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Bains, Sukhkarn,Reimert, Matthew,Win, Aung Zaw,Khan, Sana,Aparici, Carina Mari The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.2
We describe the case of a patient with known history of psoriasis that presented with 1 year of unexplained fever, muscle weakness and marked weight loss, suspicious for B symptoms of a malignant origin. [$^{18}F$]-Fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) scans demonstrated an unusual serpiginous pattern of uptake in the fascia and muscles as well as lymph node activity. Multiple histological samples, including a final PET-probe guided lymph node surgical resection, excluded malignancy and confirmed the diagnosis of reactive inflammatory changes, with a plausible diagnosis of autoimmune lymphoproliferative syndrome with associated lymphadenitis, fasciitis and myositis, possibly mediated by tumor necrosis factor (TNF) inhibitor. To our knowledge, there is no evidence of a previously reported FDG uptake pattern of fascia and muscle involvement in psoriatic arthritis.
Bain, Owen,Detela, Giulia,Kim, Hae-Won,Mason, Chris,Mathur, Anthony,Wall, Ivan B Future Medicine 2014 Regenerative medicine Vol.9 No.2
<P>It is very difficult to conserve critical cell characteristics during expansion in culture, particularly those of adult mesenchymal stromal cells (MSCs), whose characteristics can change rapidly even within a short period of expansion.</P>
Dhuna, Vikram,Bains, Jagmohan Singh,Kamboj, Sukhdev Singh,Singh, Jatinder,Shanmugavel,Saxena, Ajit Kumar Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.5
A lectin with in-vitro anticancer activity against established human cancer cell lines has been purified by affinity chromatography on asialofetuin-linked amino activated silica beads from the tubers of Arisaema tortuosum, popularly known as Himalayan Cobra lily, a monocot plant from the family Araceae. The bound Arisaema tortuosum lectin (ATL) was eluted with glycine-HCl buffer, pH 2.5. ATL was effectively inhibited by asialofetuin, a complex desialylated serum glycoprotein as well as by N-acetyl-D-lactosamine, a disaccharide. It gave a single band corresponding to a subunit molecular weight of 13.5 kDa in SDS-PAGE, pH 8.8 both under reducing and non reducing conditions. When subjected to gel-filtration on Biogel P-200, it was found to have a molecular weight of 54 kDa, suggesting a homotetramer structure, in which individual polypeptides are not bound to each other with disulfide bonds. ATL is a glycoprotein with 0.9% carbohydrate content, stable up to $55^{\circ}C$ and at pH 2 to 10. The lectin had no requirement for divalent metal ions i.e. $Ca^{2+}$ and $Mn^{2+}$ for its activity. However, as reported for other monocot lectins, ATL gave multiple bands in isoelectric focusing and Native PAGE, pH 8.3. The lectin was found to inhibit in vitro proliferation of human cancer cell lines HT29, SiHa and OVCAR-5.
Progress in agile engineering for the turbomachinery industry
Japikse, D.,Baines, N. C. 대한기계학회 1995 International Forum on Advances in Mechanical Engi Vol.1 No.1
The widespread use of computers has enabled the design procedures for rotating machines to become much more efficient. Developments in fluid dynamic and structural analyses, CFD, and the opportunities for self-diagnosing $quot;small machines$quot; are highlighted, together with the major accelerations in the design process which are possible. However, improvements depend on the correct utilization of the new technologies, appropriate design management, and the continuous education of designers.