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Han, Jae Hyun,Kwak, Jun-Hyuk,Joe, Daniel Juhyung,Hong, Seong Kwang,Wang, Hee Seung,Park, Jung Hwan,Hur, Shin,Lee, Keon Jae unknown 2018 Nano energy Vol.53 No.-
<P><B>Abstract</B></P> <P>Herein, we report a self-powered flexible piezoelectric acoustic sensor (f-PAS) inspired by basilar membrane in human cochlear. The f-PAS covered the voice frequency spectrum via the combination of its low quality (Q) factor and multi-resonant frequency tuning, exhibiting four to eight times higher sensitivity than the conventional condenser sensor. Our piezoelectric acoustic sensor with a thin membrane design produced sufficient output voltages by the distinct resonant movement of the Pb[Zr<SUB>0.52</SUB>Ti<SUB>0.48</SUB>]O<SUB>3</SUB> (PZT) membrane under the minute acoustic sound stimuli. Multiple sensor channels were integrated in a single f-PAS chip with a size of 1.5 × 3 cm<SUP>2</SUP>, which acquire multi-tunable piezoelectric signals without any external power. A linear response of the resonance frequency of the curved piezoelectric membrane was theoretically investigated by a finite element method (FEM) calculation. Low Q factors from corresponding channels were achieved by optimal membrane thickness and channel length.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Self-powered flexible piezoelectric acoustic sensor (f-PAS) was inspired by basilar membrane. </LI> <LI> Multi-channel f-PAS provided abundant voice information from speech without external power. </LI> <LI> A linear response in the resonance frequency of the curved PZT membrane was achieved. </LI> <LI> Coverage of the voice frequency range from 100 to 4000 Hz in f-PAS was realized. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Case Reports : Development of Dermatomyofibroma in a Male Infant
( Ji Hyun Sim ),( Jae Young Shin ),( Daniel P. Vandersteen ),( You Chan Kim ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1S
Dermatomyofibroma is a rare benign cutaneous mesenchymal neoplasm of the fibroblasts and myofibroblasts. The majority of dermatomyofibromas present as red-brown discolored plaques or nodules, commonly located on the shoulder, upper arm, axilla, neck, and/or upper trunk. These lesions develop most frequently in young female patients at a mean of 28-years-of-age. Herein, a case of dermatomyofibroma is reported that developed in an infant. A 4-month-old boy presented with an ill-defined bluish firm plaque on the trunk that developed 1 month after birth. Histopathologically, there was proliferation of bland-looking spindle cells with fascicular arrangement in the dermis and subcutaneous tissue. Immunohistochemistry showed that most of the tumor cells expressed diffuse positivity for vimentin and smooth muscle actin, but were negative for S-100 protein, desmin, and CD34. (Ann Dermatol 23(S1) S72~S74, 2011)
Machine learning-based self-powered acoustic sensor for speaker recognition
Han, Jae Hyun,Bae, Kang Min,Hong, Seong Kwang,Park, Hyunsin,Kwak, Jun-Hyuk,Wang, Hee Seung,Joe, Daniel Juhyung,Park, Jung Hwan,Jung, Young Hoon,Hur, Shin,Yoo, Chang D.,Lee, Keon Jae Elsevier 2018 Nano energy Vol.53 No.-
<P><B>Abstract</B></P> <P>Herein, we report a new platform of machine learning-based speaker recognition via the flexible piezoelectric acoustic sensor (f-PAS) with a highly sensitive multi-resonant frequency band. The resonant self-powered f-PAS was fabricated by mimicking the operating mechanism of the basilar membrane in the human cochlear. The f-PAS acquired abundant voice information from the multi-channel sound inputs. The standard TIDIGITS dataset were recorded by the f-PAS and converted to frequency components by using a Fast Fourier Transform (FFT) and a Short-Time Fourier Transform (STFT). The machine learning based Gaussian Mixture Model (GMM) was designed by utilizing the most highest and second highest sensitivity data among multi-channel outputs, exhibiting outstanding speaker recognition rate of 97.5% with error rate reduction of 75% compared to that of the reference MEMS microphone.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A new platform of machine learning-based speaker recognition system was realized. </LI> <LI> The resonant self-powered f-PAS was fabricated by mimicking the human cochlear. </LI> <LI> Using the machine learning algorithm, f-PAS exhibited high speaker recognition rate. </LI> </UL> </P>
Feasibility of Bilateral Crossing C7 Intralaminar Screws : A Cadaveric Study
Baek, Tae-Hyun,Kim, Ilsup,Hong, Jae-Taek,Kim, Daniel H.,Shin, Dongsuk,Lee, Sang-Won The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.56 No.1
Objective : When the pedicle screw insertion technique is failed or not applicable, C7 intralaminar screw insertion method has been used as an alternative or salvage fixation method recently. However, profound understanding of anatomy is required for safe application of the bilaterally crossing laminar screw at C7 in clinic. In this cadaveric study, we evaluated the anatomic feasibility of the bilateral crossing intralaminar screw insertion and especially focused on determination of proper screw entry point. Methods : The C7 vertebrae from 18 adult specimens were studied. Morphometric measurements of the mid-laminar height, the minimum laminar thickness, the maximal screw length, and spino-laminar angle were performed and cross-sectioned vertically at the screw entry point (spino-laminar junction). The sectioned surface was equally divided into 3 parts and maximal thickness and surface area of the parts were measured. All measurements were obtained bilaterally. Results : The mean mid-laminar height was 13.7 mm, mean minimal laminar thickness was 6.6 mm, mean maximal screw length was 24.6 mm, and mean spinolaminar angle was $50.8{\pm}4.7^{\circ}$. Based on the measured laminar thickness, the feasibility of 3.5 mm diameter intralaminar screw application was 83.3% (30 sides laminae out of total 36) when assuming a tolerance of 1 mm on each side. Cross-sectional measurement results showed that the mean maximal thickness of upper, middle, and lower thirds was 5.0 mm, 7.5 mm, and 7.3 mm, respectively, and mean surface area for each part was $21.2mm^2$, $46.8mm^2$, and $34.7mm^2$, respectively. Fourteen (38.9%) sides of laminae would be feasible for 3.5 mm intralaminar screw insertion when upper thirds of C7 spino-laminar junction is the screw entry point. In case of middle and lower thirds of C7 spino-laminar junction, 32 (88.9%) and 28 (77.8%) sides of laminae were feasible for 3.5 mm screw insertion, respectively. Conclusion : The vertical cross-sectioned area of middle thirds at C7 spinolaminar junction was the largest area and 3.5 mm screw can be accommodated with 77.8 % of feasibility when lower thirds were the screw entry point. Thus, selection of middle and lower thirds for each side of screw entry point in spino-laminar junction would be the safest way to place bilateral crossing laminar screw within the entire lamina. This anatomic study result will help surgeons to place the screw safely and accurately.
Thomas, Courtney R.,Ferris, Daniel P.,Lee, Jae-Hyun,Choi, Eunjoo,Cho, Mi Hyeon,Kim, Eun Sook,Stoddart, J. Fraser,Shin, Jeon-Soo,Cheon, Jinwoo,Zink, Jeffrey I. American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.31
<P>Mesoporous silica nanoparticles are useful nanomaterials that have demonstrated the ability to contain and release cargos with mediation by gatekeepers. Magnetic nanocrystals have the ability to exhibit hyperthermic effects when placed in an oscillating magnetic field. In a system combining these two materials and a thermally sensitive gatekeeper, a unique drug delivery system can be produced. A novel material that incorporates zinc-doped iron oxide nanocrystals within a mesoporous silica framework that has been surface-modified with pseudorotaxanes is described. Upon application of an AC magnetic field, the nanocrystals generate local internal heating, causing the molecular machines to disassemble and allowing the cargos (drugs) to be released. When breast cancer cells (MDA-MB-231) were treated with doxorubicin-loaded particles and exposed to an AC field, cell death occurred. This material promises to be a noninvasive, externally controlled drug delivery system with cancer-killing properties.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-31/ja1022267/production/images/medium/ja-2010-022267_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja1022267'>ACS Electronic Supporting Info</A></P>
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy
Lee, Jin-Ku,Liu, Zhaoqi,Sa, Jason K.,Shin, Sang,Wang, Jiguang,Bordyuh, Mykola,Cho, Hee Jin,Elliott, Oliver,Chu, Timothy,Choi, Seung Won,Rosenbloom, Daniel I. S.,Lee, In-Hee,Shin, Yong Jae,Kang, Hyun J Nature Pub. Co 2018 Nature genetics Vol.50 No.10