kang ),( Kang Sun Ryu ),( Ki Hwan Kim ),( Gyoo Byung Sung ),( Sang Deok Ji ),( Mi Ja Kim ),( Iksoo Kim ) 한국잠사학회 2012 International Journal of Industrial Entomology Vol.25 No.1
A total of 85 Chinese-origin silkworm strains preserved in Korea were genotyped for eight polymorphic microsatellite loci. We obtained per-locus number of alleles, ranging from 5 to 14 with an average value of 9.5, perlocus observed heterozygosity, ranging from 0.07 to 0.99, and per-locus polymorphic information content PIC), ranging from 0.34 to 0.82, indicating that some loci are highly variable. Phylogenetic analysis with the eight concatenated microsatellite loci showed no clustering on the basis of known strain characteristics. A total of 22 strain-specific apomorphic alleles, which discriminate 19 among 85 silkworm strains were obtained from eight loci. These strain-specific alleles, thus, can casually be utilized for the discrimination of applicable strains without any further typing of other loci. Furthermore, a substantial number of homozygote strains, represented by 27 among 76 alleles in eight loci were found. These results collectively suggest that the silkworm microsatellite DNA is actually and potentially important molecular markers for the eventual discrimination of silkworm strains that are preserved as hundreds in Korea.
Kim, Ji-Seong,Lee, Young-Su,Kim, Sung-Kee,Kim, Ki-Deok,Kim, Jin-Won The Korean Society of Plant Pathology 2011 Plant Pathology Journal Vol.27 No.2
During the summer of 2005, specimens of soybean cultivars (Daepung, Daewon, Hwanggeum and Taegwang) showing frogeye leaf spot (FLS) were obtained from various areas in Korea. Eight isolates identified as Cercospora sojina were inoculated on the adaxial leaf surfaces of 63 Korean soybean cultivars; the disease responses to each isolate were evaluated 14 days and 21 days after inoculation. Based on the disease responses (resistant or susceptible) of the cultivars by the isolates, a set of cultivars (Anpeong, Bogwang, Cheongdu No. 1, Cheongja No. 3, Dachae, Daemang, Jangwon, Namhae, Sowon, Taegwang) were selected and inoculated with seven isolates for further testing pathogenic variance. Interestingly, 6 out of 7 tested C. sojina isolates revealed differential ability in infecting different soybean cultivars. This result may indicate the possibility of new race occurrence or pathogenic variation; this also presents evidence for prevalent FLS occurrence during humid and hot weather in Korea.
Microsatellite Analysis of the Silkworm Strains (Bombyx mori) Originated from China
Kim, Kee-Young,Kang, Pil-Don,Ryu, Kang-Sun,Kim, Ki-Hwan,Sung, Gyoo-Byung,Ji, Sang-Deok,Kim, Mi-Ja,Kim, Ik-Soo Korean Society of Sericultural Science 2012 International Journal of Industrial Entomology Vol.25 No.1
A total of 85 Chinese-origin silkworm strains preserved in Korea were genotyped for eight polymorphic micro-satellite loci. We obtained per-locus number of alleles, ranging from 5 to 14 with an average value of 9.5, perlocus observed heterozygosity, ranging from 0.07 to 0.99, and per-locus polymorphic information content (PIC), ranging from 0.34 to 0.82, indicating that some loci are highly variable. Phylogenetic analysis with the eight concatenated microsatellite loci showed no clustering on the basis of known strain characteristics. A total of 22 strain-specific apomorphic alleles, which discriminate 19 among 85 silkworm strains were obtained from eight loci. These strain-specific alleles, thus, can casually be utilized for the discrimination of applicable strains without any further typing of other loci. Furthermore, a substantial number of homozygote strains, represented by 27 among 76 alleles in eight loci were found. These results collectively suggest that the silkworm microsatellite DNA is actually and potentially important molecular markers for the eventual discrimination of silkworm strains that are preserved as hundreds in Korea.