Association of VAMP-2 and Syntaxin 1A Genes with Adult Attention Deficit Hyperactivity Disorder

Ay˚e Nur Inci Kenar,Özlem I˙zci Ay,Hasan Herken,Mehmet Emin Erdal 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.1

Objective The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolicdifferences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought toplay roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; itwas aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD. Methods One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were includedinto the study. DNA samples were extracted from whole blood and genetic analysis were performed. ResultsaaA significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphismaccording to the control group. These polymorphisms were found not to be associated with subtypes of ADHD. Conclusion It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.

Parathyromatosis: Critical Diagnosis Regarding Surgery and Pathologic Evaluation

Ayşegül Aksoy-Altinboga,Ayşegül Akder Sari,Türkan Rezanko,Mehmet Haciyanli,Aylin Orgen Calli 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.2

Parathyromatosis, in which several nodules of hyperfunctioning parathyroid tissue form in the neck and mediastinum, is a rare cause of recurrent hyperparathyroidism. However, there are some theories regarding the origin of parathyromatosis, and seeding after rupture of the parathyroid gland capsule during surgical removal of a parathyroid lesions is the most regarded one. Herein, we report a 41-year-old man who presented with multiple parathyroid nodules in and around the left thyroid lobe 5 years after parathyroid surgery for secondary hyperparathyroidism that was finally diagnosed as parathyromatosis. We discuss the differential diagnosis of parathyromatosis from other parathyroid tumors, particularly from parathyroid carcinoma, which is important in the management of a suspected lesion.

The effect of thermo-mechanical fatigue on the retentive force and dimensional changes in polyetheretherketone clasps with different thickness and undercut

Ayşegül Güleryüz,Cumhur Korkmaz,Ayşe Şener,Mehmet Ozan Taş 대한치과보철학회 2021 The Journal of Advanced Prosthodontics Vol.13 No.5

PURPOSE. Esthetic expectations have increased the use of polyetheretherketone (PEEK) clasps as alternatives to Cr-Co in removable partial dentures (RPDs). The objective of this study was to evaluate the retentive force and dimensional change of clasps with different thickness and undercut made from PEEK by the thermo-mechanical fatigue. MATERIALS AND METHODS. PEEK clasps (N = 48) with thicknesses of 1 or 1.50 mm and 48 premolar monolithic zirconia crowns with undercuts of 0.25 mm or 0.50 mm were fabricated. Samples are divided into four groups (C1-C4) and were subjected to 7200 thermal aging cycles (at 5 – 55°C). The changes in the retentive force and dimensions of the clasps were measured by micro-stress testing and micro-CT devices from five measurement points (M1 - M5). One-way ANOVA, paired t-test, two-way repeated ANOVA, and post-hoc tests were used to analyze the data (P < .05). RESULTS. The retentive forces of C1, C2, C3, and C4 groups in initial and final test were found to be 4.389-3.388 N, 4.67 - 3.396 N, 5.161 - 4.096 N, 5.459 - 4.141 N, respectively. The effects of retentive force of all PEEK clasps groups were significant decreased. Thermo-mechanical cycles caused significant dimensional changes at points with M2, M4, and M5, and abraded the clasp corners and increased the distance between the ends of the clasp, resulting in reduced retentive forces (P * = .016, P * = .042, P < .001, respectively). CONCLUSION. Thermo-mechanical aging decreases the retentive forces in PEEK clasps. Increasing the thickness and undercut amount of clasps decreases the amount of dimensional change. The values measured after aging are within the clinically acceptable limits.

Raw and pyrolyzed (with and without melamine) graphene nanoplatelets with different surface areas as PEM fuel cell catalyst supports

Öztürk Ayşenur,Bayrakçeken Yurtcan Ayşe 한국탄소학회 2021 Carbon Letters Vol.31 No.6

Platinum (Pt) catalysts dispersed on carbon-based support materials are generally used in the polymer electrolyte membrane (PEM) fuel cells. In this study, commercial graphene nanoplatelets (GNPs), with diferent surface areas (320, 530, 800 m2 g−1), were used as catalyst supports in PEM fuel cells. These GNPs were also pyrolyzed under the inert atmosphere, with and without melamine, as the nitrogen (N) source. Various characterizations (Elemental analysis, FTIR, Raman spectroscopy, BET, TEM, HRTEM, SAED, XRD, TGA, ICP-MS, contact angle measurement, CV, ORR, chronoamperometry, EIS, PEM fuel cell performance test) were performed for the detailed analysis of Pt/GNPs. Based on the three-electrode cell system, the lowest electrochemical surface area (ECSA) loss (29.9%), Pt mass activity loss (20.3%) and overall (charge and mass) resistance (42.2 Ω) were obtained with the Pt/M-530 catalyst. According to the in-situ PEM fuel cell performance results, the specifc peak power density was recorded as (450 mW mg Pt−1) for the Pt/R-530 catalyst, which has also the second most hydrophobic catalyst layer surface with the 146.5°±1.28° contact angle value. On the heels of Pt/R-530, the two best performances also belong to the Pt/M-530 (391 mW mg Pt−1) and Pt/P-530 (378 mW mg Pt−1) catalysts of the same group.

ON THE GEOMETRY OF RATIONAL BÉZIER CURVES

( Ayşe Yilmaz Ceylan ),( Tunahan Turhan ),( Gözde Özkan Tükel ) 호남수학회 2021 호남수학학술지 Vol.43 No.1

The purpose of this paper is to assign a movable frame to an arbitrary point of a rational Bézier curve on the 2-sphere S² in Euclidean 3-space R³ to provide a better understanding of the geometry of the curve. Especially, we obtain the formula of geodesic curvature for a quadratic rational Bézier curve that allows a curve to be characterized on the surface. Moreover, we give some important results and relations for the Darboux frame and geodesic curvature of a such curve. Then, in specific case, given characterizations for the quadratic rational Bézier curve are illustrated on a unit 2-sphere.

A Case Report of Pathergy-Like Reaction in a Patient with Behçet’s Disease Triggered by Wax Epilation

( Ayşe Boyvat ),( Merve Aygun ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.4

The effect of local application of thymoquinone, Nigella sativa’s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis

Ayşe Yılmaz Baştuğ,Ceyda Özçakır Tomruk,Elif Güzel,İlkay Özdemir,Gonca Duygu,Esma Kütan,Gül Merve Yalçın Ülker,Fatma Özen Arıcı 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.3

Purpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG–infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.

Te Efect of Repetitive Transcranial Magnetic Stimulation on Spasticity in Patients with Multiple Sclerosis

Ayça Uran Şan,Bilge Yılmaz,Serdar Kesikburun 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.4

Background and Purpose Tis randomized controlled study examined the efect of repetitive transcranial magnetic stimulation (rTMS) on spasticity in patients with multiple sclerosis (MS). Methods Tis study included 16 patients with a history of MS and spasticity in the adductor hip muscles according to the Modifed Ashworth Scale (MAS). Te participants were randomized into the active group (n=10) and control group (n=6), in which active rTMS and sham rTMS were applied in 10 sessions, respectively. A physical therapy and rehabilitation program was applied along with rTMS sessions in both groups. Te evaluation parameters were assessed at baseline and then 1 week and 1 month afer applying rTMS. Results Statistical analyses with post-hoc correction revealed statistically signifcant improvements in the active group compared to the control group in the bilateral MAS score, Penn Spasm Frequency Scale score, patient satisfaction, amount of urine leakage, actual health status, perceived health status, energy and fatigue, role limitations due to physical problems, social function, overall quality of life, cognitive functioning, physical health composite score, mental health composite score, and total score on the Multiple Sclerosis Quality of Life-54 (MSQOL-54) (p< 0.05). Statistically signifcant changes were detected in the MSQOL-54 social function and physical health composite scores of patients in the control group (p<0.05). Conclusions Active rTMS combined with a physical therapy program reduced spasticity in MS patients compared to the control group that received only physical therapy. Further comprehensive and more advanced studies are needed to confrm the present fndings.

Remarkable effects of deep eutectic solvents on the esterification of lactic acid with ethanol over Amberlyst-15

Ayşe Ezgi Ünlü,Azime Arıkaya,Aybike Altundağ,Serpil Takaç 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.1

Deep eutectic solvents (DESs) are widely used in numerous reactions both as a solvent and a catalyst. In this study, different types of DESs were investigated as a supplementary component for Amberlyst-15 to enhance its catalytic activity in the esterification reaction of lactic acid with ethanol. The effects of the following parameters such as DES type, choline chloride : glycerol (ChCl-Gly) (1 : 2) amount, molar ratio of reactants, temperature and agitation rate on the initial rate of reaction and yield of ethyl lactate were investigated. According to the results, DESs alone did not have any catalytic effect on the esterification; however, DESs together with Amberlyst-15 provided a significant increase in the initial rate of reaction and yield. The activation energy of the reaction decreased significantly with the combined use of Amberlyst-15 and ChCl-Gly (1 : 2). Internal and external mass transfer limitations were found to be negligible under optimum reaction conditions.

Corrosion Inhibition Behavior of Robinia pseudoacacia Leaves Extract as a Eco‑Friendly Inhibitor on Mild Steel in Acidic Media

Ayşe Ongun Yüce 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.4

The inhibition behaviour on mild steel (MS) of Robinia pseudoacacia leaves extract (RPLE) in different concentrations in0.5 M HCl as a green corrosion inhibitor was investigated by using electrochemical techniques, surface analysis. Electrochemicalımpedance spectroscopy (EIS) measurements demonstrated that RPLE augments the char transfer resistance andthen diminishes the double layer capacitance due to the creation of a deterrent layer on the MS with increasing concentration. Polarization measurements have shown that RPLE reducing both anodic and cathodic current density values is a mixed-typeinhibitor. Also in with and without RPLE environments, the inhibition efficiencies have decreased with increasing temperaturewhile the activation energy value increases with the addition of RPLE to acidic solution. Thermodynamic parameters (suchas ΔGoads and Kads) were obtained from electrochemical measurements. Adsorption of RPLE components on MS has beendescriptived of FT-IR (Fourier Transform İnfrared Spectroscopy) and SEM (Scanning Electron Microscopy) data confirmingthe entity of a obstacle film on MS.