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Study on the Internet Financial Risks in China
Li. Chuanyang,Hyun-rae ,Cho 大田大學校 社會科學硏究所 2020 社會科學論文集 Vol.- No.-
The Internet finance is a new model of finance. It has many characteristics, such as high-efficiency, immediacy and universality. Although it appeared not early in China, the Internet finance develops promptly both in the scale and speed. Due to the lack of correspondent legal systems and mature technologies, there are legal risks, perational risks, business management risks and technical risks. Making perfect Internet financial laws and regulations, introducing the supporting policies for the development of the Internet financial industry, and strengthening the industry self-discipline are the key to reducing the Internet financial risk.
Compilation of load spectrum of machining center spindle and application in fatigue life prediction
Guofa Li,Shengxu Wang,Jialong He,Kai Wu,Chuanyang Zhou 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.4
The load spectrum of machining center (MC) is the data basis for fatigue life prediction. A novel compiling method of dynamic cutting load spectrum of MC spindle is proposed, and then applied to the fatigue life prediction. Typical process parameters were determined based on the data collected in the user field by establishing the characteristic load distribution, and dynamic cutting load was measured using the load test platform. Mean-frequency and amplitude-frequency matrices of the load were obtained by the rainflow counting method, and mixture Weibull distribution (MWD) was used to establish the mean and amplitude distribution. Thus, the two-dimensional dynamic cutting load spectrum of spindle was compiled. The eight-level program load spectrum was established, and then applied to the spindle fatigue life prediction. The accuracy of load spectrum is improved because of the MWD, instead of single distribution, and the complete load spectrum compilation process also improves the life prediction accuracy.
Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Zhao Qiuyan,Zhu Zhonglin,Xiao Wenqin,Zong Guanzhao,Wang Chuanyang,Jiang Weiliang,Li Kai,Shen Jie,Guo Xingya,Cui Jianhua,Guo Lihong,Wan Rong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.