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전학철(Xuezhe Quan),허신유(Chenyu Xu),구자숙(Jasook Koo) 한국경영사학회 2022 經營史學 Vol.104 No.-
본 연구는 선행 연구에 대한 의논 결과를 기초하여 도전 관련 스트레스와 방해 관련 스트레스로 분류된 스트레스가 개인에게 미치는 긍정적 및 부정적 영향을 살펴보며, 그와 함께 직무성과 및 직무만족 간의 내적 메커니즘에 대해 연구하였다. 구체적으로 먼저 도전 관련 스트레스와 방해 관련 스트레스가 직무성과와 직무만족에 미치는 영향을 살펴본 후 도전평가와 통제평가의 매개효과에 대해 살펴보았으며 마지막으로 인지된 조직 지원의 조절효과에 대해 살펴보았다. 본 연구에서는 중국의 318명 회사원을 대상으로 온라인 설문조사를 실시하였다. 분석결과 도전 관련 스트레스가 높을수록 도전평가를 많이 함으로써 직무성과 및 직무만족이 증진되었으며, 방해 관련 스트레스가 높을수록 통제평가를 많이 함으로써 직무성과 및 직무만족이 약화되었다. 이 과정에서 인지된 조직 지원이 높을 경우에는 도전 관련 스트레스가 도전 평가에 미치는 영향이 더 강하게 나타났으며 방해 관련 스트레스가 통제평가에 미치는 영향에는 조절효과 없는 것으로 나타났다. 마지막으로 본 연구의 결과를 통해 연구의 시사점, 한계점 등을 논의하였다. Based on the discussion results of previous studies, this study examines the positive and negative effects of stress classified as challenge-related stress and interruption-related stress on individuals, and studies the internal mechanism between job performance and job satisfaction. Specifically, first, the effects of challenge-related stress and interruption-related stress on job performance and job satisfaction were examined, then the mediating effects of challenge appraisal and control appraisal were examined, and finally, the moderating effect of perceived organizational support was examined. In this study, an online survey was conducted targeting 318 office workers in China. As a result of the analysis, the higher the stress related to challenge, the more challenge appraisals were performed, thereby improving job performance and job satisfaction. In this process, when perceived organizational support was high, the effect of challenge-related stress on challenge appraisal was higher, and there was no moderating effect on the effect of hinderance-related stress on control appraisal. Finally, the implications and limitations of the study were discussed through the results of this study.
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Liu Xiaoyi,Wei Qinglv,Yang Chenyue,Zhao Hongyan,Xu Jie,Mobet Youchaou,Luo Qingya,Yang Dan,Zuo Xinzhao,Chen Ningxuan,Yang Yu,Li Li,Wang Wei,Yu Jianhua,Xu Jing,Liu Tao,Yi Ping 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
5-Methylcytosine (m5C) is a common RNA modification that modulates gene expression at the posttranscriptional level, but the crosstalk between m5C RNA modification and biomolecule condensation, as well as transcription factor-mediated transcriptional regulation, in ovarian cancer, is poorly understood. In this study, we revealed that the RNA methyltransferase NSUN2 facilitates mRNA m5C modification and forms a positive feedback regulatory loop with the transcription factor E2F1 in ovarian cancer. Specifically, NSUN2 promotes m5C modification of E2F1 mRNA and increases its stability, and E2F1 binds to the NSUN2 promoter, subsequently reciprocally activating NSUN2 transcription. The RNA binding protein YBX1 functions as the m5C reader and is involved in NSUN2-mediated E2F1 regulation. m5C modification promotes YBX1 phase separation, which upregulates E2F1 expression. In ovarian cancer, NSUN2 and YBX1 are amplified and upregulated, and higher expression of NSUN2 and YBX1 predicts a worse prognosis for ovarian cancer patients. Moreover, E2F1 transcriptionally regulates the expression of the oncogenes MYBL2 and RAD54L, driving ovarian cancer progression. Thus, our study delineates a NSUN2-E2F1-NSUN2 loop regulated by m5C modification in a manner dependent on YBX1 phase separation, and this previously unidentified pathway could be a promising target for ovarian cancer treatment.
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Lianzhou Yang,Yuchen Cai,Dongsheng Zhang,Jian Sun,Chenyu Xu,Wenli Zhao,Wenqi Jiang,Chunhua Pan 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: Immune suppression is common in patients with advanced breast cancer but the mechanisms underlying this phenomenon have not been sufficiently studied. In this study, we aimed to identify B7 family members that were able to predict the immune status of patients, and which may serve as potential targets for the treatment of breast cancer. We also aimed to identify microRNAs that may regulate the expression of B7 family members. Methods: The Cancer Genome Atlas data from 1,092 patients with breast cancer, including gene expression, microRNA expression and survival data, were used for statistical and survival analyses. Polymerase chain reaction and Western blot were used to measure messenger RNA and protein expression, respectively. Luciferase assay was used to investigate direct microRNA target. Results: Bioinformatic analysis predicted that microRNA (miR)-93, miR-195, miR-497, and miR-340 are potential regulators of the immune evasion of breast cancer cells, and that they exert this function by targeting CD274, PDCD1LG2, and NCR3LG1. We chose CD274 for further investigations. We found that miR-195, miR-497, and CD274 expression levels were inversely correlated in MDA-MB-231 cells, and miR-195 and miR-497 expressions mimic inhibited CD274 expression in vitro. Mechanistic investigations demonstrated that miR-195 and miR-497 directly target CD274 3´ untranslated region. Conclusion: Our data indicated that the level of B7 family members can predict the prognosis of breast cancer patients, and miR-195/miR-497 regulate CD274 expression in triple negative breast cancer. This regulation may further influence tumor progression and the immune tolerance mechanism in breast cancer and may be able to predict the effect of immunotherapy on patients.
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KCI
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