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전봉근(BongKeun Jeon),송창섭(ChangSeop Song),금영탁(YoungTag Keum) Korean Society for Precision Engineering 2009 한국정밀공학회지 Vol.26 No.5
An electric furnace, inside which desired temperatures are kept constant by generating heat, is known to be a difficult system to control and model exactly because system parameters and response delay time vary as the temperature and position are changed. In this study, the heating system of ceramic drying furnaces with time-varying parameters is mathematically modeled as a second order system and control parameters are estimated by using a RIV (Recursive Instrumental-Variable) method. A modified bang-bang control with magnitude tuning is proposed in the time optimal temperature control of ceramic drying electric furnaces and its performance is experimentally verified. It is proven that temperature tracking of adaptive time optimal control using a second order model is more stable than the GPCEW (Generalized Predictive Control with Exponential Weight) and rapidly settles down by pre-estimation of the system parameters.
박윤정,차재호,Bongkeun Song,Yan Huang,Seoyoung Kim,김수현,Eunhye Jo,Samantha Fortin,안순모 한국해양과학기술원 2020 Ocean science journal Vol.55 No.1
We examined the effects of changing from oxic to anoxic conditions on microbial communities using both biogeochemical and molecular approaches in a semi-enclosed estuary (Jinhae Bay, Republic of Korea). Total microbial activity, represented by oxygen demand in the water column (WOD) or sediment (SOD), revealed that the respective microbial communities in the water and sediment responded differently to low dissolved-oxygen (DO) conditions. In the sediment, SOD and the total microbial abundance, as assessed by quantitative polymerase chain reaction (qPCR) analysis, decreased under low DO conditions, indicating that the microbial adaptation to anaerobic metabolism was not well established during hypoxia development. In the water column, however, neither the total abundance of microbes nor the WOD were affected by hypoxic conditions. Regardless of DO concentration, WOD showed a positive correlation with water temperature, implying that the aerobic metabolism was sustained even under hypoxic conditions, through the intermittent supply of oxygen. In addition to the spatially different responses of microorganisms, unique responses of specific groups were noted in sulfur (S) cycling microbes. Sulfide-oxidizing prokaryotes (SOP) dominated in the water column, and no significant changes were evident in their abundance or diversity with hypoxia. However, in sediment, distinctive sulfate-reducing bacteria (SRB) were present at each sampling period during hypoxia development (a “SRB succession”), implying that each SRB group has varying sensitivity to DO and other electron acceptors. Vertical profiles of dissolved inorganic nitrogen, including ammonium (NH4 +) and nitrate (NO3 −), and changes in archaeal abundance suggest that NH4 +-oxidizing archaea (AOA) might vary spatially and temporally, depending on NH4 + and oxygen availability in the water column, under mature hypoxic conditions, which is similar to the nitrogen (N) dynamics in the permanent oxygen minimum zone (OMZ).
Study on the Single Dose Toxicity of ShinEumHur Pharmacopuncture Injected into the Muscles of Rats
Jeong, Hohyun,Cha, Eunhye,Lee, Jongcheol,Lee, Seongjin,Park, Manyong,Kim, Dongwoung,Song, Bongkeun,Lee, Jongdeok,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2016 Journal of pharmacopuncture Vol.19 No.4
Objectives: This study was carried out to analyze the single dose toxicity of ShinEumHur (SEH) pharmacopuncture injected into the muscles of Sprague-Dawley rats. Methods: The SEH pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (K-GMP). After the mixing process with sterile distilled water had been completed, the pH was controlled to between 7.0 and 7.5. All experiments were conducted at Biotoxtech, an institution authorized to perform non-clinical studies under the Good Laboratory Practice (GLP) regulations. Sprague-Dawley rats were chosen for the pilot study. Doses of SEH pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. We examined the survival rate, weights, clinical signs, mean hematology parameters, mean clinical chemistry, necropsy and histopathological findings. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results: No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The above findings suggest that treatment with SEH pharmacopuncture is relatively safe. Further studies on this subject are needed to yield more concrete evidence.
Sul, Woo-Jun,Kim, In-Soo,Ekpeghere, Kalu I.,Song, Bongkeun,Kim, Bong-Soo,Kim, Hong-Gi,Kim, Jong-Tae,Koh, Sung-Cheol Taylor & Francis Inc. 2016 Journal of Environmental Science and Health. Part Vol.51 No.13
<P>Nitrogen (N) removal in a tannery wastewater treatment plant was significantly enhanced by the bioaugmentation of the novel consortium BM-S-1. In order to identify dominant taxa responsible for N metabolisms in the different stages of the treatment process, Illumina MiSeq Sequencer was used to conduct metagenome sequencing of the microbial communities in the different stages of treatment system, including influent (I), buffering (B), primary aeration (PA), secondary aeration (SA) and sludge digestion (SD). Based on MG-RAST analysis, the dominant phyla were Proteobacteria, Bacteroidetes and Firmicutes in B, PA, SA and SD, whereas Firmicutes was the most dominant in I before augmentation. The augmentation increased the abundance of the denitrification genes found in the genera such as Ralstonia (nirS, norB and nosZ), Pseudomonas (narG, nirS and norB) and Escherichia (narG) in B and PA. In addition, Bacteroides, Geobacter, Porphyromonasand Wolinella carrying nrfA gene encoding dissimilatory nitrate reduction to ammonium were abundantly present in B and PA. This was corroborated with the higher total N removal in these two stages. Thus, metagenomic analysis was able to identify the dominant taxa responsible for dissimilatory N metabolisms in the tannery wastewater treatment system undergoing bioaugmentation. This metagenomic insight into the nitrogen metabolism will contribute to a successful monitoring and operation of the eco-friendly tannery wastewater treatment system.</P>
A Study on the Oral Toxicity of Mecasin in Rats
Jeong, Hohyun,Lee, Jongchul,Cha, Eunhye,Park, Manyong,Son, Ilhong,Song, Bongkeun,Kim, Sungchul KOREAN PHARMACOPUNCTURE INSTITUTE 2014 Journal of pharmacopuncture Vol.17 No.4
Objectives: In this study, we investigated the oral toxicity of Gami-Jakyak Gamcho buja Decoction (Mecasin) to develop safe treatments. Methods: All experiments were conducted at the Medvill, an institution authorized to perform non-clinical studies, under the Good Laboratory Practice (GLP) regulations. In order to investigate the oral toxicity of Mecasin, we administered Mecasin orally to rats. Sprague-Dawley rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of Mecasin, 500 mg/kg, 1,000 mg/kg and 2,000 mg/kg, were administered to the experimental groups, and a dose of normal saline solution, 10 mL/kg, was administered to the control group. We examined the survival rate, weight, clinical signs, and gross findings. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results: No deaths or abnormalities occurred in any of the four groups. Although slight decreases in the weights of some female rats were noted on the third day, no significant changes in weights or gross findings between the control group and the experimental groups were observed. To check for abnormalities in organs, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs. Conclusion: The results showed that administration of 500 - 2,000 mg/kg of Mecasin did not cause any changes in weight or in the results of necropsy examinations. It also did not result in any mortalities. The above findings suggest that treatment with Mecasin is relatively safe. Further studies on this subject are needed to yield more concrete evidence.
Kim, In-Soo,Ekpeghere, Kaluibe,Ha, Shin-Young,Kim, Soo-Hyeon,Kim, Bong-Soo,Song, Bongkeun,Chun, Jongsik,Chang, Jae-Soo,Kim, Hong-Gi,Koh, Sung-Cheol Marcel Dekker 2013 Journal of environmental science and health. Part Vol.48 No.13
<P>A novel microbial consortium (BM-S-1) enriched from natural soils was successfully used to treat tannery wastewater from leather manufacturing industries in Korea on a pilot scale. The objective of this study was to determine whether augmentation with a novel microbial consortium BM-S-1could successfully treat the recalcitrant wastewater without chemical pre-treatment in a tannery wastewater treatment system. Chemical oxygen demand (COD), total nitrogen (TN) and total phosphorus (TP) were monitored for water quality. The microbial population dynamics were analyzed using pyrosequencing, and denitrifying bacteria were quantified using real-time PCR (RT-PCR). The removal efficiencies for COD, TN and TP were greater than 91%, 79%, and 90%, respectively. The dominant phyla in the buffering tank (B), primary aeration (PA), secondary aeration (SA) and sludge digestion tank (SD) were Proteobacteria, Firmicutes, Bacteroidetes, Planctomycetes and Deinococcus-Thermus. Cluster analysis based on the UniFrac distance of the species in the different stages showed that the PA is similar to the SA, whereas the B is similar to the SD. qPCR of the nosZ genes showed the highest abundance of denitrifiers in B, which was increased 734-fold compared to the influent (I). It was hypothesized that anaerobic denitrifiers and the diverse microbial community may play important roles in the biological treatment of tannery wastewater. This technology may also contribute to the full-scale treatment of industrial wastewater containing food processing wastewater and marine sediment with high organic content.</P>