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RISS 인기검색어
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- 저자 : Dandan Cao (검색결과 5 건)
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KRAB family is involved in network shifts in response to osmotic stress in camels
Dandan Cao,Shenyuan Wang,Dong Zhang,Yanru Zhang,Junwei Cao,Yongbin Liu,Huanmin Zhou 한국통합생물학회 2022 Animal cells and systems Vol.26 No.6
A feature of the camel is its tolerance to osmotic stress. However, few studies of osmotic stress in vivo or comparative analyses between different tissues of the camel have been performed. Here, we report the roles of Krüppel-associated box domain containing zinc-finger repressor proteins (KRAB-ZFPs) in transcriptional networks under osmotic stress in camels by analyzing transcriptomes of four different tissues under various osmotic conditions. We found that 273 of 278 KRAB-ZFPs were expressed in our data set, being involved in all of the 65 identified networks and exhibiting their extensive functional diversity. We also found that 110 KRAB-ZFPs were hub genes involved in more than half of the networks. We demonstrated that the osmotic stress response is involved in network shifts and that KRAB-ZFPs mediate this process. Finally, we presented the diverse mechanisms of osmotic stress responses in different tissues. These results revealed the genetic architecture of systematic physiological response in vivo to osmotic stress in camels. Our work will lead to new directions for studying the mechanism of osmotic stress response in anti-arid mammals.
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Lipid-coated ZnO nanoparticles synthesis, characterization and cytotoxicity studies in cancer cell
Cao Dingding,Shu Xugang,Zhu Dandan,Liang Shengli,Hasan Murtaza,Gong Sheng 나노기술연구협의회 2020 Nano Convergence Vol.7 No.14
ZnO nanoparticles are widely used in biological, chemical, and medical fields, but their toxicity impedes their wide application. In this study, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) and lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) with different morphologies were prepared by chemical method and characterized by TEM, XRD, HRTEM, FTIR, and DLS. Our results showed that the lipid-coated ZnO NPs (~ 13 nm; ~ 22 nm; ~ 52 nm) groups improved the colloidal stability, prevented the aggregation and dissolution of nanocrystal particles in the solution, inhibited the dissolution of ZnO NPs into Zn 2+ cations, and reduced cytotoxicity more efficiently than the pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm). Compared to the lipid-coated ZnO NPs, pristine ZnO NPs (~ 7 nm; ~ 18 nm; ~ 49 nm) could dose-dependently destroy the cells at low concentrations. At the same concentration, ZnO NPs (~ 7 nm) exhibited the highest cytotoxicity. These results could provide a basis for the toxicological study of the nanoparticles and direct future investigations for preventing strong aggregation, reducing the toxic effects of lipid-bilayer and promoting the uptake of nanoparticles by HeLa cells efficiently.
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The Application of CCD Pixel Positioning Subdivision in the Reach of Laser Triangulation Measurement
Miao Cao,Dandan Wang 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.1
During laser triangulation measurement, CCD image sensor is used to detect the laser spot with the measured information. Resolution and pixel size of CCD, directly affect the precision of laser scanning measurement. Based on the analysis of the gray centroid algorithm, the improvement gray centroid algorithm is proposed. By using the algorithm to solve the CCD location subdivision, the corresponding relationship between the spot position and the pixel is confirmed. The realization of the acquisition enhances the resolution through the segmentation, and the accuracy of laser triangulation measurement is improved.
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( Bin Zhong ),( Zhongshan Zhang ),( Dandan Zhang ),( Keping Long ),( Haiyan Cao ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.11
The performance of an partial relay selection on the decode-and-forward (DF) mode cognitive radio (CR) relay networks is studied, with some important factors, including the outage probability, the bit error ratio (BER), and the average channel capacity being analyzed. Different from the conventional relay selection schemes, the impact of spectrum sensing process as well as the spectrum utilization efficiency of primary users on the performance of DF-based CR relaying networks has been taken into consideration. In particular, the exact closed-form expressions for the figures of merit such as outage probability, BER, and average channel capacity over independent and identically distributed (i.i.d.) Rayleigh fading channels, have been derived in this paper. The validity of the proposed analysis is proven by simulation, which showed that the numerical results are consistent with the theoretical analysis in terms of the outage probability, the BER and the average channel capacity. It is also shown that the full spatial diversity order can always be obtained at the signal-to-noise ratio (SNR) range of [0dB, 15dB] in the presence of multiple potential relays.
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Yuan Donglan,Zhu Dandan,Yin Boyu,Ge Hongshan,Zhao Yinling,Huang Aihua,Wang Xiaosu,Cao Xiuhong,Xia Nan,Qian Hua 한국유전학회 2022 Genes & Genomics Vol.44 No.5
Background: Endometriosis (EM) is a gynecological disease that poses severe health risks to women, although its pathogenesis has yet to be fully elucidated. It has been shown that long non-coding RNAs (lncRNAs) are closely associated with EM initiation and have a role in the development of this disease. Previous studies exploring the expression of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) have shown that this lncRNA functions as a tumor promoter in endometrial cancer. However, its exact mechanism of action in EM remains unclear. Objective: This report was designed to illustrate the potential molecular mechanisms of lncRNA NEAT1 on EM. Methods: Endometrial tissues were extracted from EM model rats and patients with EM. Hematoxylin and eosin staining was applied to detect the morphological changes that occurred in rats after construction of the model. Endometrial stromal cells (ESCs) were extracted from either ectopic endometrium (EC) or eutopic endometrium (EU) tissues from patients with EM. LncRNA NEAT1 and miR-124-3p expression in EM tissues and cells were subsequently evaluated by reverse transcription-quantitative (RT-q)PCR analysis. MTT assay, flow cytometric analysis, western blot assay and Transwell assay were then employed to examine the effect of NEAT1 and miR-124-3p on EC-ESC proliferation, apoptosis, migration and invasion, respectively. The targeted relationship between lncRNA NEAT1 and miR-124-3p was subsequently confirmed by dual-luciferase and co-transfection assays. Results: MiR-124-3p was identified as a target of NEAT1, and could be negatively regulated by NEAT1 in EC-ESCs. The expression level of NEAT1 was evidently increased, whereas that of miR-124-3p was decreased, in the EM in vivo model, EM tissues and EC-ESCs from patients with EM. The loss-of-function assays further established that silencing of NEAT1 could inhibit EC-ESC proliferation, migration, and invasion, but it led to the promotion of apoptosis via targeting miR-124-3p. Conclusions: NEAT1 is significantly upregulated in EM, promoting malignant behavior in EM through targeting miR-124-3p expression.
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