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- 저자 : Dengke Zhang (검색결과 4 건)
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Management Strategy Based on Genetic Algorithm Optimization for PHEV
Zhang Yu,Meng Dawei,Zhou Meilan,Lu Dengke 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.11
Aiming at the refitted HAFEI hybrid electric vehicle (HEV), fuzzy logic energy management strategy is constructed based on genetic algorithm optimization. The difference value D between the total require torque Tr of path and the target required torque Te of engine, the intelligence quotient value with Tr is selected as the first input variable of fuzzy controller, the SOC of battery as the second input variable; torque control coefficient C is selected as output variable, meanwhile two input variable membership function is improved on genetic algorithm. To further evaluate the control strategy, dynamic programming control strategy is used as standard; the simulation experiments show that every kind of gas emission is obviously reduced by 12% to 47% in fuzzy control strategy B based on genetic algorithm optimization compared to strategy A based on determinacy rules. Compared to dynamic programming, fuel economy in strategy A is only 45.09% of standard value which is not ideal, the utilization of fuel is low and the gas emission is serious, while in strategy B fuel economy is 78.89% of standard value and effect is improved obviously.
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Shafiq, Muhammad,Zhang, Qiuying,Zhi, Dengke,Wang, Kai,Kong, Deling,Kim, Dong-Hwee,Kim, Soo Hyun Lippincott WilliamsWilkins 2018 Arteriosclerosis, thrombosis, and vascular biology Vol.38 No.7
<▼1><P>Supplemental Digital Content is available in the text.</P></▼1><▼2><P><B>Objective—</B></P><P>The objective of this study was to develop small-diameter vascular grafts capable of eluting SDF (stromal cell–derived factor)-1α–derived peptide and SP (substance P) for in situ vascular regeneration.</P><P><B>Approach and Results—</B></P><P>Polycaprolactone (PCL)/collagen grafts containing SP or SDF-1α–derived peptide were fabricated by electrospinning. SP and SDF-1α peptide-loaded grafts recruited significantly higher numbers of mesenchymal stem cells than that of the control group. The in vivo potential of PCL/collagen, SDF-1, and SP grafts was assessed by implanting them in a rat abdominal aorta for up to 4 weeks. All grafts remained patent as observed using color Doppler and stereomicroscope. Host cells infiltrated into the graft wall and the neointima was formed in peptides-eluting grafts. The lumen of the SP grafts was covered by the endothelial cells with cobblestone-like morphology, which were elongated in the direction of the blood flow, as discerned using scanning electron microscopy. Moreover, SDF-1α and SP grafts led to the formation of a confluent endothelium as evaluated using immunofluorescence staining with von Willebrand factor antibody. SP and SDF-1α grafts also promoted smooth muscle cell regeneration, endogenous stem cell recruitment, and blood vessel formation, which was the most prominent in the SP grafts. Evaluation of inflammatory response showed that 3 groups did not significantly differ in terms of the numbers of proinflammatory macrophages, whereas SP grafts showed significantly higher numbers of proremodeling macrophages than that of the control and SDF-1α grafts.</P><P><B>Conclusions—</B></P><P>SDF-1α and SP grafts can be potential candidates for in situ vascular regeneration and are worthy for future investigations.</P></▼2>
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Huawei Li,Jifei Yang,Dengke Bao,Jie Hou,Yubao Zhi,Yanyan Yang,Pengchao Ji,Enmin Zhou,Songlin Qiao,Gaiping Zhang 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.3
A simple and rapid immunochromatographic test strip incorporating a colloidal gold-labeled recombinant Nsp7 antigen probe was successfully developed for the detection of anti-porcine reproductive and respiratory syndrome virus (PRRSV) antibodies in swine. Recombinant Nsp7 protein of PRRSV labeled with colloidal gold was dispensed on a conjugate pad for use as the detector. Staphylococcal protein A and purified porcine anti-Nsp7 antibodies were blotted on a nitrocellulose membrane to form test and control lines, respectively. A comparison of the strip with standard diagnostic tests, enzyme-linked immunosorbent assays and immunoperoxidase monolayer assay, was also performed. The immunochromatographic test strip was shown to be of high specificity and sensitivity. Furthermore, the strip assay is rapid and easy to perform with no requirement for professional-level skills or equipment. It is suggested that the immunochromatographic test strip can be used to quickly and accurately detect PRRSV antibody and to be suitable for diagnostic purposes in the field.
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MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
Yang Yang,Rongfang Qiu,Qiaoyou Weng,Ziwei Xu,Jingjing Song,Siyu Zhao,Miaomiao Meng,Dengke Zhang,Chunli Kong,Hailin Wang,Min Xu,Zhongwei Zhao,Jiansong Ji 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose Mixed-lineage leukemia protein 4 (MLL4/KMT2D) is a histone methyltransferase, and its mutation has been reported to be associated with a poor prognosis in many cancers, including lung cancer. We investigated the function of MLL4 in lung carcinogenesis. Materials and Methods RNA sequencing (RNA-seq) in A549 cells transfected with control siRNA or MLL4 siRNA was performed. Also, we used EdU incorporation assay, colony formation assays, growth curve analysis, transwell invasion assays, immunohistochemical staining, and in vivo bioluminescence assay to investigate the function of MLL4 in lung carcinogenesis. Results We found that MLL4 expression was downregulated in non–small cell lung cancer (NSCLC) tissues compared to adjacent normal tissues and tended to decrease with disease stage progression. We analyzed the transcriptomes in control and MLL4- deficient cells using high-throughput RNA deep sequencing (RNA-seq) and identified a cohort of target genes, such as SOX2, ATF1, FOXP4, PIK3IP1, SIRT4, TENT5B, and LFNG, some of which are related to proliferation and metastasis. Our results showed that low expression of MLL4 promotes NSCLC cell proliferation and metastasis and is required for the maintenance of NSCLC stem cell properties. Conclusion Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for NSCLC therapy.
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