The Multiformity of Asian Music: A Comparative Study on Current situation Between Indian, Chinese and Philippine Music

Chen,Ziming 아시아음악학회 2003 Asian Musicology Vol.3 No.-

Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy

Chen Ziming,Li Mengyuan,Chen Peilin,Tai Andrew,Li Jiayue,Bassonga Euphemie Landao,Gao Junjie,Liu Delin,Wood David,Kennedy Brendan F.,Zheng Qiujian,Zheng Ming H. 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

Tendinopathy is one of the most common musculoskeletal diseases, and mechanical overload is considered its primary cause. However, the underlying mechanism through which mechanical overload induces tendinopathy has not been determined. In this study, we identified for the first time that tendon cells can release extracellular mitochondria (ExtraMito) particles, a subtype of medium extracellular particles (mEPs), into the environment through a process regulated by mechanical loading. RNA sequencing systematically revealed that oxygen-related reactions, extracellular particles, and inflammation were present in diseased human tendons, suggesting that these factors play a role in the pathogenesis of tendinopathy. We simulated the disease condition by imposing a 9% strain overload on three-dimensional mouse tendon constructs in our cyclic uniaxial stretching bioreactor. The three-dimensional mouse tendon constructs under normal loading with 6% strain exhibited an extended mitochondrial network, as observed through live-cell confocal laser scanning microscopy. In contrast, mechanical overload led to a fragmented mitochondrial network. Our microscopic and immunoblot results demonstrated that mechanical loading induced tendon cells to release ExtraMito particles. Furthermore, we showed that mEPs released from tendon cells overloaded with a 9% strain (mEP9%) induced macrophage chemotaxis and increased the production of proinflammatory cytokines, including IL-6, CXCL1, and IL-18, from macrophages compared to mEP0%, mEP3%, and mEP6%. Partial depletion of the ExtraMito particles from mEP9% by magnetic-activated cell sorting significantly reduced macrophage chemotaxis. N-acetyl-L-cysteine treatment preserved the mitochondrial network in overloaded tendon cells, diminishing overload-induced macrophage chemotaxis toward mEP9%. These findings revealed a novel mechanism of tendinopathy; in an overloaded environment, ExtraMito particles convey mechanical response signals from tendon cells to the immune microenvironment, culminating in tendinopathy.

Uncovering the Face of Android Ransomware: Characterization and Real-Time Detection

Chen, Jing,Wang, Chiheng,Zhao, Ziming,Chen, Kai,Du, Ruiying,Ahn, Gail-Joon IEEE 2018 IEEE transactions on information forensics and sec Vol.13 No.5

<P>In recent years, we witnessed a drastic increase of ransomware, especially on popular mobile platforms including Android. Ransomware extorts victims for a sum of money by taking control of their devices or files. In light of their rapid growth, there is a pressing need to develop effective countermeasure solutions. However, the research community is still constrained by the lack of a comprehensive data set, and there exists no insightful understanding of mobile ransomware in the wild. In this paper, we focus on the Android platform and aim to characterize existing Android ransomware. Specifically, we have managed to collect 2,721 ransomware samples that cover the majority of existing Android ransomware families. Based on these samples, we systematically characterize them from several aspects, including timeline and malicious features. In addition, the detection results of existing anti-virus tools are rather disappointing, which clearly calls for customized anti-mobile-ransomware solutions. To detect ransomware that extorts users by encrypting data, we propose a novel real-time detection system, called RansomProber. By analyzing the user interface widgets of related activities and the coordinates of users’ finger movements, RansomProber can infer whether the file encryption operations are initiated by users. The experimental results show that RansomProber can effectively detect encrypting ransomware with high accuracy and acceptable runtime performance.</P>

SiC IGBT degradation mechanism investigation under HV‑H3TRB tests

Ziming Wu,Zongbei Dai,Jian Zhou,Huafeng Dong,Wencan Wang,Feiwan Xie,Haoran Wang,Jiahui Yan,Xiyu Chen,Shaohua Yang,Fugen Wu 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.2

The high voltage-high humidity-high temperature reverse bias (HV-H3TRB) test was utilized to evaluate the reliability of silicon carbide insulated gate bipolar transistors (SiC IGBTs). Moisture invasion often induces termination/passivation and metal corrosion. Therefore, the HV-H3TRB test is generally used to assess termination / passivation robustness. However, under the HV-H3TRB test conditions, gate quality degradation may occur. In this study, the dominant degradation mechanism of SiC IGBTs was investigated. The changes of the most sensitive static characteristics (e.g., threshold voltage, breakdown voltage, and leakage current) were recorded. The threshold voltage decreased and leakage current increased substantially after > 1000 h of HV-H3TRB tests under 85 ℃/85% RH climate conditions. Capacitance-voltage (C-V) curve measurements indicated that the mobile ions at the SiC/SiO2 interface or in the gate oxide likely caused the threshold-voltage instability in the SiC IGBTs after the HV-H3TRB tests. This instability can be recovered by applying a negative gate bias. Subsequent failure analysis confirmed no corrosion of metals or termination/passivation in the device, which indicates the robustness of the passivation (consisting of phosphor-silicate glass and Si3N4). Therefore, the gate quality appears to be a significant reliability risk for SiC IGBTs under high humidity, high temperature, and high voltage conditions.

Rapid construction delivery of COVID-19 special hospital: Case study on Wuhan Huoshenshan hospital

Wang, Chen,Yu, Liangcheng,Kassem, Mukhtar A.,Li, Heng,Wang, Ziming Techno-Press 2022 Advances in computational design Vol.7 No.4

Infectious disease emergency hospitals are usually temporarily built during the pneumonia epidemic with higher requirements regarding diagnosis and treatment efficiency, hygiene and safety, and infection control.This study aims to identify how the Building Information Modeling (BIM) + Industrialized Building System (IBS) approach could rapidly deliver an infectious disease hospital and develop site epidemic spreading algorithms. Coronavirus-19 pneumonia construction site spreading algorithm model mind map and block diagram of the construction site epidemic spreading algorithm model were developed. BIM+IBS approach could maximize the repetition of reinforced components and reduce the number of particular components. Huoshenshan Hospital adopted IBS and BIM in the construction, which reduced the workload of on-site operations and avoided later rectification. BIM+IBS integrated information on building materials, building planning, building participants, and construction machinery, and realized construction visualization control and parametric design. The delivery of Huoshenshan Hospital was during the most critical period of the Coronavirus-19 pneumonia epidemic. The development of a construction site epidemic spreading algorithm provided theoretical and numerical support for prevention. The agent-based analysis on hospital evacuation observed "arched" congestion formed at the evacuation exit, indicating behavioral blindness caused by fear in emergencies.

Licochalcone A, a Natural Inhibitor of c-Jun <i>N</i>-Terminal Kinase 1

Yao, Ke,Chen, Hanyong,Lee, Mee-Hyun,Li, Haitao,Ma, Weiya,Peng, Cong,Song, Nu Ry,Lee, Ki Won,Bode, Ann M.,Dong, Ziming,Dong, Zigang American Association for Cancer Research 2014 Cancer Prevention Research Vol.7 No.1

<P>The c-<I>Jun N</I>-terminal kinases (JNK) play an important role in many physiologic processes induced by numerous stress signals. Each JNK protein appears to have a distinct function in cancer, diabetes, or Parkinson's disease. Herein, we found that licochalcone A, a major phenolic constituent isolated from licorice root, suppressed JNK1 activity but had little effect on JNK2 <I>in vitro</I> activity. Although licochalcone A binds with JIP1 competitively with either JNK1 or JNK2, a computer simulation model showed that after licochalcone A binding, the ATP-binding cleft of JNK1 was distorted more substantially than that of JNK2. This could reduce the affinity of JNK1 more than JNK2 for ATP binding. Furthermore, licochalcone A inhibited JNK1-mediated, but not JNK2-mediated, c-Jun phosphorylation in both <I>ex vivo</I> and <I>in vitro</I> systems. We also observed that in colon and pancreatic cancer cell lines, JNK1 is highly expressed compared with normal cell lines. In cancer cell lines, treatment with licochalcone A or knocking down JNK1 expression suppressed colon and pancreatic cancer cell proliferation and colony formation. The inhibition resulted in G<SUB>1</SUB> phase arrest and apoptosis. Moreover, an <I>in vivo</I> xenograft mouse study showed that licochalcone A treatment effectively suppressed the growth of HCT116 xenografts, without affecting the body weight of mice. These results show that licochalcone A is a selective JNK1 inhibitor. Therefore, we suggest that because of the critical role of JNK1 in colon cancer and pancreatic carcinogenesis, licochalcone A might have preventive or therapeutic potential against these devastating diseases. <I>Cancer Prev Res; 7(1); 139–49. ©2013 AACR</I>.</P>

Information Extraction of Rock Mass structure in Complex Bedrock Mountain Area Based on UAV Oblique Photogrammetry

( Fengyan Wang ),( Mingyu Zhao ),( Fujun Zhou ),( Kai Zhou ),( Qing Ding ),( Ziming Wang ),( Jianping Chen ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

As a new technology developed in recent years, the UAV oblique photogrammetry is of long-distance, non-contact, high-precision and high-density to acquire rapidly 3D spatial data of the object, which has been applied in geological surveying and mapping. Taking the discontinuity information acquisition from Changdu to Linzhi section of Sichuan-Tibet railway in China as an example, 3D model of the survey area is reconstructed by UAV oblique photogrammetry, and the discontinuities are identified and measured in the model by using the 3D mapping system-EPS. Combined with the solution models of discontinuity parameters, the trace length, orientation and opening degree are calculated. Furthermore, the probability distribution of trace length, the dominant grouping of orientation are obtained by probability theory and mathematical statistics. Also, the model display diagram of 3D trace line for long discontinuities, the pole point diagram of orientation, the rose diagram of joint direction and other related maps are drawn by computer graphics so as to describe and cognize the spatial characteristic of complex rock mass structure, which can provide the basic data for stability evaluation of lithological slope and following railway design. The research shows that UAV oblique photogrammetry technology can be applied in discontinuity information extraction of the complex bedrock mountain area compared with the traditional manual measurement, reduces physical input and personal risk, and improve the precision and efficiency of survey, which has a broad application prospects.

RBPJ contributes to acquired docetaxel resistance in prostate cancer cells

Li Xue,Zhenlong Wang,Hecheng Li,Zhaolun Li,Qi Chen,Peng Zhang,Haiwen Chen,Ziming Wang,Tie Chong,T. Chong 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3

Our previous work has shown that depletion of recombination signal-binding protein J (RBPJ) results in reduced cell growth in prostate cancer cells. In this study, we aimed to investigate the function of RBPJ in the chemoresistance of prostate cancer. The expression of RBPJ was quantified in docetaxel-resistant and parental prostate cancer cells. Loss- and gainof- function experiments were conducted to explore the regulatory role of RBPJ in prostate cancer sensitivity to docetaxel. The pro-apoptotic effect of RBPJ silencing was checked in docetaxel-resistant prostate cancer cells. We found that docetaxel-resistant PC3-DR and DU145- DR cells expressed 3-5-fold high levels of RBPJ than parental PC3 and DU145 cells. Short hairpin RNAmediated knockdown of RBPJ inhibited cell proliferation and colony formation and reversed docetaxel resistance in docetaxel-resistant prostate cancer cells. In contrast, overexpression of RBPJ promoted cell growth, colony formation, and docetaxel resistance in parental prostate cancer cells. Downregulation of RBPJ induced apoptosis in docetaxel-resistant cells, which was accompanied by enhanced cleavage of caspase-3. In addition, RBPJ silencing or overexpression markedly modulated the expression of the Bcl-2 family members including Bcl-2, Bcl-xL, Mcl-1, Bax, and Bak. Altogether, RBPJ contributes to acquisition of docetaxel resistance in prostate cancer cells and may thus represent a potential target for overcoming chemotherapeutic resistance in this malignancy.