http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Marco Lamberti,Gabriella Di Rosa,Francesca Cucinotta,Erica Pironti,Cecilia Galati,Antonella Gagliano 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
In the last years second-generation antipsychotics are increasingly prescribed in the pediatric population for the treatment of several psychiatric disorders. Among the long term adverse effects, extrapyramidal symptoms (EPS) are less reported compared to first-generation antipsychotics. Tardive dyskinesia (TD) is a iatrogenic rare syndrome characterized by persistent slow writhing and sudden involuntary movements mainly involving the oral-buccal-lingual area with masticatory movements. We report a young girl with mood disorders accompanied by mild intellectual disability and behavioral problems who had TD after treatment with Aripiprazole, which responded to Biperiden therapy.
Van Oss, S. Branden,Shirra, Margaret K.,Bataille, Alain R.,Wier, Adam D.,Yen, Kuangyu,Vinayachandran, Vinesh,Byeon, In-Ja L.,Cucinotta, Christine E.,Hé,roux, Annie,Jeon, Jongcheol,Kim, Jaehoon,V Elsevier 2016 Molecular cell Vol.64 No.4
<P><B>Summary</B></P> <P>The five-subunit yeast Paf1 complex (Paf1C) regulates all stages of transcription and is critical for the monoubiquitylation of histone H2B (H2Bub), a modification that broadly influences chromatin structure and eukaryotic transcription. Here, we show that the histone modification domain (HMD) of Paf1C subunit Rtf1 directly interacts with the ubiquitin conjugase Rad6 and stimulates H2Bub independently of transcription. We present the crystal structure of the Rtf1 HMD and use site-specific, in vivo crosslinking to identify a conserved Rad6 interaction surface. Utilizing ChIP-exo analysis, we define the localization patterns of the H2Bub machinery at high resolution and demonstrate the importance of Paf1C in targeting the Rtf1 HMD, and thereby H2Bub, to its appropriate genomic locations. Finally, we observe HMD-dependent stimulation of H2Bub in a transcription-free, reconstituted in vitro system. Taken together, our results argue for an active role for Paf1C in promoting H2Bub and ensuring its proper localization in vivo.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Histone modification domain (HMD) of Rtf1 directly contacts Rad6 in vivo </LI> <LI> HMD structure and in vivo crosslinking identify a conserved Rad6 interaction surface </LI> <LI> Paf1C regulates global H2B ubiquitylation (ub) patterns by linking HMD to Pol II </LI> <LI> HMD stimulates Bre1-dependent H2Bub in a transcription-free, reconstituted assay </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>