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박한솔,( Daru Seto Bagus Anugrah ),안병현,임권택 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
A biodegradable, near-infrared (NIR) - responsive hydrogel is one of the most promising strategies as a remotely triggered drug carrier. A novel NIR-responsive hydrogels based on alginate structures were prepared for controllable drug release. The hydrogels were formed rapidly by reacting norbornene-functionalized alginates and tetrazine cross-linkers containing diselenide bonds via inverse electron demand Diels-Alder click chemistry. NIR sensitive indocyanine green (ICG) and a drug, doxorubicin (DOX) were incorporated in the hydrogel matrix during gelation. The hydrogels showed a suppressed release profile under physiological conditions, while NIR light triggered a rapid release of DOX. Under NIR-light irradiation, ICG generated reactive oxygen species which could decompose diselenide bonds in the hydrogel matrix, inducing the gel-sol transition and release of entrapped DOX.
Ramesh, Kalyan,Anugrah, Daru Seto Bagus,Lim, Kwon Taek Elsevier 2018 Reactive & functional polymers Vol.131 No.-
<P><B>Abstract</B></P> <P>In the present study, a pseudo-block copolymer was prepared from <I>β</I>-cyclodextrin terminated poly(<I>N</I>-acryloylmorpholine) (<I>β</I>-CD-PNAM) and adamantine-terminated linear poly(D,L-lactide) (AD-PDLLA), through host-guest interaction between <I>β</I>-CD and AD groups. Initially, the hydrophilic polymer PNAM was synthesized using reversible addition fragmentation polymerization, which was further linked to N<SUB>3</SUB>-<I>β</I>-CD through click reaction. In parallel, an AD terminated hydrophobic polymer, AD-PDLLA was synthesized using ring opening polymerization. The synthesized polymers were characterized by means of <SUP>1</SUP>H NMR, gel permeation chromatography and fourier transform infrared. Subsequently, the formation of a pseudo-block copolymer <I>via</I> inclusion complexation between the <I>β</I>-CD core and AD-moiety was confirmed by 2D-NOESY NMR and self-aggregation of the pseudo-block copolymer was investigated by fluorescence spectroscopy. In addition, doxorubicin (DOX) a hydrophobic drug was loaded into the supramolecular micelles and the release kinetics of DOX from the micelles was studied. The result revealed that DOX release was accelerated as the pH reduced from 7.4 to 6.4.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
최원태,임권택,( Daru Seto Bagus Anugrah ),( Sabrina Aufar Salma ),( Cuong M. Q. Le ) 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Chemical cross-linking of polymer incorporated multi-walled carbon nanotubes was prepared by azide-alkyne cycloaddition click chemistry. Firstly, block copolymer of poly(styrene-alt-maleic anhydride) (PSMA) were prepared by the reversible addition-fragmentation chain transfer (RAFT) polymerization. The highly reactive anhydride units were functionalized with furfuryl amine and propargyl amine in a one-pot reaction affording alkyne-furan bifunctional PSMA block copolymer (PSAF). The PSAF chains were covalently anchored to the surface of MWNTs affording PSAF/MWNTs by the Diels-Alder reaction in water under ultrasound assistance. Then, azide-alkyne cycloaddition click reaction took place between the PSAF/MWNTs and bis-(azidoethyl) disulfide as a crosslinking agent in the presence of Cu(0) wire/PMDETA. The obtained hybrid materials were characterized by TGA, FT-IR, Raman spectroscopy, and TEM analysis. The cross-linked PSAF/MWNTs could well enhance electrical conductivity.