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Development of New Edible Pigments using Monascus spp.
Cho, Gyu-Seong,Kim, Kwangwook,Park, Won-Jong The Korean Society of Food and Nutrition 2019 韓國食品營養學會誌 Vol.32 No.1
Carotene, xanthophyll, carotenoid anthocyan, phycopyrine, chlorophyll, and monascus pigments are used as natural coloring agents since they are more stable to human body than synthetic coloring agents. Among them, monascus pigments are a natural red pigment produced by the Monascus purpureus. For the development of edible paint using natural pigment, Monascus purpureus strain was cultured at a temperature of $35^{\circ}C$ for 15 days on a PDYA plate and liquid medium to produce a red pigment. In addition, a large amount of the red pigment was extracted from Hongkuk Koji in parallel with water extraction and ultrasonic wave extraction. At this time, the yield of ultrasonic extract was 2~4 times higher. Thus, Monascus purpureus strains, etc. were prepared by freeze-drying powder. In conclusion, natural paints made with red pigments have enabled the development of been edible paints that can be used as eco-friendly materials with good viscosity, enhanced spread ability and coloration.
유방암 환자에서 항암 치료 중 생긴 체중 변화와 재발과의 상관 관계
서광욱(Kwangwook Seo),조현진(Hyunjin Cho),안훈(Hoon An),박인석(Insuk Park),곽금희(Geumhee Gwak),양근호(Keunho Yang),배병노(Byungnoe Bae),김기환(Kihwan Kim) 대한종양외과학회 2013 Korean Journal of Clinical Oncology Vol.9 No.2
Purpose: Weight change during chemotherapy is reported to be associated with a worse prognosis in breast cancer. Our study was aimed to evaluate the relation of weight change during AC (anthracycline+cyclophosphamide) +taxanes chemotherapy and recurrence. Methods: Patients included 89 women diagnosed with breast cancer who have been treated by AC+taxenes chemotherapy regimen. The weight variation between prechemotherapy and postchemotherapy was calculated ([weight at postchemotherapy-weight at prechemotherapy]/weight at prechemotherapy×100) and categorized into either weight change (≥5%) or stable (<5%). And then, we evaluated the relation of weight change and recurrence through the radiologic image tests (positron emission tomography-computed tomography, breast sonography, mammography, bone scan, magnetic resonance imaging, abdomino-pelvic computed tomography) each group. Results: During chemotherapy, 37of total 89 patients (41.6%) presented notable weight change and 52 patients (58.4%) were not weight change. Median follow-up period was 45.1 months, 17 of total 89 patients (19.1%) presented recurrence on the radiologic image tests. Eight of 17 recurrence patients were presented notable weight change, 9 patients were not weight change. In univariate analyses, weight change was not associated with recurrence. Conclusion: In our study, weight change during AC+taxanes chemotherapy in breast cancer was not associated with recurrence. Many studies that relation of weight change and recurrence were presented various result. So, we need more clinical studies many patients included and well designed.
새싹보리 잎, 뿌리 및 줄기 에탄올 추출물의 항산화 활성 및 신경세포 보호 효과 비교
변의홍(Eui-Hong Byun),김광욱(Kwangwook Kim),김이은(Yi-Eun Kim),조은지(Eun-Ji Cho),민희숙(Hee-Suk Min),이정현(Jeong-Hyeon Lee),조규성(Gyu-Seong Cho),윤우정(Woo Jung Yoon),김병천(Byung Chean Kim),안동현(Dong-Hyun Ahn),박원종(Won-Jong P 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.10
새싹보리는 보리(Hordeum vulgare L.) 종자에서 발생한 싹을 키워 발아한 지 일주일 정도 된 어린 보리이며 완전히 자란 보리보다 기능성 물질을 다량 함유하고 있다고 알려져 있다. 이런 새싹보리의 부위별 생리활성 연구는 많이 미흡한 실정이다. 따라서 본 연구에서는 새싹보리의 잎, 뿌리, 줄기에탄올 추출물의 총 폴리페놀과 플라보노이드 함량, 항산화활성 및 신경세포 보호 효과에 관하여 비교하였다. 천연물 항산화력의 지표물질인 폴리페놀 및 플라보노이드 함량은 새싹보리의 뿌리, 줄기보다 잎에서 더욱 높게 측정되었으며, 새싹보리 잎이 DPPH, ABTS 라디칼 소거능 및 환원력 평가에서도 뿌리, 줄기보다 더 높은 항산화 활성을 관찰되었다. 또한, 새싹보리 잎, 뿌리 및 줄기의 신경세포 보호 효과를 확인하기 위해 H₂O₂로 산화적 스트레스를 유도하여 세포 독성, SOD 활성 및 MDA level을 확인한 결과, 새싹보리 잎에서 세포 생존율 증가, SOD 활성 증가 및 MDA level감소가 가장 높게 관찰되었다. 이는 새싹보리의 잎이 다른 부위인 뿌리, 줄기보다 천연 항산화 소재와 신경세포 보호소재로 개발될 가능성이 월등히 높다는 것을 보여주고 있다. It is believed that barley sprouts (Hordeum vulgare L.) have antioxidant, lipid metabolic, anti-cancer, and anti-fatty liver formation effects; however, no studies have been conducted to confirm this. Therefore, the present study was conducted to compare the leaf, root, and stem extracts of barley sprouts in terms of their total polyphenol contents, flavonoid contents, antioxidant activities, and neuroprotective effects. To accomplish this, barley sprout leaves, roots, and stems were individually extracted using ethanol. The highest levels of total polyphenols and total flavonoids were observed in barley sprout leaf extract. Similarly, antioxidant activities resulted in radical scavenging activities [2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] and reduced power increased significantly in the extract of barley sprout leaves. In addition, barley sprout leaves, roots, and stems significantly increased cell viability in H₂O₂-treated HT22 cells. Further, barley sprout leaves increased superoxide dismutase activity and decreased the malonaldehyde level. In conclusion, these results indicate that leaves of barley sprouts can be used as a new natural antioxidant source and that they have the potential to prevent and treat neuro-degenerative diseases.
Yang Jinyoung,Hyeon Seokhwan,Baek Jin Yang,Kang Min Seo,Lee Keon Young,Lee Young Ho,Huh Kyungmin,Cho Sun Young,Kang Cheol-In,Chung Doo Ryeon,Peck Kyong Ran,Won Gunho,Lee Hye Won,Kim Kwangwook,Hwang In 대한의학회 2023 Journal of Korean medical science Vol.38 No.27
Tixagevimab/cilgavimab is a monoclonal antibody used to prevent coronavirus disease 2019 among immunocompromised hosts and maintained neutralizing activity against early omicron variants. Omicron BN.1 became a dominant circulating strain in Korea early 2023, but its susceptibility to tixagevimab/cilgavimab is unclear. We conducted plaque reduction neutralization test (PRNT) against BN.1 in a prospective cohort (14 patients and 30 specimens). BN.1 PRNT was conducted for one- and three-months after tixagevimab/ cilgavimab administration and the average PRNT ND50 of each point was lower than the positive cut-off value of 20 (12.9 ± 4.5 and 13.2 ± 4.2, respectively, P = 0.825). In the paired analyses, tixagevimab/cilgavimab-administered sera could not actively neutralize BN.1 (PRNT ND50 11.5 ± 2.9, P = 0.001), compared with the reserved activity against BA.5 (ND50 310.5 ± 180.4). Unlike virus-like particle assay, tixagevimab/cilgavimab was not active against BN.1 in neutralizing assay, and would not be effective in the present predominance of BA.2.75 sublineages.
Mahmood, Usman,Ahn, Sangzin,Yang, Eun-Jeong,Choi, Moonseok,Kim, Hyunju,Regan, Philip,Cho, Kwangwook,Kim, Hye-Sun Elsevier 2018 PHARMACOLOGICAL RESEARCH Vol.128 No.-
<P><B>Abstract</B></P> <P>Mounting evidence suggests that the etiology of autism spectrum disorders (ASDs) is profoundly influenced by exposure to environmental factors, although the precise molecular and cellular links remain ill-defined. In this study, we examined how exposure to valproic acid (VPA) during pregnancy is associated with an increased incidence of ASD. A mouse model was established by injecting VPA at embryonic day 13, and its behavioral phenotypes including impaired social interaction, increased repetitive behaviors and decreased nociception were observed at postnatal days 21–42. VPA-treated mice showed dysregulation of synaptic structure in cortical neurons, including a reduced proportion of filopodium-type and stubby spines and increased proportions of thin and mushroom-type spines, along with a decreased spine head size. We also found that VPA-treatment led to decreased expression of phosphate and tensin homolog (PTEN) and increased levels of <I>p</I>-AKT protein in the hippocampus and cortex. Our data suggest that there is a correlation between VPA exposure and dysregulation of PTEN with ASD-like behavioral and neuroanatomical changes, and this may be a potential mechanism of VPA-induced ASD.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>