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Anti-inflammatory Mechanism of Seaweeds in Murine Macrophage
Cheol-Ho Pan,Eun Sun Kim,Byung Hun Um,Jae Kwon Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3
The effect of 4 seaweed extracts (Desmarestia viridis, Dictyopteris divaricata, Scytosiphon lomentaria, and Ishige okamurae) on pro-inflammatory mediators as well as nuclear factor (NF)-κB in the stimulated Raw 264.7 cells was investigated. They reduced iNOS and interlukin (IL)-1β expressions at transcription level. Of those, 3 extracts (D. divaricata, I. okamurae, and S. lomentaria) inhibited the COX-2 expression at translation level. IκB-α degradation was inhibited by D. divaricata and S. lomentaria extracts. Therefore, we concluded that the extracts from D. divaricata and S. lomentaria could inhibit the activation of murine macrophage through the blocking of NF-κB activation.
Pan, Cheol-Ho,Kim, Eun-Sun,Jung, Sang-Hoon,Nho, Chu-Won,Lee, Jae-Kwon 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Tectorigenin (Tg) and tectoridin (Td) are the major compounds isolated from the rhizomes of iridaceous plant Belamcanda chinensis which is well known as a chinese traditional medicine for the treatment of inflammatory diseases. In this study we investigated whether tectorigenin and tectoridin can be applied to the suppression of interferon-$\gamma$ and lipopolysaccharide (IFN-$\gamma$/LPS)-induced inflammatory responses in macrophages. Anti-inflammatory activities of tectorigenin and tectoridin were compared with genistein (Ge), well known isoflavonoid as a phytoestrogen and regarded as an emerging anti-inflammatory agent. Both compounds showed low cytotoxic effect. In Raw 264.7 cells activated with $IFN-{\gamma}$/LPS, pre-treated tectorigenin was found to inhibit the expression of inducible nitric oxide synthase (iNOS), the production of nitric oxide (NO) and the secretion of interleukin (IL)-$1{\beta}$ dose-dependently. Tectorigenin also decreased the expression of cyclooxigenase (COX)-2 and the production of prostaglandin $E_2$ ($PGE_2$) in dose-dependent manner. These inhibitory effects of tectorigenin were found to be caused by the blocking of nuclear factor kappa-B (NF-${\kappa}B$) activation. Compared with genistein and tectoridin, tectorigenin showed significant inhibitory effect for almost anti-inflammatory tests in this study. All these results clearly demonstrated that tectorigenin appears to have the potential to prevent inflammation.
심전도의 이상치 신호 제거를 이용한 Xception 기반 스트레스 분류
송철호(Cheol Ho Song),김진수(Jin Su Kim),최규호(Gyu Ho Choi),반성범(Sungbum Pan) 한국정보기술학회 2023 한국정보기술학회논문지 Vol.21 No.5
ECG-based stress classification studies are being conducted to prevent the occurrence of diseases caused by stress. The method through digital filtering used in previous studies has a problem in that it cannot remove noise that damages the periodic characteristics of the ECG, such as motion artifacts. Therefore, in this paper, we propose an Xception-based stress classification system using ECG outlier signal removal. The proposed system uses the Xception classifier after removing the outlier signal through similarity comparison based on the R-R interval of the ECG. The stress classification experiment showed a maximum performance of 98.6%, which is 0.92% higher than before removing the outlier signal, and showed more than 5.6% improved performance in two class classification compared to stress classification studies using ECG.