Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma

Koo, Bon Seok,Lim, Hyun Sil,Lim, Young Chang,Yoon, Yeo-Hoon,Kim, Yong Min,Park, Yong Ho,Rha, Ki-Sang Springer - Society of Surgical Oncology 2010 Annals of surgical oncology Vol.17 No.4

Study on Factors Influencing the Productivity of Germ-line Chimeras from Embryonic Stem Cells

Sun-Uk Kim,Bon-Sil Koo,Sung-Lan Yu,Tae-Hoon Lee,Sangkyun Jung,Kyung-Kwang Lee,Dae-Yeul Yu 한국실험동물학회 2000 한국실험동물학회 학술발표대회 논문집 Vol.2000 No.-

장애물 없는 생활환경 인증기준을 적용한 도시공원 개선계획 - 보라매공원을 대상으로 -

서은실,구본학,Seo, Eun-Sil,Koo, Bon-Hak 한국조경학회 2015 韓國造景學會誌 Vol.43 No.5

고령화 및 다문화, 사회적약자의 외부활동이 증가됨에 따라 장애물 없는 생활환경의 구축이 요구되고 있어 공원에서도 이들의 편리한 이용을 위한 시설개선이 요구되고 있다. 이에 '장애물 없는 생활환경 인증제도'에 따른 기존공원의 BF인증 가능성을 분석하고, BF인증평가기준을 적용한 공원 계획을 수립하였다. 공원 오는 길 및 공원 내 주요 시설지를 연결하는 무장애 동선을 확보하고, 주요 시설이용에 불편함이 없도록 공원시설을 개선하며, 장애인 등의 이용이 편리하도록 안내체계를 개선하여 보라매공원을 무장애 공원으로 조성하고자 하였다. 본 연구는 기존 도시공원의 BF인증 가능성 여부를 진단해 보고, 누구나 이용하기 편리한 무장애공원 계획을 수립했다는데 의의가 있다. 연구를 진행하면서 BF인증제도의 한계점과 과제도 발견할 수 있었는데, 첫째는 BF인증제도에 대한 이해와 인식부족이다. 공원의 계획, 설계단계에서부터 장애물 없는 생활환경 조성을 위한 고려가 필요하나 설계 및 공사완료시점에 인증에 대한 검토를 함으로써 시간적, 경제적 손실이 큰 실정이다. 둘째는 공원의 BF인증 평가항목이 지형의 기복 및 기존 수목 등의 자연적 제약조건이 큰 외부공간의 특성이 반영되지 못한 세부평가항목을 적용하고 있다는 점이다. 셋째는 공원의 입지적 여건을 고려한 무장애 공원의 가이드라인 수립 및 공원의 BF인증 평가항목 등의 개선이 필요하다는 것이다. With the trend for the construction of barrier-free living environments in accordance with the ever-increasing external activity of the aging population, multi-culture families and socially disadvantaged, there is also a demand for the facilities improvement at parks for their convenience of use. This study analyzed the possibility of Barrier-Free Certification of an existing open space and defined its prototype renovation plan. This study is intended to help develop Borame Park into a barrier-free park by securing a barrier-free line of movement linking the major facilities sites within the park, improving park facilities lest there should be inconvenience in the use of the major facilities, and a guidance system convenient for use by physically and mentally impaired people. The significance of this study lies in the fact that it diagnosed the possibility of the BF Certification of existing urban parks and established a barrier-free park, which is easy for anyone to use. In the course of doing research on this, this study was able to discover the limitations of the BF Certification system, and its related tasks to be solved in the future as follows: The first thing this study shows is that there is a lack of understanding and awareness of the BF Certification system. Basically, there is a need for giving consideration to the development of a barrier-free living environment from the planning and design phase of a park, but in actuality, an examination of the certification is undertaken at the time of the completion of design and construction, which causes a large loss both time-wise and economically. Second, as evaluative items for the BF Certification of a park, applied are detailed evaluation items that fail to reflect the characteristics of an outdoor space whose natural constraints are large, such as geographical highs and lows and existing trees, plants, etc. Third, guidelines for establishment of a barrier-free park must be created in the light of the locational conditions of the park, followed by improvements of its BF Certification evaluation items.

$CoSi_{2}$ 에피박막을 확산원으로 이용하여 형성한 매우 얇은 접합의 전기적 특성

구본철,심현상,정연실,배규식,Koo, Bon-Cheol,Shim, Hyun-Sang,Jung, Yun-Sil,Bae, Kyoo-Sik 한국재료학회 1998 한국재료학회지 Vol.8 No.5

Co/Ti 이중막을 급속열처리하여 형성한 $CoSi_{2}$에 $As^+$을 이온주입한 후, 500~$1000^{\circ}C$에서 drive-in 열처리하여 매우얇은 $n_{+}$ p접합의 다이오드를 제작하고 I-V 특성을 측정하였다. $500^{\circ}C$에서 280초 drive-in 열처리하였을 때, 50nm정도의 매우 얇은접합이 형성되었고, 누설전류가 매우 낮아 가장 우수한 다이오드 특성을 나타내었다. 특히, Co 단일막을 사용한 다이오드에 비해 누설전류는 2order 이상 낮았으며, 이는 $CoSi_{2}$Si의 계면이 균일하였기 때문이다. $As^+$ was ion-implanted onto $CoSi_{2}$ thin films formed by rapidly thermal-annealed Co/Ti bilayers. Then the specimens were drive-in annealed at 500~100$0^{\circ}C$ to form ultra-shallow $n^+$p junction diodes and to measure their 1- V characteristics. When drive-in annealed at 50$0^{\circ}C$ for 280 sec., 50 nm thick ultra-shallow junctions were formed and di￢odes showed the best 1- V characteristics with low leakage current. In particular. the leakage current was 2 orders lower than that of diodes formed by using Co monolayer. It was attributed to uniform $CoSi_{2}$/Si interfaces.

Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

Jeong, Hyun-Woo,Jeon, Un Sil,Koo, Bon-Kyoung,Kim, Wan-Young,Im, Sun-Kyoung,Shin, Juhee,Cho, Yunje,Kim, Jin,Kong, Young-Yun American Society for Clinical Investigation 2009 The Journal of clinical investigation Vol.119 No.11

<P>The heterogeneous cellular composition of the mammalian renal collecting duct enables regulation of fluid, electrolytes, and acid-base homeostasis, but the molecular mechanism of its development has yet to be elucidated. The Notch signaling pathway is involved in cell fate determination and has been implicated in proximal-distal patterning in the mammalian kidney. To investigate the role of Notch signaling in renal collecting duct development, we generated mice in which Mind bomb-1 (Mib1), an E3 ubiquitin ligase required for the initiation of Notch signaling, was specifically inactivated in the ureteric bud of the developing kidney. Mice lacking Mib1 in the renal collecting duct displayed increased urinary production, decreased urinary osmolality, progressive hydronephrosis, sodium wasting, and a severe urinary concentrating defect manifested as nephrogenic diabetes insipidus. Histological analysis revealed a diminished number of principal cells and corresponding increase in the number of intercalated cells. Transgenic overexpression of Notch intracellular domain reversed the altered cellular composition of mutant renal collecting duct, with principal cells occupying the entire region. Our data demonstrate that Notch signaling is required for the development of the mammalian renal collecting duct and principal cell differentiation and indicate that pathway dysregulation may contribute to distal renal tubular disorders.</P>

UAM 항공기 지상장애물 탐지에 대한 연구

최인호(In-ho Choi),구본수(Bon-su Koo),김연실(Youn-sil Kim) 한국항공우주학회 2023 한국항공우주학회 학술발표회 논문집 Vol.2023 No.4

코발트 폴리사이드 게이트전극 형성에 관한 연구

심현상,구본철,정연실,배규식,Shim, Hyun-Sang,Koo, Bon-Cheol,Joung, Yeon-Sil,Bae, Kyoo-Sik 한국재료학회 1998 한국재료학회지 Vol.8 No.6

코발트 폴리사이드 게이트 전극을 형성할 때, 원주형(columnar)과 입자형(granular)다결정 Si 및 비정질 Si 기판위에 Co 단일막(Co monolayer)또는 Co/Ti 이중막(Co/Ti bilayer)을 사용하여 형성한 $CoSi_{2}$의 열정안정을 비교하여 기판의 결정성과 CoSi/ sub 2/ 형성방법이 열적안정성에 미치는 영향을 연구하였다.$ 900^{\circ}C$에서 600초까지 급속열처리하였을 때 , 기판을 비정질을 사용하거나 기판에 관계없이 Co/Ti 이중막을 사용하면 열적안정성이 향상되었다, 이는 평탄하고 깨끗한 기판 Si표면과 지연된 Co확산으로 인해,조성이 균일하고 계면이 평탄한 CoSi$_{2}$가 형성되었기 때문이다. $ CoSi_{2}$의 열적안정성에 가장 중요한 인자는 열처리 초기 처음 형성된 실리사이드의 조성 균일성과 기판과의 계면 평탄성이었다. For the formation of cobalt polycide gate electrode, CoSi, was grown on columnar poly-Si, granular poly-Si or amorphous Si by depositing either Co monolayer or Co/Ti bilayer and its thermal stability was compared to study effects of the substrate crystallinity and the silicide formation method. When specimens were rapidly heat-treated at 90$0^{\circ}C$ up to 600 seconds, using amorphous Si or Co/Ti on all substrates improved the thermal stability. This was attributed to the uniform chemical composition of initial CoSi, and its smooth interface with the substrates, induced by smooth and clean Si surface and delayed Co diffusion. The main factors determining the thermal stability were found to be composition uniformity and smooth interface of $CoSi_2$, intially formed at the early stage of the heat-treatment.

Spectrophotometric Determination of Soil Chemical Properties Using Soiltek^® KA-P Spectrophotometer

현해남,오상실,구본준,강호준,Hyun, Hae-Nam,Oh, Sang-Sil,Koo, Bon-Jun,Kang, Ho-Jun 한국토양비료학회 2000 한국토양비료학회지 Vol.33 No.2

일반 밭, 논, 과수원 및 비닐하우스 토양 78점을 채취하여 3반복으로 농촌진흥청 표준분석법과 Soiltek$^{(R)}$ KA-P 분광광도계법으로 유기물, 치환성 K, Ca 및 Mg, CEC, 유효규산 및 질산염 함량을 측정하였다. Soiltek$^{(R)}$ KA-P 분광광도계로 측정한 유기물, 치환성 Ca, 및 Mg 용액의 발색 안정도는 1시간 동안 약 2%정도 낮아졌으며, 치환성 K, CEC및 질산염은 거의 변화가 없었다. Soiltek$^{(R)}$ KA-P 분광광도계로 측정한 분석 절대값은 농촌진흥청 표준분석법으로 측정한 값과 거의 1:1의 관계를 갖고 있었으며, 결정계수($R^2$)는 0.9501 이상이었다. 두 방법으로 측정한 유기물, 치환성 K, Ca 및 Mg, CEC, 유효규산 및 질산염의 표준편차는 각각 ${\pm}1.8gkg^{-1}$, ${\pm}0.05cmol^+kg^{-1}$, ${\pm}0.18cmol^+kg^{-1}$ 및 ${\pm}0.13cmol^+kg^{-1}$, ${\pm}1.0cmol^+kg^{-1}$, ${\pm}5.0mgkg^{-1}$ 및 ${\pm}10.0mgkg^{-1}$ 이하였다. 모든 성분에 대한 분석값은 95% 신뢰수준을 만족시켰으며, 변이계수는 7~17% 이하였다. 따라서, 기기조작의 간편성 저가 기기의 사용, 정확도, 정밀도 등을 고려한다면 Soiltek$^{(R)}$ KA-P 분광광도계에서 제시하는 방법으로 측정하는 것도 유용한 방법이라고 생각된다. To enable rapid and convenient soil test, new soil analytical methods, which require only one instrument, UV/Vis spectrophotometer, were developed and named "Soiltek KA-P spectrophotometric methods". The Soiltek$^{(R)}$ KA-P spectrophotometric method was compared with standard method of RDA in analytical capability for soil chemical properties. Using the 78 soils collected from upland, paddy, orchard, and vinyl house soils, soil organic matter, exchangeable K, Ca, and Mg. CEC, available $SiO_2$, and nitrate were analyzed by the two methods. The color stability(ratio of the absorbance at elapsed time t to the absorbance at time t=0) of organic matter. Ca, Mg, and available $SiO_2$ decreased to about 2% within one hour. However, that of exchangeable K, CEC, and nitrate remained constant. The results obtained with Soiltek$^{(R)}$ KA-P spectrophotometric method showed highly significant correlation with those measured by the standard method of RDA($R^2$ >0.9501), in which the slopes were near unity of $1.0{\pm}0.05$. The standard deviation values of organic matter, exchangeable K, Ca, and Mg, CEC, available $SiO_2$, and nitrate were apparently lower than ${\pm}1.8gkg^{-1}$, ${\pm}0.05cmol^+kg^{-1}$, ${\pm}0.18cmol^+kg^{-1}$, and ${\pm}0.13cmol^+kg^{-1}$, ${\pm}1.0cmol^+kg^{-1}$, ${\pm}5.0mgkg^{-1}$, and ${\pm}10.0mgkg^{-1}$, respectively. All the measurements showed coefficients of variation of less than 7~17% and were within the confidence level of 95%, which means both the methods are precise. Considering the relative simplicity, low cost, precision and accuracy, the proposed Soiltek$^{(R)}$ KA-P spectrophotometric methods could be recommended as an alternative to standard method.