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- 저자 : Da Young Yu (검색결과 164 건)
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곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung1),유일재(Il Je Yu1),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.2
3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no<br/> effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.
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Yu, Da-Young,Yu, Young-Dong,Kim, Wan-Bae,Han, Hyung-Joon,Choi, Sae-Byul,Kim, Dong-Sik,Choi, Sang-Yong,Kim, Joo-Young,Chang, Hyeyoon,Kim, Baek-Hui The Korean Surgical Society 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.5
<P><B>Purpose</B></P><P>Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent.</P><P><B>Methods</B></P><P>We retrospectively reviewed the clinicopathologic data of patients who underwent pancreatectomy for PDAC from January 2002 to January 2013. Intraductal papillary mucinous lesions and mucinous cystic neoplasms were excluded. All available postoperative imaging and clinical follow-up data were reviewed.</P><P><B>Results</B></P><P>There were 95 patients who underwent pancreatectomy. Tumors were most commonly located in the pancreas head and as such pancreaticoduodenectomy was the most commonly performed operation. The median tumor size was 3.2 cm. An absence of PanIN lesions was identified in 39 patients (41%). Of the patients with PanIN lesions, high-grade PanIN (grade 3) was the most common type (64.3%) followed by grade 2 (28.6%). There was no significant difference in overall survival or disease-free survival between the non-PanIN and PanIN groups.</P><P><B>Conclusion</B></P><P>The presence or absence of PanIN lesions did not affect survival in patients undergoing resection for pancreatic cancer. However, patients with high-grade PanINs tended to have better overall survival. Larger studies with longer follow up are needed to accurately determine its clinical significance.</P>
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Da-Young Yu,Young-Dong Yu,Wan-Bae Kim,Hyung-Joon Han,Sae-Byul Choi,Dong-Sik Kim,Sang-Yong Choi,Joo-Young Kim,Hyeyoon Chang,Baek-Hui Kim 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.5
Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent. Methods: We retrospectively reviewed the clinicopathologic data of patients who underwent pancreatectomy for PDAC from January 2002 to January 2013. Intraductal papillary mucinous lesions and mucinous cystic neoplasms were excluded. All available postoperative imaging and clinical follow-up data were reviewed. Results: There were 95 patients who underwent pancreatectomy. Tumors were most commonly located in the pancreas head and as such pancreaticoduodenectomy was the most commonly performed operation. The median tumor size was 3.2 ㎝. An absence of PanIN lesions was identified in 39 patients (41%). Of the patients with PanIN lesions, high-grade PanIN (grade 3) was the most common type (64.3%) followed by grade 2 (28.6%). There was no significant difference in overall survival or disease-free survival between the non-PanIN and PanIN groups. Conclusion: The presence or absence of PanIN lesions did not affect survival in patients undergoing resection for pancreatic cancer. However, patients with high-grade PanINs tended to have better overall survival. Larger studies with longer follow up are needed to accurately determine its clinical significance.
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Yu, Da Young,Noh, Soo Min,Lee, Gyun Min Elsevier 2016 Journal of biotechnology Vol.231 No.-
<P>To investigate the feasibility of glutamine synthetase (GS)-mediated gene amplification in HEK293 cells for the high-level stable production of therapeutic proteins, HEK293E cells were transfected by the GS expression vector containing antibody genes and were selected at various methionine sulfoximine (MSX) concentrations in 96-well plates. For a comparison, CHOK1 cells were transfected by the same GS expression vector and selected at various MSX concentrations. Unlike CHOK1 cells, HEK293E cells producing high levels of antibodies were not selected at all. For HEK293E cells, the number of wells with the cell pool did not decrease with an increase in the concentration of MSX up to 500 OA MSX. A q-RT-PCR analysis confirmed that the antibody genes in the HEK293E cells, unlike the CHOK1 cells, were not amplified after increasing the MSX concentration. It was found that the GS activity in HEK293E cells was much higher than that in CHOK1 cells (P < 0.05). In a glutamine-free medium, the GS activity of HEK293E cells was approximately 4.8 times higher than that in CHOK1 cells. Accordingly, it is inferred that high GS activity of HEK293E cells results in elevated resistance to MSX and therefore hampers GS-mediated gene amplification by MSX. Thus, in order to apply the GS-mediated gene amplification system to HEK293 cells, the endogenous GS expression level in HEK293 cells needs to be minimized by knock-out or down-regulation methods. (C) 2016 Elsevier B.V. All rights reserved.</P>
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Da Hyun Jung,Young Hoon Youn,Hye Kyung Jung,Seung Young Kim,Cheal Wung Huh,Cheol Min Shin,Jung-Hwan Oh,Kyu Chan Huh,Moo In Park,Suck Chei Choi,Ki Bae Kim,Seon-Young Park,Joong Goo Kwon,Yu Kyung Cho,Ju 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4
Background/AimsIt remains unclear which maintenance treatment modality is most appropriate for mild gastroesophageal reflux disease (GERD). We aimed to compare on-demand treatment with continuous treatment using a proton pump inhibitor (PPI) in the maintenance treatment for patients with non-erosive GERD or mild erosive esophagitis. MethodsPatients whose GERD symptoms improved after 4 weeks of standard dose PPI treatment were prospectively enrolled at 25 hospitals. Subsequently, the enrolled patients were randomly assigned to either an on-demand or a continuous maintenance treatment group, and followed in an 8-week interval for up to 24 weeks. ResultsA total of 304 patients were randomized to maintenance treatment (continuous, n = 151 vs on-demand, n = 153). The primary outcome, the overall proportion of unwillingness to continue the assigned maintenance treatment modality, failed to confirm the non-inferiority of on-demand treatment (45.9%) compared to continuous treatment (36.1%). Compared with the on-demand group, the GERD symptom and health-related quality of life scores significantly more improved and the overall satisfaction score was significantly higher in the continuous treatment group, particularly at week 8 and week 16 of maintenance treatment. Work impairment scores were not different in the 2 groups, but the prescription cost was less in the on-demand group. Serum gastrin levels significantly elevated in the continuous treatment group, but not in the on-demand group. ConclusionsContinuous treatment seems to be more appropriate for the initial maintenance treatment of non-erosive GERD or mild erosive esophagitis than on-demand treatment. Stepping down to on-demand treatment needs to be considered after a sufficient period of continuous treatment.
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초등 영어 검인정 교과서 CD-ROM타이틀 평가 준거 개발
유다영(Yu, Da-young) 한국초등영어교육학회 2013 초등영어교육 Vol.19 No.2
The purpose of this study is to develop criteria for evaluating English CD-ROM title for elementary school. For this purpose, 2008 revised version of Elementary English curriculum, criteria for evaluating multimedia materials already developed were analyzed, and surveys for teachers and students in elementary school were carried out. Through this procedure, the evaluation criteria for elementary English government-authorized CD-ROM title were developed and applied to four different type of elementary English government-authorized CD-ROM titles for verification. The findings and implications of the research are as follows: first, the importance of selecting a elementary English government-authorized CD-ROM title should be recognized by teachers in elementary schools considering a great amount of time of usage in each English class. Second, it should be suggested that further studies in evaluation criteria for elementary English governmentauthorized CD-ROM titles should be needed. In reality, many elementary school teachers choose CD-ROM titles by unsystematic ways, not to mention that they don’t know that there are evaluation criteria already developed for choosing multimedia materials. Lastly, the use of the evaluation criteria should be at each school’s discretion. Schools are under different circumstances, and the characteristics of students in each school are not the same. Therefore, it will be desirable for each school to think of this evaluation criteria as one example and know that they can modify them to meet their needs.
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유다미 ( Yu Da-mi ),김혜인 ( Kim Hye-in ),박진원 ( Park Jin-won ),이사랑 ( Lee Sa-rang ),하효정 ( Ha Hyo-jung ),윤재영 ( Yun Ray Jae-young ) 커뮤니케이션디자인학회 2016 커뮤니케이션 디자인학연구 Vol.57 No.-
우리나라는 이미 2000년에 고령화사회에 접어 들었고 2026년에는 초고령사회로 접어들 것으로 예상된다. 늘어나는 노인의 수 만큼이나 독거노인과 그 문제가 심각해지고 있지만 그에 대한 지원 및 관리는 매우 부족한 실정이다. 본 연구는 이러한 문제를 해소하기 위해 독거노인의 증가에 따라 발생되는 문제를 알아보고 그 해결방안으로 봉사와 기부에 상대적으로 호의적인 청년(학생)층을 유입할 수 있는 서비스 디자인을 제안한다. 연구방법으로는 관찰조사를 통하여 독거노인, 청년(학생), 어르신 돌봄 센터와 같은 이해관계자를 도출하고, 설문조사 및 심층 인터뷰 통하여 각 이해 관계자 간에 발생하는 문제점을 발견하였다. 문제점을 해소하기 위해 크게 `봉사하기`, `기부하기` 기능으로 나누어 신청단계를 간소화하였다. 또한 시간기부인 봉사를 통해 획득한 `베리` 포인트는 물질적으로 지정기부를 할 수 있도록 기획하였다. 이와 같은 기능들을 모바일앱 프로토타입으로 제작 하였고 1차, 2차에 걸친 사용성 테스트를 진행했다. 결과적으로 본 연구가 독거노인 문제 해소와 청년들을 대상으로 한 새로운 기부문화 창출에 기여할 것으로 기대한다. Korea already became a fast aging society in 2000 and there is a forecast of becoming a super-aged society by 2026. As the number of the aged increases, the issue related with the increasing number of elderly people living alone and aging society is becoming more serious but there is an insufficiency in supporting senior citizens and managing the situation. The purpose of this study is to identify problems occurred by the increasing number of elderly people living alone to obtain a solution for the problems and suggest a service design to attract young people in their 20s, who is more likely to favor voluntary service and donation for solution. For a study method, an observational study was conducted with selecting people who are engaged in senior care center, students in their 20s, and elderly people living alone and conducting questionnaire and in-depth interview with them and the problems occurred among those interested parties. The application steps were being simplified by dividing them into major categories, `performing voluntary service` and `donating`, to solve the problems. Also, `berry` points obtained by a voluntary service, which is an essentially time-donating, is available for designated financial donation. Those functions were manufactured as a mobile application prototype and first and second usability tests were conducted. As a result, it is expected that this study will contribute to creation of new donation culture with students in their 20s and solution for elderly people living alone.
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