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Apoptosis-inducing Effect of Akebia Saponin D from the Roots of Dipsacus asper Wall in U937 Cells
정승일,Beng Zhou,배진범,김남석,김선근,권진,김대근,신태용,전훈,임종필,김홍준,김호경,오찬호 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Methanol extracts of the root of Dipsacus asper Wall (Dipsacaceae) were found to exhibit apoptosisinducing activities in U937 (human monocyte-like histiocytic) cells. Investigation of the active n-BuOH fraction led to the isolation of akebia saponin D (ASD). Structure was established by spectroscopic methods. Treatment of U937 cells with ASD induced apoptosis in a dose dependent manner. ASD exerted strong cytotoxicity against human and murine leukemia cells. It is significantly increased the subG1 cell population and expression of p53 and Bax gene. And also ASD enhanced NO production from RAW264.7 macrophage cells. Taken together, these results strongly indicate that ASD may exert apoptosis-inducing activity via induction of apoptosis through activation chiefly via the nitric oxide and apoptosis-related p53 and Bax gene expression. These data provide scientific evidence that Dipsacus asper Wall can be useful as a chemopreventive agent.
Apoptosis-inducing Effect of Akebia Saponin D from the Roots of Dipsacus asper Wall in U937 Cells
Jeong, Seung-Il,Zhou, Beng,Bae, Jin-Beom,Kim, Nam-Seok,Kim, Sun-Geun,Kwon, Jin,Kim, Dae-Keun,Shin, Tae-Yong,Jeon, Hoon,Lim, Jong-Phil,Kim, Hong-Jun,Kim, Ho-Kyoung,Oh, Chan-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
Methanol extracts of the root of Dipsacus asper Wall (Dipsacaceae) were found to exhibit apoptosis-inducing activities in U937 (human monocyte-like histiocytic) cells. Investigation of the active n-BuOH fraction led to the isolation of akebia saponin D (ASD). Structure was established by spectroscopic methods. Treatment of U937 cells with ASD induced apoptosis in a dose dependent manner. ASD exerted strong cytotoxicity against human and murine leukemia cells. It is significantly increased the subG1 cell population and expression of p53 and Bax gene. And also ASD enhanced NO production from RAW264.7 macrophage cells. Taken together, these results strongly indicate that ASD may exert apoptosis-inducing activity via induction of apoptosis through activation chiefly via the nitric oxide and apoptosis-related p53 and Bax gene expression. These data provide scientific evidence that Dipsacus asper Wall can be useful as a chemopreventive agent.
APMP.QM-K111-propane in nitrogen
Lin, Tsai-Yin,Liu, Hsin-Wang,Huang, Chiung-Kun,Kang, Namgoo,Bae, Hyun Kil,Woo, Jin Chun,Bi, Zhe,Zhou, Zeyi,Sinweeruthai, Ratirat,Wongjuk, Arnuttachai,Li, Hou,Keat, Teo Beng,Hui, Liu,Wu, Thomas,Ann, Ch BUREAU INTERNATIONAL DES POIDS ET MESURES 2018 METROLOGIA -BERLIN- Vol.55 No.1